Triple Helix Strategies and Progress

  • T. Akiyama
  • M. Hogan
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 131)


The binding of single-stranded nucleic acids to a DNA duplex is a phenomenon which has been known for at least 40 years. Recently, it has been recognized that the formation of such triple helices could serve as the basis for the design of site specific duplex DNA binding agents. During the past 7 years, several laboratories have worked to understand the physical chemistry of triple helix formation, for the purposes of exploiting and enhancing this mode of biomolecular recognition. Some of the most advanced approaches to nucleic acid chemistry, drug delivery formulation, and structure-based molecular design have been applied to this effort. Here, we review those design efforts and discuss current progress in the application of triple helix forming oligonucleotides (TFOs) as the basis for duplex DNA specific drug design.


Triple Helix Nuclear Magnetic Resonance Study Triple Helix Structure Base Triplet Triplex Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1998

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  • T. Akiyama
  • M. Hogan

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