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Properties of ISIS 2302, an Inhibitor of Intercellular Adhesion Molecule-1, in Humans

  • W. R. ShanahanJr.
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 131)

Abstract

ISIS 2302 is a 20-base phosphorothioate oligodeoxynucleotide designed to specifically hybridize to a sequence in the 3′-untranslated region of the human intercellular adhesion molecule (ICAM)-1 message. ICAM-1, a member of the immunoglobulin superfamily, is an inducible transmembrane glycoprotein constitutively expressed at low levels on vascular endothelial cells and on a subset of leukocytes (Dustin et al. 1986;Rothlein et al. 1986;Simmons et al. 1988). In response to proinflammatory mediators, many cell types upregulate expression of ICAM-1 on their surface. The primary counterligands for ICAM-1 are the β2-integrins lymphocytic function-associated antigen (LFA)-1 and macrophage differentiation antigen (Mac)-1, expressed on leukocytes (Marlin and Springer 1987;Diamond et al. 1990).

Keywords

Phosphorothioate Oligonucleotide Intact Drug Acute Renal Allograft Rejection Isis Pharmaceutical Alternative Pathway Complement Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • W. R. ShanahanJr.

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