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Retinoids in Neural Development

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Book cover Retinoids

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 139))

Abstract

The evidence for a crucial role for vitamin A and its derivatives, the retinoids, in the development and maintenance of the nervous system is now beyond doubt, and this chapter presents the data to support this contention. The evidence comes from several types of experiment: the induction of neural differentiation in embryonal carcinoma cells; the effects of excess retinoids; the effects of a deficiency of retinoids; the distribution of retinoid-binding proteins and retinoid receptors and the results of interference with their signalling functions; the detection of endogenous retinoids; and the distribution of retinoid synthesising enzymes. Each of these topics are reviewed below.

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  1. Department of Food Toxicology Center of Food Science, School of Veterinary Medicine, Bischofholer Damm, D-30173, Hannover, Germany

    Heinz Nau

  2. Department of Medicine Division of Preventive Medicine & Nutrition, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, NY, 10032, USA

    William S. Blaner Ph.D.

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Maden, M. (1999). Retinoids in Neural Development. In: Nau, H., Blaner, W.S. (eds) Retinoids. Handbook of Experimental Pharmacology, vol 139. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58483-1_14

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