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Immunology of homograft valves

  • Conference paper
Cardiac Valve Allografts

Abstract

The clinical use of cryopreserved homograft valves has become a well-accepted method for aortic valve replacement. Cryopreserved allografts have shown a superior long-term performance compared with grafts stored at 4°C (14). In contrast to these fresh-wet-stored valves, it seems that cryopreserved grafts keep their viability undamaged, allowing storage at − 196 °C for years of these rare and precious prostheses (12).

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References

  1. Barratt-Boyes RG, Roche MB, Subramanyan R, Pemperton JR, Whitlock RM (1987) Long-term follow-up patients with the antibiotic-sterilized aortic homograft valve inserted freehand in the aortic position. Circulation 75: 768–777

    Article  PubMed  CAS  Google Scholar 

  2. Daly RC, Orszulak TA, Schaff HV, McGovern E, Wallacee RB (1991) Long-term results of aortic valve replacement with non-viable homografts. Circulation 84(suppl 3): 81–88

    Google Scholar 

  3. Feindel CM, David TE, Bos J, Daly PA, Cardella CJ (1991) Recycled heart valves from transplant patients. J Heart Lung Transplant 10: 614–617

    PubMed  CAS  Google Scholar 

  4. Fieguth H-G, Haverich A, Schäfers H-J (1988) Cytoimmunologic monitoring in early and late cardiac rejection. J Heart Transplant 7: 95–101

    PubMed  CAS  Google Scholar 

  5. Fischlein T, Schütz A, Uhlig A, Frey R, Krupa W, Babic R, Thiery J, Reichart B (1994) Integrity and viability of homograft valves. Eur J Cardio-Thorac Surg 8: 425–430

    Article  CAS  Google Scholar 

  6. Fischlein T, Schütz A, Haushofer M, Frey R, Uhlig A, Detter Ch, Reichart B (1995) Immunologic reactions and viability of cryopreserved homografts. Ann Thorac Surg 60: 122–126

    Article  Google Scholar 

  7. Hammer C, Reichenspurner H, Ertel W, Reichart B, Überfuhr P, Kemkes BM, Gokel M (1984) Cytological and immunologieal monitoring of cyclosporine-treated human heart recipients. J Heart Transplant 3: 228–231

    Google Scholar 

  8. Hammer C (1989) Cytology intransplantation. Schulz Verlag, Percha, Starnberg, Germany, pp 127–154

    Google Scholar 

  9. Hopkins RA (1989) Rationale for use of cryopreserved allograft tissues for cardiac reconstruction. In: Hopkins RA (ed) Cardiac Reconstruction with Allograft Valves. Springer Verlag Berlin Heidelberg, pp 15–19

    Chapter  Google Scholar 

  10. Kupiee-Weglinski JW, Diamentstein T, Tilney NL (1988) Interleukin-2 receptor targeted therapy-rationale and applications in organ transplantation. Transplantation 46: 785–792

    Article  Google Scholar 

  11. May RM, Cooper DKR, Du Toit Ed, Reichart B (1990) Cytoimmunological monitoring after heart-lung transplantation. J Heart Transplant 9: 133–135

    PubMed  CAS  Google Scholar 

  12. O’Brien MF, Stafford EG, Gardur M (1987) The viable cryopreserved allograft aortic valve. J Cardiac Surg 2(suppl 1): 815–822

    Google Scholar 

  13. O’Brien MF, Stafford EG, Gardner AH, Pohner PG, McGrifin DC (1987) A comparison of aortic valve replacement with viable cryopreserved and fresh allograft valves, with a note on chromosomal studies. J Thorac Cardiovasc Surg 94: 812–823

    PubMed  Google Scholar 

  14. O’Brien MF, McGriffin DC, et al. (1991) Allograft aortic valve replacement: long-term comparative clinical analysis of the viable cryopreserved and antibiotic 4 °C stored valves. J Cardiac Surg 6(suppl): 534–543

    Google Scholar 

  15. Ross DN (1991) Technique of aortic valve replacement with a homograft: orthotopic replacement. Ann Thorac Surg 52: 154–156

    Article  PubMed  CAS  Google Scholar 

  16. Schütz A, Breuer M, Engelhardt B, Brandi U, Hammer C, Kemkes BM (1991) Comparison of acute rejection in sensitized (“domino”) and unsensitized donor hearts. Tex Heart Inst 14: 286–292

    Google Scholar 

  17. Schütz A, Pratschke J, Breuer M, Hammer C, Engelhardt M, Brandi U, Babic R, Reichart B, Kemkes BM (1992) Allogeneic heart transplantation following xenogeneic bridging. Transplant Int 5: 307–310

    Google Scholar 

  18. Schütz A, Kemkes BM, Breuer M, Brandi U, Engelhardt M, Kugler C, Manz C, Hatz RR, Gockel JM, Hammer C (1992) Kinetics and dynamics of acute rejection after heterotopic heart transplantation. J Heart Lung Transplant 11: 189–300

    Google Scholar 

  19. Schütz A, Fischlein T, Breuer M, Haushofer M, Uhlig A, Detter Ch, Kemkes BM, Hammer C, Reichart B (1994) Cytoimmunological monitoring after homograft valve replacement. Eur J Cardio-Thorac Surg 8: 609–612

    Article  Google Scholar 

  20. Von Willebrand E, Sandberg M, Salmela K, Isoniemi H, Häyry(1994) Expression of ICAM-1 and HLA class II in acute cellular and vascular rejection of human kidney allografts. Transpl Int 7: 1–3

    Article  Google Scholar 

  21. Yacoub HM, Suitters A, Khaghani A, Rose M (1986) Localization of major histocompatibility complex (HLA, ABC, DR) antigens in aortic homografts. In: Bodnar E, Yacoub HM (eds) Biological Bioprosthetic Valves. Yorke Medius Books, New York, pp 64–72

    Google Scholar 

  22. Yankah AC, Feller AC, Thiede A, Westphal E, Bernhard A (1986) Identification of surface antigens of endothelial cell of fresh preserved heart allografts. Thorac Cardiovasc Surg 34(suppl): 1–10

    Google Scholar 

  23. Yankah AC, Wottge H-U, Müller-Hermelink HK (1987) Transplantation of aortic and plumonary allografts, enhanced viability of endothelial cells by cryopreservation, importance of histocompatibility. J Cardiac Surg 2(suppl): 209–220

    CAS  Google Scholar 

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© 1997 Springer-Verlag Berlin Heidelberg

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Schütz, A. (1997). Immunology of homograft valves. In: Yacoub, M.H., Yankah, A.C., Hetzer, R. (eds) Cardiac Valve Allografts. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-59250-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-59250-8_9

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63915-9

  • Online ISBN: 978-3-642-59250-8

  • eBook Packages: Springer Book Archive

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