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Pharmacological Inhibition of Dopaminergic and Other Neurotransmitter Receptors Using Antisense Oligodeoxynucleotides

  • G. Davidkova
  • B. Weiss
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 131)

Abstract

In recent years a great number of studies have been carried out that apply antisense oligonucleotide technology to investigate neurobiological systems (for recent reviews, see Weiss et al. 1996, 1997a,b; Zon 1995). The antisense approach has been particularly useful in characterizing the pharmacological properties and biological functions of receptors for neurotransmitters. This is due to the rapid discovery of the molecular structure of new subtypes of neurotransmitter receptors, the pharmacological and biological properties of which remain largely unknown. Antisense compounds, by hybridizing specifically to the nucleic acids encoding the different receptor subtypes, have provided a highly selective means to reduce the expression, and thereby the levels, of individual receptors, an effect that is not attainable with traditional pharmacological antagonists. In addition to providing a highly selective means to study various neurobiological events, antisense compounds have the potential to be used as therapeutic agents in the management of neuropsychiatric and neurodegenerative disorders. An antisense strategy to reduce the function of neuroreceptors might have a further distinct advantage over traditional pharmacological antagonists in that antisense agents, unlike the conventional pharmacological antagonists, might not induce the upregulation of the very receptors they are intended to inhibit (Burt et al. 1977; Hyttel 1986; Rogue et al. 1991).

Keywords

Dopamine Receptor Neurotransmitter Receptor Antisense Oligodeoxynucleotides Dopamine Receptor Subtype Challenge Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1998

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  • G. Davidkova
  • B. Weiss

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