Abstract
The identification of the amygdala as an essential neural substrate for fear conditioning has permitted neurophysiological examinations of synaptic processes in the amygdala that may mediate fear conditioning. We examined synaptic plasticity in the thalamoamygdala pathway known to mediate acoustic fear conditioning and the hippocampal-amygdala pathway, involved in contextual fear conditioning. Results indicate that theta burst high frequency stimulation can induce either LTP or LTD in both pathways. The mechanisms responsible for long-term changes (LTC) in the amygdala are to a great extent elusive and further work is planned to elucidate them.
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References
Aggleton J. P.: A description of intra-amygdaloid connections in the old world monkeys. Exp. Brain. Res. 57 390–399 (1985).
Amaral D.: Memory: Anatomical organization of the candidate brain regions. In F. Plum (Ed.) Handbook of physiology sec 1: Neurophysiology Vol 5: Higher functions of the brain (pp. 211–294). Bethesda MD: American Physiological Society (1987).
Andersen P. Bliss T.V.P. Skerde K. K.: Unit analysis of population spikes. Exp. Brain Res. 13, 208, 221 (1971).
Becahra A. et al.: Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 269, 1115–1118 (1995).
Bouton M. E. Bolles R. C.: Conditioned fear assessed by freezing and by the suppression of three different baselines. Anim Learn Behav 8, 429–434 (1980).
Campeau S. Davis M.: Lesions of the auditory thalamus block acquisition and expression of aversive conditioning to an auditory but not a visual stimulus measured with the fear potentiated startle paradigm. Soc. Neurosci. Abstr 17, 658 (1991).
Campeau S. Miserendino M. J. D. Davis M.: Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear potentiated startle to an auditory conditioned stimulus. Behay. Neurosci. 106, 569–574 (1992)
Chapman P. F. Bellavance L. L.: Induction of long-term potentiation in the baso-lateral amygdala does not depend on NMDA receptor activation. Synapse 11, 310–318 (1992).
Chapman P. F. et al.: Long-term synaptic potentiation in the amygdala. Synapse 6, 271–278 (1990).
Clugnet M. C. LeDoux J. E.: Synaptic plasticity in fear conditioning circuits: Induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body. J. Neurosci. 10, 2818–2824 (1990).
Davis M.: The role of the amygdala in conditioned fear. In J. P. Aggelton (Ed.) The amygdala: Neurobiological aspects of emotion memory and mental dysfunction (pp.255–305). New York: Wiley-Liss (1992)
Fanselow M. S. Kim J. J. Landeira-Fernandez J.:Anatomically selective blockade of Pavlovian fear conditioning by application of an NMDA antagonist to the amygdala and periqaueductal gray. Soc Neurosci Abstr 17, 659 (1991)
Farb C. F. LeDoux J. E. Milner T. A.: Glutamate is present in medial geniculate body neurons that project to lateral amygdala and in lateral amygdala presynaptic terminals. Soc. Neurosci. Abstr. 15, 890 (1989).
Gallagher, M, Holland P. C.: Understanding the function of the central nucleus: Is simple conditioning enough? In J. P. Aggelton (Ed.) The amygdala: neurobiological aspects of emotion memory and mental dysfunction (pp.307–322). New York: Wiley-Liss (1992).
Hitchcock J. M. Davis M.: Lesions of the amygdala but not of the cerebellum or red nucleus block conditioned fear as measured with the potentiated startle paradigm. Behay. Neurosci. 100, 11–22 (1986).
Iwata J. et al.: Intrinsic neurons in the amygdaloid field projected by the medial geniculate body mediate emotional responses conditioned to acoustic stimuli. Brain Res. 388, 195–214 (1986).
Izquierdo I. et al.: CNQX infused into rat hippocampus or amygdala disrupts the expression of memory of two different tasks. Behay. Neurol. Biol. 59, 1–4 (1993).
Kairiss E. W. et al.: Field potential evidence for LTP or feed forward inhibition in the rat dentate gyrus. Brain Res. 401 87–94 (1987).
Kapp B. S. et al.: Amygdala central nucleus lesions: Effects on heart rate conditioning in the rabbit. Physiol. Behay. 23, 1109–1117 (1979).
Kim J. J. et al.: N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression ofd fear conditioning. Beahv. Neurosci. 105, 126–133 (1991).
Kim J. J. et al.: Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear potentiated startle. Behay. Neurol. Biol. 59, 5–8 (1993).
Kim J. J. et al.: Selective impairment of long-term but not short-term conditional fear by the N-methyl-D-aspartate antagonist APV. Behay. Neurosci. 106, 591–596 (1992).
Kim J. J. Fanselow M. S.: Modality specific retrograde amnesia of fear. Science 256, 675–677 (1992).
LeDoux J. E. Sakaguchi A. Reis D. G.: Subcortical efferents projections of the medial geniculate nucleus mediate emotional responses conditioned to acoustic stimuli. J Neurosci 4, 683–698 (1984).
LeDoux J. E. et al.: The lateral amygdaloid nucleus: Sensory interface of the amygdala in fear conditioning. J Neurosci 10, 1062–1069 (1990).
Lomo T.: Patterns of activations in a monosynaptic cortical pathway: the perforant path input to the dentate area of the hippocampal formation. Exp. Brain Res. 12, 18–45 (1971).
Maren S. Fanselow M. S.: Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. J. Neurosci. 15, 7548–7564 (1995).
Maroun M. Yaniv D. Richter-Levin G.: Local circuit plasticity in the dentate gyrus following high-frequency stimulation. Isr. J. Medic. Sci., 32 sup., 41 (1996).
Miserendino M. J. D. et al.: Blocking of acquisition but not expression of conditioned fear potentiated startle by NMDA antagonists in the amygdala. Nature 319, 716–718 (1990)
Phillips R. G. LeDoux J. E.: Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behay. Neurosci. 106, 274–285 (1992a).
Phillips R. G. LeDoux J. E.: Overlapping and divergent projections of CA1 and the ventral subiculum to the amygdala. Soc. Neurosci. Abstr. 18, 518 (1992b).
Smith B. S. Millhouse O. E.: The connections between basolateral and central nuclei. Neuroscience letters 56, 307–309 (1985).
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Yaniv, D., Richter-Levin, G. (1998). Long-Term Changes (LTC) of Evoked Field Potentials in the Amygdala: A Model of Emotional Memory. In: Torre, V., Nicholls, J. (eds) Neural Circuits and Networks. NATO ASI Series, vol 167. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58955-3_7
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DOI: https://doi.org/10.1007/978-3-642-58955-3_7
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