Effect of EndothelinA Receptor Antagonist on Neuronal Injury in Global and Focal Ischemia

  • Y. Ohara
  • D. Dawson
  • H. Sugano
  • C. Ruetzler
  • N. Azzam
  • J. M. Hallenbeck
  • R. M. McCarron
  • M. Spatz
Conference paper


The involvement of endogenous endothelin-1 (ET-1) was evaluated in transient global brain ischemia (8 min) with reperfusion (72 h) and in focal permanent ischemia (4 h) of spontaneously hypertensive rats (SHR). In gerbils, postischemic treatment with an ETA receptor antagonist, Ro 61–1790, reversed the ischemia-induced hypoperfusion and preserved 64–74% of hippocampal CA1 neurons, compared with controls (20–44%). The pretreatment of SHR with Ro 61–1790 significantly increased cerebral microvascular perfusion, which was associated with a significant decrease (27%) in the volume of the ischemic lesion. These findings support the hypothesis that endogenously released ET-1 is an important mediator of ischemic injury.


Cerebral Blood Flow Middle Cerebral Artery Occlusion Focal Ischemia Cereb Blood Flow Microvascular Perfusion 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Y. Ohara
  • D. Dawson
  • H. Sugano
  • C. Ruetzler
  • N. Azzam
  • J. M. Hallenbeck
  • R. M. McCarron
  • M. Spatz

There are no affiliations available

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