Basic Principles of Antisense Therapeutics

  • S. T. Crooke
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 131)


During the past few years, interest in developing antisense technology and in exploiting it for therapeutic purposes has been intense. Although progress has been gratifyingly rapid, the technology remains in its infancy and the questions that remain to be answered still outnumber the questions for which there are answers. Appropriately, considerable debate continues about the breadth of the utility of the approach and about the type of data required to “prove that a drug works through an antisense mechanism.”


Antisense Oligonucleotide Human Immune Deficiency Virus Antisense Oligodeoxynucleotide Phosphorothioate Oligonucleotide Antisense Drug 
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© Springer-Verlag Berlin Heidelberg 1998

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  • S. T. Crooke

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