Zusammenfassung
Der Gastrointestinaltrakt ist das größte endokrine Organ des Körpers. Seine Hormone werden aus endokrinen Zellen in der Schleimhaut des Magens, des Dünn- und Dickdarms bzw. aus dem Pankreas durch nervale Aktivität, humorale Stimuli oder durch mechanische oder chemische Reize im Rahmen der Nahrungsaufnahme freigesetzt [12, 31]. Die gastrointestinalen Hormone sind auf bestimmte für das Hormon charakteristische Bereiche des Intestinums beschränkt (Abb. 10.1). Nur Somatostatin kommt ubiquitär im Gastrointestinaltrakt vor.
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Literatur
Baldwin GS (1995) The role of gastrin and cholecystokinin in normal and neoplastic gastrointestinal growth. J Gastroenterol Hepatol 10 (2): 215–232
Baldwin GS, Whitehead RH (1994) Gut hormones, growth and malignancy. [Review]. Baillieres Clin Endocrinol Metab 8 (1): 185–214
Bayliss WM, Starling EH (1902) The mechanism of pan-creatic secretion. J Physiol (London) 28: 325–353
Besson I, Ingrand P, Person B, Boutroux D, Heresbach D et al. (1995) Sclerotherapy with or without octreotide for acute variceal bleeding. N Engl J Med 333 (9): 555–560
Boirivant M, Fais S, Annibale B, Agostini D, Delle Fave G, Pallone F (1994) Vasoactive intestinal polypeptide modulates the in vitro immunoglobulin A production by intestinal lamina propria lymphocytes. Gastroenterology 106 (3): 576–582
Bold RJ, Ishizuka J, Townsend CM Jr, Thompson JC (1993) Biomolecular advances in gastrointestinal hormones. Arch Surg 128 (11): 1268–1273
Bordi C, D’Adda T, Azzoni C, Pilato FP, Caruana P (1995) Hypergastrinemia and gastric enterochromaffin-like cells. Am J Surg Pathol 19 (Suppl 1): 8–19
Bueno L, Fioramonti J (1994) Neurohormonal control of intestinal transit. Reprod Nutr Develop 34 (6): 513–525
Caron P, Cogne M, Gusthiot-Joudet B, Wakim S, Catus F, Bayard F (1995) Intramuscular injections of slow-release lanreotide (BIM 23014) in acromegalic patients previously treated with continuous subcutaneous infusion of octreotide (SMS 201–995). Eur J Endocrinol 132 (3): 320–325
Chow BK (1995) Molecular cloning and functional characterization of a human secretin receptor. Biochem Biophys Res Commun 212 (1): 204–211
Crawley JN, Corwin RL (1994) Biological actions of cholecystokinin. Peptides. 15 (4): 731–755
Dietrich JB (1994) Neuropeptides, antagonists and cell proliferation: bombesin as an example. Cell Mol Biol 40 (6): 731–746
Dimaline R, Dockray GJ (1994) Evolution of the gastrointestinal endocrine system (with special reference to gastrin and CCK). Baillieres Clin Endocrinol Metabol 8 (1): 1–24
Dockray GJ (1994) The G. W. Harris Prize Lecture. The gut endocrine system and its control. [Review]. Exp Physiol 79 (5): 607–634
Dumont Y, Martel JC, Fournier A, St-Pierre S, Quirion R (1992) Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Progr Neurobiol 38 (2): 125–167
Eberlein GA, Eysselein VE, Schaeffer M et al. (1989) A new molecular form of PYY: structural characterization of human PYY(3–36) and PYY(1–36). Peptides 10: 797–803
Elahi D, McAloon-Dyke M, Fukagawa NK, Meneilly GS, Sclater AL et al. (1994) The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7–37) in normal and diabetic subjects. Regul Pept 51 (1): 63–74
Evans TC, Crittenden SL, Kodoyianni V, Kimble J (1994) Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo. Cell 77: 183–194
Eysselein VE, Eberlein GA, Grandt D, Schaeffer M, Zehres B et al. (1990) Structural characterization of canine PYY. Peptides 11: 111–116
Fahrenkrug J (1993) Transmitter role of vasoactive intestinal peptide. Pharmacol Toxicol 72 (6): 354–363
Fehmann HC, Goke R, Goke B (1995) Cell and molecular 36. biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr Rev 16 (3): 390–410
Freston JW, Borch K, Brand SJ et al. (1995) Effects of 37. hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells. A review and analysis. Digest Dis Sci 40 (Suppl 2): 50S–62S
Garrett NE, Mapp PI, Cruwys SC, Kidd BL, Blake DR(1992) Role of substance P in inflammatory arthritis. Ann Rheum Dis 51 (8): 1014–1018
Glasbrenner B, Dominguez-Munoz E, Riepl RL, Vetsi A, Malfertheiner P (1995) Cholecystokinin and pancreatic 39. polypeptide release in diabetic patients with and without autonomic neuropathy. Dig Dis Sci 40 (2): 406–411
Grandt D, Burckhardt B, Schimiczek M et al. (1992) Human PYY 3–36 inhibits gastric acid secretoin (gas) in man. Regul Pept 40 (2): 158
Grandt D, Layer P, Rippel K et al. (1992) Peptide YY (PYY) inhibits endogenously stimulated pancreatic enzyme secretion in man. Regul Pept 40 (2): 160
Grandt D, Teyssen S, Schimiczek M, Reeve JRJ, Feth F et al. (1992) Novel generation of hormone receptor specifi-city by amino terminal processing of peptide YY. Biochem Biophys Res Commun 186: 1299–1306
Grandt D, Dahms P, Schimiczek M, Eysselein VE, Reeve JR Jr, Mentlein R (1993) Proteolytisches Processing durch Dipeptidyl-Aminopeptidase IV generiert Rezeptorselektivität für PYY (PYY). Med Klinik 88: 143–145
Guelrud M, Rossiter A, Souney PF, Rossiter G, Fanikos J, Mujica V (1992) The effect of vasoactive intestinal poly-peptide on the lower esophageal sphincter in achalasia. Gastroenterology 103 (2): 377–382
Gutniak M, Orskov C, Holst JJ, Ahren B, Efendic S (1992) Antidiabetogenic effect of glucagon-like peptide-1 (736)amide in normal subjects and patients with diabetes mellitus. N Engl J Med 326 (20): 1316–1322
Harding RK, McDonald TJ (1989) Identification and characterization of the emetic effects of peptide YY. Peptides 10: 21–24
Hazelwood RL (1993) The pancreatic polypeptide (PP-fold) family: gastrointestinal, vascular, and feeding behavioral implications. Proc Soc Exp Biol Med 202 (1): 44–63
Holst JJ (1994) Glucagonlike peptide 1: a newly discov-ered gastrointestinal hormone. Gastroenterology 107 (6): 1848–1855
Holst JJ, Schmidt P (1994) Gut hormones and intestinal function. Baillieres Clin Endocrinol Metab 8 (1): 137–164
Imperiale TF, Teran JC, McCullough AJ (1995) A meta-analysis of somatostatin versus vasopressin in the management of acute esophageal variceal hemorrhage. Gastroenterology 109 (4): 1289–1294
Jiang S, Ulrich C (1995) Molecular cloning and functional expression of a human pancreatic secretin receptor. Biochem Biophys Res Commun 207 (3): 883–890
Jin HO, Song CW, Chang TM, Chey WY (1994) Roles of gut hormones in negative-feedback regulation of pancre-atic exocrine secretion in humans. Gastroenterology 107 (6): 1828–1834
Jule Y (1993) Enkephalins and nervous system control of intestinal motility. [French]. Arch Int Physiol Biochimie Biophys 101 (4): A49–50
Krenning EP, Kwekkeboom DJ, de Jong M et al. (1994) Essentials of peptide receptor scintigraphy with emphasis on the somatostatin analog octreotide. Semin Oncol 21 5 (Suppl 13): 6–14
Krenning EP, Kwekkeboom DJ, Oei HY et al. (1994) Somatostatin receptor scintigraphy in carcinoids, gastrinomas and Cushing’s syndrome. Digestion 55 (Suppl 3): 54–59
Kubota M, Nakamura T, Motokura T, Mori S, Nishida A (1994) Erythromycin improves gastrointestinal motility in extremely low birthweight infants. Acta Paediatr Jap 36 (2): 198–201
Lamberts SW, Chayvialle JA, Krenning EP (1993) The visualization of gastroenteropancreatic endocrine tumors. Digestion 54 (Suppl 1): 92–97
Liddle RA (1995) Regulation of cholecystokinin secretion by intraluminal releasing factors. Am J Physiol 269 (3Pt1): G319–327
Liddle RA, Goldfine ID, Rosen MS, Taplitz RA, Williams JA (1985) Cholecystokinin bioactivity in human plasma: molecular forms, responses to feeding, and relationship to gallbladder contraction. J Clin Invest 75: 1144–1152
Lieverse RJ, Jansen JB, Masclee AA, Lamers CB (1994) Role of cholecystokinin in the regulation of satiation and satiety in humans. Ann N Y Acad Sci 713: 268–272
Lu Y, Owyang C (1995) Secretin at physiological doses inhibits gastric motility via a vagal afferent pathway. Am J Physiol 268 (6Pt1): G1012–6
McCready VR, Hickish TF (1994) Somatostatin imaging function [comment]. Lancet 343 (8898): 617
Modlin IM, Basson MD (1993) Clinical applications of gastrointestinal hormones. Endocrinol Metab Clin North Am 22 (4): 823–844
Mortazavi P, Mueller BA (1992) Erythromycin in gastrointestinal motility disturbances. Ann Pharmacother 26 (9): 1095–1097
Muff R, Born W, Fischer JA (1995) Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: homologous peptides, separate receptors and overlapping biological actions. Eur J Endocrinol 133 (1): 17–20
Nielsen FC, Rehfeld JF (1994) Measurement of gut hormone gene expression: mRNA and peptides. Baillieres Clin Endocrinol Metab 8 (1): 25–49
Otsuka M, Yoshioka K (1993) Neurotransmitter functions of mammalian tachykinins. Physiol Rev 73 (2): 229–308
Patel YC, Srikant CB (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1–5). Endocrinology 135 (6): 2814–2817
Patel DR, Kong Y, Sreedharan SP (1995) Molecular cloning and expression of a human secretin receptor. Mol Pharmacol 47 (3): 467–473
Pearson RK, Anderson B, Dixon JE (1993) Molecular biology of the peptide hormone families. Endocrinol Metab Clin North Am 22 (4): 753–774
Pedrazzini T, Brunner HR, Waeber B (1993) Neuropeptide Y and cardiovascular regulation. Curr Opinion Nephrol Hyperten 2 (1): 106–113
Peeters TL (1993) Erythromycin and other macrolides as prokinetic agents. Gastroenterology 105 (6): 1886–1899
Peeters TL, Muls E, Janssens J, Urbain JL, Bex M et al. (1992) Effect of motilin on gastric emptying in patients with diabetic gastroparesis. Gastroenterology 102 (1): 97–101
Pennathur A, Cioppi M, Fayad JB, Little AG (1993) Erythromycin, motilin, and the esophagus. Surgery 114 (2): 295–299
Pennathur A, Tran A, Cioppi M, Fayad J, Sieren GL, Little AG (1994) Erythromycin strengthens the defective lower esophageal sphincter in patients with gastroesophageal reflux disease. Am J Surg 167 (1): 169–173
Redfern JS, O’Dorisio TM (1993) Therapeutic uses of gastrointestinal peptides. Endocrinol Metab Clin North Am 22 (4): 845–873
Reeve JR Jr, Eysselein VE, Ho FJ, Chew P, Vigna SR et al. (1994) Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology. Ann N Y Acad Sci 713: 11–21
Schjoldager BT (1994) Role of CCK in gallbladder function. Ann N Y Acad Sci 713: 207–218
Sharkey KA (1992) Substance P and calcitonin gene-related peptide (CGRP) in gastrointestinal inflammation. Ann N Y Acad Sci 664: 425–442
Shulkes A (1994) Somatostatin: physiology and clinical applications. Baillieres Clin Endocrinol Metab 8 (1): 215–236
Simon DM, Cello JP, Valenzuela J, Levy R, Dickerson G et al. (1995) Multicenter trial of octreotide in patients with refractory acquired immunodeficiency syndrome-asso-ciated diarrhea. Gastroenterology 108 (6): 1753–1760
Spindel ER, Giladi E, Segerson TP, Nagalla S (1993) Bornbesin-like peptides: of ligands and receptors. Rec Prog Horm Res 48: 365–391
Stanfa L, Dickenson A, Xu XJ, Wiesenfeld-Hallin Z (1994) Cholecystokinin and morphine analgesia: variations on a theme. Trends Pharmacol Sci 15 (3): 65–66
Tack J (1995) Georges Brohee Prize 1994. Motilin and the enteric nervous system in the control of interdigestive and postprandial gastric motility. Acta Gastroenterologica Belgica. 58 (1): 21–30
Taylor SD, Soudah HC, Chey WY, Scheiman JM (1994) Duodenal acidification and secretin, but not intraduodenal fat, inhibit human gastric acid secretion via prostaglandins. Gastroenterology 107 (6): 1680–1685
Turton MD, O’Shea D, Gunn I, Beak SA, Edwards CMB et al. (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 (6560): 69–72
Virgolini I, Raderer M, Kurtaran A, Angelberger P, Banyai S et al. (1994) Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors. N Engl J Med 331 (17): 1116–1121
Waeber G, Thompson N, Waeber B, Brunner HR, Nicod P, Grouzmann E (1993) Neuropeptide Y expression and regulation in a differentiated rat insulin-secreting cell line. Endocrinology 133: 1061–1067
Waldum HL, Brenna E, Kleveland PM, Sandvik AK (1995) Gastrin-physiological and pathophysiological role: clinical consequences. Dig Dis 13 (1): 25–38
Walsh JH (1992) Physiology and pathophysiology of gastrin. Mount Sinai J Med 59 (2): 117–124
Weber FH Jr, Richards RD, McCallum RW (1993) Erythromycin: a motilin agonist and gastrointestinal pro-kinetic agent. Am J Gastroenterol 88 (4): 485–490
Wettstein JG, Bueno L, Junien JL (1994) CCK antagonists: pharmacology and therapeutic interest. Pharmacol Ther 62 (3): 267–282
Wettstein JG, Earley B, Junien JL (1995) Central nervous system pharmacology of neuropeptide Y. Pharmacol Ther 65 (3): 397–414
Williams JA, Blevins GT Jr (1993) Cholecystokinin and regulation of pancreatic acinar cell function. Physiol Rev 73 (4): 701–723
Willms B, Werner J, Holst JJ, Orskov C, Creutzfeldt W, Nauck MA (1996) Gastric emptying glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7–36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab 81 (1): 327–332
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Grandt, D., Eysselein, V., Goebell, H. (1997). Gastrointestinale Hormone. In: Stolecke, H. (eds) Endokrinologie des Kindes- und Jugendalters. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59043-6_10
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