Skip to main content
SpringerLink
Log in
Book cover

Pathologie des Thymus pp 261–293Cite as

Differentialdiagnostisch wichtige Mediastinaltumoren und tumorähnliche Läsionen

  • Chapter

  • 80 Accesses

Part of the book series: Springer Texts in Statistics ((STS))

Zusammenfassung

Aus Gründen der Tumortopographie (vorderes Mediastinum) spielen in der Differentialdiagnose primärer Thymustumoren neben malignen Lymphomen vor allem Keimzelltumoren (Teratome), Metastasen und tumorähnliche Läsionen eine Rolle (Tabelle 51). Die im Einzelfall problematische topographische Zuordnung maligner Lymphome zu thymogenen und/oder mediastinalen Lymphomen wurde bereits auf S. 230 diskutiert. Metastasen können sich aus praktisch allen Organregionen im Mediastinum entwickeln. Im folgenden soll lediglich auf die Keimzelltumoren/Teratome, auf die solitären fibrösen Pleuratumoren, auf die angiofollikuläre Lymphknotenhyperplasie und auf die fibrosierende Mediastinitis eingegangen werden.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  1. Aygun C, Slawson RG, Bajaj K, Salazar OM (1984) Primary mediastinal seminoma. Urology 23: 109–117

    CAS  PubMed  Google Scholar 

  2. Bailey D, Bauman R, Marks A (1988) Use of anti-seminoma monoclonal antibody to confirm the diagnosis of mediastinal seminoma. APMIS 96: 206–210

    CAS  PubMed  Google Scholar 

  3. Battifora H, Sheibani K, Tubbs RR, Kopinski MI, Sun TT (1984) Antikeratin antibodies in tumor diagnosis: distinction between seminoma and embryonal carcinoma. Cancer 54: 843–848

    CAS  PubMed  Google Scholar 

  4. Beckstead JH (1983) Alkaline phosphatase histochemistry in human germ cell neoplasms. Am J Surg Pathol 7: 341–349

    CAS  Google Scholar 

  5. Bergh NP, Gatzinsky P, Larsson S, Lundin P, Riddell B (1978) Tumors of the thymus and thymic region: III. Clinicopathological studies on teratomas and tumors of germ cell type. Ann Thorac Surg 25: 107–111

    CAS  PubMed  Google Scholar 

  6. Berry CL, Keeling J, Hilton C (1969) Teratoma in infancy and childhood: a review of 91 cases. J Pathol 98: 241–252

    CAS  PubMed  Google Scholar 

  7. Bordi C, DeVita O, Pollice L (1985) Full pancreatic endocrine differentiation in a mediastinal teratoma. Hum Pathol 16: 961–964

    CAS  PubMed  Google Scholar 

  8. Brown K, Collins JD, Batra P, Steckel RJ, Kagan AR (1989) Mediastinal germ cell tumor in a young woman. Med Pediatr Oncol 17:164–167

    CAS  PubMed  Google Scholar 

  9. Buerki H, Locher GW, Graepel P, Ruchti Ch, Brun del Reg, Hess MW (1977) Humoral antibodies against spermatopoietic cells associated with mediastinal germinoma. J Pathol 121: 183–186

    CAS  PubMed  Google Scholar 

  10. Burns BF, McCaughey WTE (1986) Unusual thymic seminomas. Arch Pathol Lab Med 110: 539–541

    CAS  PubMed  Google Scholar 

  11. Bush SE, Martinez A, Bagshaw MA (1981) Primary mediastinal seminoma. Cancer 48: 1877–1882

    CAS  PubMed  Google Scholar 

  12. Canty TG, Siemens R (1978) Malignant mediastinal teratoma in a 15-year-old girl. Cancer 41: 1623–1626

    CAS  PubMed  Google Scholar 

  13. Carney JA, Thompson DP, Johnson CL, Lynn HB (1972) Teratomas in children: clinical and pathologic aspects. J Pediatr Surg 7: 271–282

    CAS  PubMed  Google Scholar 

  14. Carter D, Bibro MC, Touloukian RJ (1982) Benign clinical behavior of immature mediastinal teratoma in infancy and childhood: Report of two cases and review of the literature. Cancer 49: 398–402

    CAS  PubMed  Google Scholar 

  15. Cox JD (1975) Primary malignant germinal tumors of the mediastinum: a study of 24 cases. Cancer 36: 1162–1168

    CAS  PubMed  Google Scholar 

  16. Daniel RA, Diveley WL, Edwards WH, Chamberlain N (1960) Mediastinal tumors. Ann Surg 151: 783–795

    PubMed  Google Scholar 

  17. Davis RD, Oldham HN, Sabiston CD (1987) Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management and results. Ann Thorac Surg 44: 229–237

    PubMed  Google Scholar 

  18. DeBlois GG (1995) Germ cell tumors. In: Kornstein MJ (1995) Pathology of the thymus and mediastinum. Saunders, Philadelphia London Toronto Montreal Sydney Tokyo, pp 172–190

    Google Scholar 

  19. DeMent SH (1990) Association between mediastinal germ cell tumors and hematologic malignancies: An update. Hum Pathol 21: 699–703

    CAS  PubMed  Google Scholar 

  20. DeMent SH, Eggleston JC, Spivak JL (1985) Association between mediastinal germ cell tumors and hematologic malignancies. Report of two cases and review of the literature. Am J Surg Pathol 9: 23–30

    CAS  PubMed  Google Scholar 

  21. Denk H, Moll R, Weybora W, Lackinger E, Venningerholz F, Beham A, Franke WW (1987) Intermediate filaments and desmosomal plaque proteins in testicular seminomas and nonseminomatous germ cell tumours as revealed by immuno-histochemistry. Virchows Arch A 410: 295–307

    CAS  Google Scholar 

  22. Dulmet EM, Macchiariani P, Suk B, Verley JM (1993) Germ cell tumors of the mediastinum: a thirty year experience, Cancer 72: 1894–1901

    CAS  PubMed  Google Scholar 

  23. Dunn PJS (1984) Pancreatic tissue in benign mediastinal teratoma. J Clin Pathol 37: 1105–1109

    CAS  PubMed  Google Scholar 

  24. Economou J, Trump D, Holmes E, Eggleston J (1982) Management of primary germ cell tumors of the mediastinum. J Thorac Cardiovasc Surg 83: 643–649

    CAS  PubMed  Google Scholar 

  25. Fox MA, Vix VA (1980) Endodermal sinus (yolk sac) tumors of the anterior mediastinum. AJR 135: 291–294

    CAS  PubMed  Google Scholar 

  26. Friedman NB (1951) The comparative morphogenesis of extragenital and gonadal teratoid tumors. Cancer 4: 265–276

    CAS  PubMed  Google Scholar 

  27. Friedman NB, Velde RL Van de (1981) Germ cell tumors in man, pleiotropic mice, and continuity of germplasm and somatoplasm. Hum Pathol 12: 772–776

    CAS  PubMed  Google Scholar 

  28. Gonzalez-Crussi F (1982) Extragonadal teratomas. In: Atlas of tumor pathology. 2nd Ser, Fasc 18. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  29. Gooneratne S, Keh P, Sreekanth S, Recant W, Talerman A (1985) Anterior mediastinal endodermal sinus (yolk sac) tumor in a female infant. Cancer 56: 1430–1433

    CAS  PubMed  Google Scholar 

  30. Hailemariam S, Engeler DS, Bannwart F, Amin MB (1997) Primary mediastinal germ cell tumor with intratubular germ cell neoplasia of the testis - further support for germ cell origin of these tumors. A case report. Cancer 79: 1031–1036

    CAS  PubMed  Google Scholar 

  31. Hodge J, Aponte G, McLaughlin E (1959) Primary mediastinal tumors. J Thorac Cardiovasc Surg 37: 730–744

    CAS  Google Scholar 

  32. Hofmann WJ, Otto HF (1992) Germ cell tumors and teratomas. Pathologic anatomy. In: Walter E, Willich E, Webb WR (eds) The thymus. Diagnostic imaging, functions, and pathologic anatomy. Springer, Berlin Heidelberg New York Tokyo, pp 180–182

    Google Scholar 

  33. Honicky RE, DePapp EW (1973) Mediastinal teratoma with endocrine function. Am J Dis Child 126: 650–653

    CAS  PubMed  Google Scholar 

  34. Hurt RD, Bruckman JE, Farrow GM, Bernatz PhE, Hahn RG, Earle JD (1982) Primary anterior mediastinal seminoma. Cancer 49: 1658–1663

    CAS  PubMed  Google Scholar 

  35. Irie T, Watanabe H, Kawaoi A, Takeuchi J (1982) Alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG), and carcinoembryonic antigen (CEA) demonstrated in the immature glands of mediastinal teratocarcinoma. A case report. Cancer 50: 1160–1165

    CAS  PubMed  Google Scholar 

  36. Jacobsen GK, Jacobsen M, Praetorius-Clausen P (1981) Distribution of tumor-associated antigens in the various histologic components of germ cell tumors of the testis. Am J Surg Pathol 5: 257–266

    CAS  PubMed  Google Scholar 

  37. Kay PH, Wells FC, Goldstraw P (1987) A multidisciplinary approach to primary nonseminomatous germ cell tumors of the mediastinum. Ann Thorac Surg 44: 578–582

    CAS  PubMed  Google Scholar 

  38. Kersh CR, Constable WC, Hahn SS, Spaulding CA, Eisert DR, Jenrette JM, Marks RD, Grayson J (1990) Primary malignant extragonadal germ cell tumors. An analysis of the effect of radiotherapy. Cancer 65: 2681–2685

    CAS  PubMed  Google Scholar 

  39. Kitzis M, Weiss AM, Michel F, Giul R, Nussaume O, Monteau M, Dournovo P, Thibault Ph (1981) Les seminomes thymiques. Nouv Presse Med 10: 337–340

    Google Scholar 

  40. Knapp RH, Fritz SR, Reiman HM (1982) Primary embryonal carcinoma and choriocarcinoma of the mediastinum. A case report. Arch Pathol Lab Med 106: 507–509

    CAS  PubMed  Google Scholar 

  41. Knapp RH, Hurt RD, Payne S, Farrow GM, Lewis BD, Hahn RG, Muhm JR, Earle JD (1985) Malignant germ cell tumors of the mediastinum. J Thorac Cardiovasc Surg 89: 82–89

    CAS  PubMed  Google Scholar 

  42. Kornstein MJ (1995) Pathology of the thymus and mediastinum. Saunders, Philadelphia London Toronto Montreal Sydney Tokyo

    Google Scholar 

  43. Kurman RJ, Scardino PT, McIntire KR, Waldmann TA, Javadpour N (1977) Cellular localization of alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of the testis using an indirect immunoperoxidase technique: a new approach to classification utilizing tumor markers. Cancer 40: 2136–2151

    CAS  PubMed  Google Scholar 

  44. Kuzur ME, Cobleigh MA, Greco A, Einhorn LH, Oldham RK (1982) Endodermal sinus tumor of the mediastinum. Cancer 50: 766–774

    CAS  PubMed  Google Scholar 

  45. Lachman MF, Kim K, Koo BC (1986) Mediastinal teratoma associated with Klinefelter’s syndrome. Arch Pathol Lab Med 110:1067–1971

    CAS  PubMed  Google Scholar 

  46. Lancaster KJ, Liang CY, Myers JC, McCabe KM (1997) Goblet cell carcinod arising in a mature teratoma of the mediastinum. Am J Surg Pathol 21: 109–113

    CAS  PubMed  Google Scholar 

  47. Lemarie E, Assouline PS, Diot P, Reynard J, Levasseur P, Droz J, Ruffle P (1992) Primary mediastinal germ cell tumors. Results of a French retrospective study. Chest 102: 1477–1483

    CAS  PubMed  Google Scholar 

  48. Levine GD (1973) Primary thymic seminoma - A neoplasm ultrastructurally similar to testicular seminoma and distinct from epithelial thymoma. Cancer 31: 729–741

    CAS  PubMed  Google Scholar 

  49. Lewis BD, Hurt RD, Payne WS, Farrow GM, Knapp RH, Muhm JR (1983) Benign teratomas of the mediastinum. J Thorac Cardiovasc Surg 86: 727–731

    CAS  PubMed  Google Scholar 

  50. Manivel C, Jessurun J, Wick MR, Dehner LP (1987) Placental alkaline phosphatase immunoreactivity in testicular germ-cell neoplasms. Am J Surg Pathol 11: 21–29

    CAS  PubMed  Google Scholar 

  51. Martini N, Golbey RB, Hajdu SI, Whitmore WF, Beattie EJ (1974) Primary mediastinal germ cell tumors. Cancer 33: 763–769

    CAS  PubMed  Google Scholar 

  52. McNeil MM, Leong ASY, Sage RE (1981) Primary mediastinal embryonal carcinoma in association with Klinefelter’s syndrome. Cancer 47: 343–345

    CAS  PubMed  Google Scholar 

  53. Moran CA, Suster S (1997a) Primary germ cell tumors of the mediastinum. I. Analysis of 322 cases with special emphasis on teratomatous lesions and a proposal for histopathologic classification and clinical staging. Cancer 80: 681–690

    CAS  Google Scholar 

  54. Moran CA, Suster S (1997b) Yolk sac tumors of the mediastinum with prominent spindle cell features: A clinicopathologic study of three cases. Am J Surg Pathol 21: 1173–1177

    CAS  Google Scholar 

  55. Moran CA, Suster S (1997c) Hepatoid yolk sac tumors of the mediastinum: A clinicopathologic and immunohistochemical study of four cases. Am J Surg Pathol 21: 1210–1214

    CAS  Google Scholar 

  56. Moran CA, Suster S (1997d) Primary mediastinal choriocarcinomas: A clinicopathologic and immunohistochemical study of eight cases. Am J Surg Pathol 21: 1007–1012

    CAS  Google Scholar 

  57. Moran CA, Suster S, Przygodzki RM, Koss MN (1997a) Primary germ cell tumors of the mediastinum. II. Mediastinal seminomas - A clinicopathologic and immuno-histochemical study of 120 cases. Cancer 80: 691–698

    CAS  Google Scholar 

  58. Moran CA, Suster S, Koss MN (1997b) Primary germ cell tumors of the mediastinum. III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum - A clinicopathologic and immunohistochemical study of 64 cases. Cancer 80: 699–707

    CAS  Google Scholar 

  59. Moriconi WJ, Taylor S, Huntrakoon M, MacArthur R, Bixler TJ (1985) Primary mediastinal germinomas in females: a case report and review of the literature. J Surg Oncol 29: 176–180

    CAS  PubMed  Google Scholar 

  60. Morinaga S, Nomori H, Kobayashi R, Atsumi Y (1994) Well-differentiated adenocarcinoma arising from mature cystic teratoma of the mediastinum (teratoma with malignant transformation). Report of a surgical case. Am J Clin Pathol 101: 531–534

    CAS  PubMed  Google Scholar 

  61. Mukai K, Adams WR (1979) Yolk sac tumor of the anterior mediastinum. Case report with light-and electronmicroscopic examination and immunohistochemical study of alpha-fetoprotein. Am J Surg Pathol 3: 77–83

    CAS  PubMed  Google Scholar 

  62. Mullen B, Richardson JD (1986) Primary anterior mediastinal tumors in children and adults. Ann Thorac Surg 42: 338–345

    CAS  PubMed  Google Scholar 

  63. Nichols CR (1991) Mediastinal germ cell tumors. Clinical features and biologic correlates. Chest 99: 79–119

    Google Scholar 

  64. Nichols CR (1992) Mediastinal germ cell tumors. Semin Thorac Cardiovasc Surg 4: 45–50

    CAS  PubMed  Google Scholar 

  65. Nichols CR, Hoffman R, Einhorn LH, Williams S, Wheeler L, Garnick M (1985) Hematologic malignancies associated with primary mediastinal germ-cell tumors. Ann Int Med 102: 603–609

    CAS  PubMed  Google Scholar 

  66. Nichols CR, Roth BJ, Heerema NA, Griep J, Tricot G (1990) Hematologic neoplasia associated with primary mediastinal germ-cell tumors. N Engl J Med 322: 1425–1429

    CAS  PubMed  Google Scholar 

  67. Niehans GA, Manivel C, Copland G, Scheithauer B, Wick M (1988) Immunohistochemistry of germ cell and trophoblastic neoplasms. Cancer 62: 1113–1123

    CAS  PubMed  Google Scholar 

  68. Norris HJ, Zirkin HJ, Benson WL (1976) Immature malignant teratoma of the ovary: a clinical and pathologic study of 58 cases. Cancer 37: 2359–2372

    CAS  PubMed  Google Scholar 

  69. Oberman HA, Libcke JH (1964) Malignant germinal neoplasms of the mediastinum. Cancer 17: 498–507

    CAS  PubMed  Google Scholar 

  70. Pachter MR, Lattes R (1964) „Germinal“ tumors of the mediastinum: A clinicopathologic study of adult teratomas, teratocarcinomas, choriocarcinomas and seminomas. Dis Chest 45: 301–310

    CAS  PubMed  Google Scholar 

  71. Polansky SM, Barwick KW, Ravin CE (1979) Primary mediastinal seminoma. Am J Roentgenol 132: 17–21

    CAS  Google Scholar 

  72. Przygodzki RM, Moran CA, Suster S, Khan MA, Swalsky PA, Bakker A, Koss MN, Finkelstein SD (1996) Primary mediastinal and testicular seminomas: A comparison of K-ras-2 gene sequence and p53 immunoperoxidase analysis of 26 cases. Hum Pathol 27: 975–979

    CAS  PubMed  Google Scholar 

  73. Raghavan D, Barrett A (1980) Mediastinal seminomas. Cancer 46: 1187–1191

    CAS  PubMed  Google Scholar 

  74. Recondo J, Libshitz HI (1978) Mediastinal extragonadal germ cell tumors. Urology 11: 369–375

    CAS  PubMed  Google Scholar 

  75. Reynolds TF, Yagoda A, Vurgin D, Golbey R (1979) Chemotherapy of mediastinal germ cell tumors. Semin Oncol 6: 113–115

    CAS  PubMed  Google Scholar 

  76. Ringertz N, Lidholm SO (1956) Mediastinal tumors and cysts. J Thorac Surg 31: 458–487

    CAS  PubMed  Google Scholar 

  77. Saabye J, Elbirk A, Andersen K (1987) Teratomas of the mediastinum. Scand J Thorac Cardiovasc Surg 21: 271–272

    CAS  PubMed  Google Scholar 

  78. Saegesser F, Zoupanos G, Jayet A, Gardiol D (1972) Tumeurs germinales malignes du mediastin. Ann Chir Thorac Cardiovasc 11: 71–82

    CAS  PubMed  Google Scholar 

  79. Sandhaus L, Strom RL, Mukai K (1981) Primary embryonal-choriocarcinoma of the mediastinum in a woman: a case report with immunohistochemical study. Am J Clin Pathol 75: 573–578

    CAS  PubMed  Google Scholar 

  80. Sass M, Jao W, Horn T, Keh PC (1983) Mediastinal yolk sac tumor: ultrastructural and immunofluorescent studies. Ultrastruc Pathol 4: 67–73

    CAS  Google Scholar 

  81. Schantz A, Sewall W, Castleman B (1972) Mediastinal germinoma. A study of 21 cases with an excellent prognosis. Cancer 30: 1189–1194

    Google Scholar 

  82. Schlumberger HG (1946) Teratoma of the anterior mediastinum in the group of military age. A study of sixteen cases, and review of the theories of genesis. Arch Pathol 41: 398–444

    CAS  Google Scholar 

  83. Schlumberger HG (1951) Tumors of the mediastinum. In: Atlas of tumor pathology, Fasc 18. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  84. Sickels EA, Belliveau RE, Wiernik PH (1974) Primary mediastinal choriocarcinoma in the male. Cancer 33: 1196–1203

    Google Scholar 

  85. Sloane JP, Ormerod MG (1981) Distribution of epithelial membrane antigen in normal and neoplastic tissues and its value in diagnostic tumor pathology. Cancer 47: 1786–1795

    CAS  PubMed  Google Scholar 

  86. Suda K, Mizuguchi K, Hebisawa A, Wakabayashi T, Saito S (1984) Pancreatic tissue in teratoma. Arch Pathol Lab Med 08: 835–837

    Google Scholar 

  87. Thomas WJ, Kelleher JF, Duval-Arnould B (1981) Successful treatment of metastatic extragonadal endodermal sinus (yolk sac) tumor in childhood. Cancer 48: 2371–2374

    CAS  PubMed  Google Scholar 

  88. Toner GC, Geller NL, Lin SY, Bosl GJ (1991) Extragonadal and poor risk nonseminomatous germ cell tumors. Cancer 67: 2049–2057

    CAS  PubMed  Google Scholar 

  89. Truong LD, Harris L, Mattioli C, Hawkins E, Lee A, Wheeler T, Lane M (1986) Endodermal sinus tumor of the mediastinum. A report of seven cases and review of the literature. Cancer 58: 730–739

    CAS  PubMed  Google Scholar 

  90. Ulbright TM, Loehrer PJ, Roth LM, Einhorn LH, Williams SD, Clark SA (1984) The development of non-germ cell malignancies within germ cell tumors: a clinico-pathologic study of 11 cases. Cancer 54:1824–1833

    CAS  PubMed  Google Scholar 

  91. Wenger ME, Dines DE, Ahmann DL, Good CA (1968) Primary mediastinal choriocarcinoma. Mayo Clin Proc 43: 570–575

    CAS  PubMed  Google Scholar 

  92. Wick MR, Rosai J (1990) Neuroendocrine, germ cell, and nonepithelial tumors. In: Givel J-C (ed) Surgery of the thymus. Pathology, associated disorders and surgical technique. Springer, Berlin Heidelberg New York Tokyo, pp 109–150

    Google Scholar 

  93. Wright CD, Kesler KA, Nichols CR, Mahomed Y, Einhorn LH, Miller ME, Brown JW (1990) Primary mediastinal nonseminomatous germ cell tumors: results of a multimodality approach. J Thorac Cardiovasc Surg 99: 210–217

    CAS  PubMed  Google Scholar 

  94. Wychulis AR, Payne WS, Clagett OTh, Woolner LB (1971) Surgical treatment of mediastinal tumors. A 40 year experience. J Thorac Cardiovasc Surg 62: 379–391

    CAS  PubMed  Google Scholar 

  95. Briselli MF, Mark EJ (1986) Solitary fibrous tumors of the pleura and benign extrapleural tumors of mesothelial origin. In: Antman K, Aisner J (eds) Asbestos-related malignancy. Grune & Stratton, Orlando, pp 165–178

    Google Scholar 

  96. Briselli MF, Mark EJ, Dickersin GR (1981) Solitary fibros tumors of the pleura: eight cases and review of 360 cases in the literature. Cancer 47: 2678–2689

    CAS  PubMed  Google Scholar 

  97. Brockmann M, Müller K-M (1991) Die pathologische Anatomie der primären und sekundären Pleuratumoren. In: Drings P, Vogt-Moykopf I (Hrsg) Thoraxtumoren. Diagnostik - Staging - gegenwärtiges Therapiekonzept, S 271–284. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  98. Bürrig K-F, Kastendieck H (1984) Ultrastructural observations on the histogenesis of localized fibrous tumours of the pleura (benign mesothelioma). Virochws Arch [Pathol Anat] 403: 413–424

    Google Scholar 

  99. Doglioni C, Dei Tos AP, Laurino L, Iuzzolino P, Chiarelli C, Celio MR, Viale G (1996) Calretinin. In: A novel immunocytochemical marker for mesothelioma. Am J Surg Pathol 20:1037–1046

    CAS  PubMed  Google Scholar 

  100. Doucet J, Dardick I, Srigley JR, van Nostrand AWP, Bell MA, Kahn HJ (1986) Localized fibrous tumour of serosal surfaces. Immunohistochemical and ultrastructural evidence for a type of mesothelioma. Virchows Arch [Pathol Anat] 409: 349–363

    CAS  Google Scholar 

  101. England DM, Lochholzer L, McCarthy MJ (1989) Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol 13: 640–658

    CAS  PubMed  Google Scholar 

  102. Flint A, Weiss SW (1995) CD-34 and keratin expression distinguishes solitary fibrous tumor (fibrous mesothelioma) of pleura from desmoplastic mesothelioma. Hum Pathol 26: 428–431

    CAS  PubMed  Google Scholar 

  103. Foster EA, Ackerman LV (1960) Localized mesotheliomas of the pleura. The pathologic evaluation of 18 cases. Am J Clin Pathol 34: 349–364

    CAS  PubMed  Google Scholar 

  104. Gotzos V, Vogt P, Celio MR (1996) The calcium binding protein Calretinin is a selective marker for malignant pleural mesotheliomas of the epithelial type. Path Res Pract 192: 137–147

    CAS  PubMed  Google Scholar 

  105. Hanau CA, Miettinen M (1995) Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 26: 440–449

    CAS  PubMed  Google Scholar 

  106. Hernandez FJ, Fernandez BB (1974) Localized fibrous tumors of pleura: a light and electron microscopic study. Cancer 34: 1667–1674

    CAS  PubMed  Google Scholar 

  107. Shimosato Y, Mukai K (1997) Tumors of the mediastinum. In: Atlas of tumor pathology, 3rd Ser, Fasc 21. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  108. Steinetz C, Clarke R, Jacobs GH, Abdul-Karim FW, Petrelli M, Tomashefski JF (1990) Localized fibrous tumors of the pleura: correlation of histopathological, immuno-histochemical and ultrastructural features. Pathol Res Pract 186: 344–357

    CAS  PubMed  Google Scholar 

  109. Witkin GB, Rosai J (1989) Solitary fibrous tumor of the mediastinum. A report of 14 cases. Am J Surg Pathol 13: 547–557

    CAS  PubMed  Google Scholar 

  110. Abell MA (1956) Mediastinal cysts. Arch Pathol 61: 360–379

    CAS  Google Scholar 

  111. Bernheim J, Griffel B, Versano S, Bruderman I (1980) Mediastinal leiomyosarcoma in the wall of a bronchial cyst [letter]. Arch Pathol Lab Med 104: 221

    CAS  PubMed  Google Scholar 

  112. Boyd DP, Midell AI (1968) Mediastinal cysts and tumors: an analysis of 96 cases. Surg Clin North Am 48: 493–505

    CAS  PubMed  Google Scholar 

  113. Chuang MT, Barba FA, Kaneko M, Teirstein AS (1981) Adenocarcinoma arising in an intrathoracic duplication cyst of foregut origin: a case report with review of the literature. Cancer 47: 1887–1890

    CAS  PubMed  Google Scholar 

  114. Cohen AJ, Thompson L, Edwards FH, Bellamy RF (1991) Primary cysts and tumors of the mediastinum. Ann Thorac Surg 51: 378–386

    CAS  PubMed  Google Scholar 

  115. Davis RD, Oldham HN, Sabiston DC (1987) Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management, and results. Ann Thorac Surg 44: 229–237

    PubMed  Google Scholar 

  116. Fallon M, Gordon ARG, Lendrum AC (1954) Mediastinal cysts of foregut origin associated with vertebral abnormalities. Brit J Surg 41: 520–533

    CAS  PubMed  Google Scholar 

  117. Marchevsky AM, Kaneko M (1992) Surgical pathology of the mediastinum, 2nd edn. Raven Press, New York

    Google Scholar 

  118. Olsen JB, Clemmensen O, Andersen K (1991) Adenocarcinoma arising in a foregut cyst of mediastinum. Ann Thorac Surg 51: 497–499

    CAS  PubMed  Google Scholar 

  119. Ovrum E, Birkeland S (1979) Mediastinal tumors and cysts. A review of 91 cases. Scand J Thorac Cardiovas Surg 13: 161–168

    CAS  Google Scholar 

  120. Ringertz N, Lidholm SO (1956) Mediastinal tumors and cysts. J Thorac Surg 31: 458–487

    CAS  PubMed  Google Scholar 

  121. Sirivella S, Ford WB, Zikria EA, Miller WH, Samadani SR, Sullivan ME (1985) Foregut cysts of the mediastinum: results in 20 consecutive surgically treated cases. J Thorac Cardiovasc Surg 90:776–782

    CAS  PubMed  Google Scholar 

  122. Uyama T, Monden Y, Sumitomo M (1989) CEA and CA 19–9 in benign pulmonary or mediastinal cystic lesions. J Surg Oncol 41: 103–108

    CAS  PubMed  Google Scholar 

  123. Whittaker LD, Lynn HB (1973) Mediastinal tumors and cysts in the pediatric patient. Surg Clin North Am 53: 893–904

    PubMed  Google Scholar 

  124. Abel H, Mall W, Zieger G, Krüger R, Vollmer I (1980) Das Castleman-Lymphom. Angiofollikuläre Lymphknotenhyperplasie als diagnostisches and therapeutisches Problem. Dtsch Med Wochenschr 105: 1536–1541

    CAS  PubMed  Google Scholar 

  125. Bartoli E, Massarelli G, Soggia G, Tanda F (1980) Multicentric giant lymph node hyperplasia. A hyperimmune syndrome with a rapidly progressive course. Am J Clin Pathol 73: 423–426

    CAS  PubMed  Google Scholar 

  126. Baruch Y, Ben Arie Y, Kerner H, Lorber M, Best LA, Gershoni Baruch R (1991) Giant lymph node hyperplasia (Castleman’s disease): a clinical study of eight patients. Postgrad Med J 67: 366–370

    CAS  PubMed  Google Scholar 

  127. Brandt SJ, Bodine DM, Dunbar CE, Nienhuis AW (1990) Dysregulated interleukin 6 expression produces a syndrome resembling Castelman’s disease in mice. J Clin Invest 86: 592–599

    CAS  PubMed Central  PubMed  Google Scholar 

  128. Castleman B (1954) Pathological discussion, case records of the Massachusetts General Hospital, Case 40011. N Engl J Med 250: 26–30

    Google Scholar 

  129. Castleman B (1955) Tumors of the thymus gland. In: Atlas of tumor pathology, Sec V, Fasc 19. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  130. Castleman B, Iverson L, Menendez VP (1956) Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer 9: 822–830

    CAS  PubMed  Google Scholar 

  131. Chan WC, Hargreaves H, Keller J (1984) Giant lymph node hyperplasia with unusual clinicopathologic features. Cancer 53: 2135–2139

    CAS  PubMed  Google Scholar 

  132. Chen KTK (1984) Castleman’s disease and Kaposi’s sarcoma. Am J Surg Pathol 8: 287–293

    CAS  PubMed  Google Scholar 

  133. Couch WD (1980) Giant lymph node hyperplasia with thrombotic thrombocytopenic purpura. Am J Clin Pathol 74: 340–344

    CAS  PubMed  Google Scholar 

  134. Crane AR, Carrigan PT (1953) Primary subpleural intrapulmonic thymoma. J Thorac Surg 25: 600–605

    CAS  PubMed  Google Scholar 

  135. Dickson D, Ben-Ezra JM, Reed J, Flax H, Janis R (1985) Multicentric giant lymph node hyperplasia, Kaposi’s sarcoma, and lymphoma. Arch Pathol Lab Med 109: 1013–1018

    CAS  PubMed  Google Scholar 

  136. Diebold J, Marche C, Audoin J, Aubert JP, Le Tourneau A, Bouton C, Reynes M, Wizniak J, Capron F, Tricottet V (1985) Lymph node modification in patients with the acquired immunodeficiency syndrome (AIDS) or with AIDS related complex (ARC). Pathol Res Pract 180: 590–611

    CAS  PubMed  Google Scholar 

  137. Emson HE (1973) Extrathoracic angiofollicular lymphoid hyperplasia with coincidental myasthenia gravis. Cancer 31: 241–245

    CAS  PubMed  Google Scholar 

  138. Fisher ER, Sieracki JC, Goldenberg DM (1970)Identity and nature of isolated lymphoid tumors (so-called nodal hyperplasia, hamartoma, and angiomatous hamartoma) as revealed by histologic, electron microscopic, and heterotransplantation studies. Cancer 25: 1286–1300

    CAS  PubMed  Google Scholar 

  139. Flendrig JA (1969) Het benigne reuzenlymfoom (the benign giant lymphoma). Proefschrift, Katholieke Universiteit to Nijmegen. N.V. Drukkerij Helmond, Helmond, The Netherlands

    Google Scholar 

  140. Forsee JH, Farnacci CJ, Balke HA (1953) Ectopia of primary thymic tumors. Ann Surg 138: 922–924

    CAS  PubMed  Google Scholar 

  141. Frizzera G (1985) Castleman’s disease: more questions than answers. Hum Pathol 16: 202–205

    CAS  PubMed  Google Scholar 

  142. Frizzera G (1988) Castleman’s disease and related disorders. Semin Diagn Pathol 5: 346–364

    CAS  PubMed  Google Scholar 

  143. Frizzera G (1992) Atypical lymphoproliferative disorders. In: Knowles DM (ed) Neoplastic hematopathology. Williams & Wilkins, Baltimore Hong Kong London Munich Philadelphia Sydney Tokyo, pp 459–495

    Google Scholar 

  144. Frizzera G, Massarelli G, Banks PM, Rosai J (1983)A systemic lymphoproliferative disorder with morphologic features of Castleman’s disease. Pathological findings in 15 patients. Am J Surg Pathol 7: 211–231

    CAS  PubMed  Google Scholar 

  145. Gaba A, Stein RS, Sweet DL, Variakojis D (1978) Multicentric giant lymph node hyperplasia. Am J Clin Pathol 69: 86–90

    CAS  PubMed  Google Scholar 

  146. Geary CG, Fox H (1978) Giant lymph node hyperplasia of the mediastinum and refractory anaemia. J Clin Pathol 31: 757–760

    CAS  PubMed  Google Scholar 

  147. Gerald W, Kostianovsky M, Rosai J (1990) Development of vascular neoplasia in Castleman’s disease. Report of seven cases. Am J Surg Pathol 14: 603–614

    CAS  PubMed  Google Scholar 

  148. Hall PA, Donaghy M, Cotter FE, Stansfield AG, Levinson DA (1989) An immunohistological and genotypic study of the plasma cell form of Castleman’s disease. Histopathology 14: 333–346

    CAS  PubMed  Google Scholar 

  149. Harris NL (1984) Hypervascular follicular hyperplasia and Kaposi’s sarcoma in patients at risk for AIDS [Letter] N Engl J Med 310: 462–463

    CAS  PubMed  Google Scholar 

  150. Harrison EG, Bernatz PhE (1963) Angiofollicular mediastinal lymph-node hyperplasia resembling thymoma. Arch Pathol 75: 284–292

    PubMed  Google Scholar 

  151. Hartmeier SH, Steurer J, Christen R, Fehr J, Schleiffenbaum B (1997) „Castleman’s Disease“ - seltene Ursache eines Status febrilis mit Lymphadenopathie. Dtsch Med Wochenschr 122: 1141–1146

    CAS  PubMed  Google Scholar 

  152. Jones EL, Crocker J, Gregory J, Guibarra M, Curran RC (1984) Angiofollicular lymph node hyperplasia (Castleman’s disease): An immunohistochemical and enzyme-histochemical study of the hyaline-vascular form of lesion. J Histopathol 144: 131–147

    CAS  Google Scholar 

  153. Karcher DS, Pearson CE, Butler WM, Hurwitz MA, Cassell PE (1981) Giant lymph node hyperplasia involving the thymus with associated nephrotic syndrome and myelofibrosis. Am J Clin Pathol 77: 100–104

    Google Scholar 

  154. Keller AR, Hochholzer L, Castleman B (1972) Hyaline-vascular and plasma-cell types of giant lymphnode hyperplasia of the mediastinum and other locations. Cancer 29: 670–683

    CAS  PubMed  Google Scholar 

  155. Kessler E (1985) Multicentric giant lymph node hyperplasia. A report of seven cases. Cancer 56.2446–2451

    CAS  PubMed  Google Scholar 

  156. Lachant NA, Sun NC, Leong LA, Oseas RS, Prince HE (1985) Multicentric angiofollicular lymph node hyperplasia (Castleman’s disease) followed by Kaposi’s sarcoma in two homosexual-males with acquired immunodeficiency syndrome (AIDS). Am J Clin Pathol 83: 27–33

    CAS  PubMed  Google Scholar 

  157. Lee SL, Rosner F, Rivero I, Feldman F, Hurwitz A (1965) Refractory anemia with abnormal iron metabolism. Its remission after resection of hyperplastic mediastinal lymphnodes. N Engl J Med 272: 761–766

    CAS  PubMed  Google Scholar 

  158. Leger Ravet MB, Peuchmaur M, Devergne O, Audouin J, Raphael M, Van Damme J, Galanaud P, Diebold J, Emilie D (1991) Interleukin-6 gene expression in Castleman’s disease. Blood 78: 2923–2930

    Google Scholar 

  159. Leibetseder F, Thurner J (1973) Angiofollikuläre Lmyphknotenhyperplasie (Zwiebelschalenlymphom). Med Klin 68: 817–820

    CAS  PubMed  Google Scholar 

  160. Lowenthal DA, Filippa DA, Richardson ME, Bertoni M, Straus DJ (1987) Generalized lymphadenopathy with morphologic features of Castleman’s disease in an HIV-positive man. Cancer 60: 2454–2458

    CAS  PubMed  Google Scholar 

  161. Marsh HJ, Colbourn DS, Donovan V, Staszewski H (1990) Systemic Castleman’s disease in association with Evan’s syndrome and vitiligo. Med Pediatr Oncol 18: 169–172

    CAS  PubMed  Google Scholar 

  162. Matsuda H, Mori M, Yasumoto K, Sugimachi K (1988) Angiofollicular lymph node hyperplasia arising from the intercostal space. Thorac 43: 337–338

    CAS  Google Scholar 

  163. Martin JME, Bell B, Ruether BA (1985) Giant lymph node hyperplasia (Castleman’s disease) of hyalin vascular type. Clinical heterogeneity with immunohistologic uniformity. Am J Clin Pathol 84: 439–446

    CAS  PubMed  Google Scholar 

  164. McCarty MJ, Vukelja SJ, Banks PM, Weiss RB (1995) Angiofollicular lymph node hyperplasia (Castleman’s disease). Cancer Treat Rev 21: 291–310

    CAS  PubMed  Google Scholar 

  165. Miller RT, Mukai K, Banks PM, Frizzera G (1984) Systemic lymphoproliferative disorder with morphologic features of Castleman’s disease. Immunoperoxidase study of cytoplasmic immunoglobulins. Arch Pathol Lab Med 108: 626–630

    CAS  PubMed  Google Scholar 

  166. Mito M, Takahashi M, Suda T, Yagisawa K, Shinada S, Moriyama Y, Shibata A (1991) Thrombocytosis and erythropoietin-unresponsive anemia in patients with Castleman’s disease. Am J Hematol 36: 77–78

    CAS  PubMed  Google Scholar 

  167. Ohyashiki JH, Ohyashiki K, Kawakubo K, Serizawa H, Abe K, Mikata A, Toyama K (1994) Molecular genetic, cytogenetic, and immunophenotypic analyses in Castleman’s disease of the plasma cell type. Am J Clin Pathol 101: 290–295

    CAS  PubMed  Google Scholar 

  168. Radaszkiewicz T, Hansmann M-L, Lennert K (1989) Monoclonality and polyclonality of plasma cells in Castleman’s disease of the plasma cell variant. Histopathology 14: 11–24

    CAS  PubMed  Google Scholar 

  169. Rosai J, Levine GD (1976) Tumors of the thymus. In: Atlas of tumor pathology, 2nd Ser, Fasc 13. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  170. Salisbury JR (1990) Castleman’s disease in childhood and adolescence: report of a case and review of literature. Pediatr Pathol 1o: 609–615

    Google Scholar 

  171. Samuels TH, Hamilton PA, Ngan B (1990) Mediastinal Castleman’s disease: demonstration with computed tomography and angiography. Can Assoc Radiol J 41: 380–383

    CAS  PubMed  Google Scholar 

  172. Steinberg JJ, Huang PL, Ljubich P, Lee Huang S (1990) Anti-erythropoietin antibodies in hyper-viscosity syndrome associated with giant lymph node hyperplasia (GLNH: Castleman’s disease). Br J Hematol 74: 543–544

    CAS  Google Scholar 

  173. Tanda F, Massarelli G, Costanzi G (1983) Multicentric giant lymph node hyperplasia: An immunohistochemical study. Hum Pathol 14: 1053–1058

    CAS  PubMed  Google Scholar 

  174. Van den Oord JJ, De Wolf-Peeters C, Tricot G, Desmet VJ (1984) Distribution of lymphocyte subsets in a case of angiofollicular lymphnode hyperplasia. Am J Clin Pathol 82: 491–495

    PubMed  Google Scholar 

  175. Virmani R, Bewtra C, McAllister HA, Schulte RD (1982) Intrapericardial giant lymph node hyperplasia. Am J Surg Pathol 6: 475–481

    CAS  PubMed  Google Scholar 

  176. Weisenburger DD, DeGowin RL, Gibson DPh, Armitage JO (1979) Remission of giant lymph node hyperplasia with anemia after radiotherapy. Cancer 44: 457–462

    CAS  PubMed  Google Scholar 

  177. Weisenburger DD, Nathwani BN, Winberg CD, Rappaport H (1985) Multicentric angiofollicular lymph node hyperplasia: A clinicopathologic study of 16 cases. Hum Pathol 16: 162–172

    CAS  PubMed  Google Scholar 

  178. Yabuhara A, Yanagiwawa M, Murata T, Kawai H, Komiyama A, Akjabane T, Itoh M, Ishii E, Fujimoto J, Hata J-I (1989) Giant lymph node hyperplasia (Castleman’s disease) with spontaneous production of high levels of B-cell differentiation factor activity. Cancer 63: 260–265

    CAS  PubMed  Google Scholar 

  179. Yoshizaki K, Matsuda T, Nishimoto N, Kuritani T, Taeho L, Aozasa K, Nakahata T, Kawai H, Tagoh H, Komori T, Kishimoto S, Hirano T, Kishimoto H (1989) Pathogenetic significance of interleukin-6 (IL-6/BSF-2) in Castleman’s disease. Blood 74: 1360–1367

    CAS  PubMed  Google Scholar 

  180. Zettergren L (1961) Probably neoplastic proliferation of lymphoid tissue (follicular lymphoreticuloma). Acta Pathol Microbiol Scand 51: 113–126

    CAS  PubMed  Google Scholar 

  181. Arnett EN, Bacos JM, Macher AM, Marsh HB, Savage DD, Fulmer JD, Roberts WC (1977) Fibrosing mediastinitis causing pulmonary arterialhypertension without pulmonary venous hypertension. Clinical and necropsy observations. Am J Med 63: 634–643

    CAS  PubMed  Google Scholar 

  182. Baum GL, Green RA, Schwarz J (1960) Enlarging pulmonary histoplasmoma. Am Rev Respir Dis 82: 771–726

    Google Scholar 

  183. Berry DF, Buccigrossi D, Peabody J, Peterson KL, Moser KM (1989) Pulmonary vascular occlusion and fibrosing mediastinitis. Chest 89: 296–301

    Google Scholar 

  184. British Medical Journal - Leading article (1971) Mediastinal and hilar fibrosis. Br Med J 6: 639–640

    Google Scholar 

  185. Carlin BW, Moser KM (1987) Pulmonary artery obstruction due to malignant fibrous histocytoma. Chest 92: 173–175

    CAS  PubMed  Google Scholar 

  186. Dent RG, Godden DJ, Stovin PGI, Stark JE (1983) Pulmonary hyalinising granuloma in association with retroperitoneal fibrosis. Thorax 38: 955–956

    CAS  PubMed  Google Scholar 

  187. Dines DE, Payne WS, Bernatz PE, Pairolero PC (1979) Mediastinal granuloma and fibrosing mediastinitis. Chest 75: 320–324

    CAS  PubMed  Google Scholar 

  188. Dozois RR, Bernatz PE, Woolner LB, Andersen HA (1968) Sclerosing mediastinitis involving major bronchi. Mayo Clin Proc 43: 557–569

    CAS  PubMed  Google Scholar 

  189. Fenner MN, Moran JP, Dillon JC, Madura JA (1987) Retroperitoneal fibrosis and sclerosing mediastinitis. Inn Med 80: 334–338

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pathologisches Institut der Universität, 69120, Heidelberg, Im Neuenheimer Feld 220-221, Deutschland

    Professor Dr.Dr.h.c. Herwart F. Otto

Authors
  1. Professor Dr.Dr.h.c. Herwart F. Otto
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Otto, H.F. (1998). Differentialdiagnostisch wichtige Mediastinaltumoren und tumorähnliche Läsionen. In: Pathologie des Thymus. Springer Texts in Statistics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58922-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58922-5_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63791-9

  • Online ISBN: 978-3-642-58922-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation