Skip to main content
SpringerLink
Log in

The Concept of Organizing Pneumonia

  • Chapter
Tissue Repair and Fibrosis

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 93))

Abstract

At the beginning of the 19th century, Laennec described the sequential gross pathological stages of acute lobar pneumonia, which was later related to pneumococcal infection [27]. The first stage is congestion, in which the involved lobe is heavy and congested. During the next stage, called red hepatization, the lobe becomes red and dense, much like the liver. After a stage of gray and airless lung (grey hepatization), resolution of pneumonia usually occurs with eventual complete healing.

Supported by grant HCL-PHRC 93–97.005.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aruffo A (1996) CD44: one ligand, two functions. J Clin Invest 98:2191–2192

    Article  PubMed  CAS  Google Scholar 

  2. Aubert JD, Pare PD, Hogg JC, Hayashi S (1997) Platelet-derived growth factor in bronchiolitis obliterans-organizing pneumonia. Am J Respir Crit Care Med 155:676–681

    PubMed  CAS  Google Scholar 

  3. Barazzone C, Belin D, Piguet PF, Vassalli JD, Sappino AP (1996) Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury. J Clin Invest 98:2666–2673

    Article  PubMed  CAS  Google Scholar 

  4. Basset F, Ferrans VJ, Soler P, Takemura T, Fukuda Y, Crystal RG (1986) Intraluminal fibrosis in interstitial lung disorders. Am J Pathol 122:443–461

    PubMed  CAS  Google Scholar 

  5. Bellum SC, Dove D, Harley RA, Greene WB, Judson MA, London L, London SD (1997) Respiratory reovirus 1/L induction of intraluminal fibrosis. A model for the study of bronchiolitis obliterans organizing pneumonia. Am J Pathol 150:2243–2254

    PubMed  CAS  Google Scholar 

  6. Bertozzi P, Astedt B, Zenzius L, Lynch K, Lemaire F, Zapol W, Chapman HAJ (1990) Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. N Engl J Med 322:890–897

    Article  PubMed  CAS  Google Scholar 

  7. Carre PC, King TE Jr., Mortensesen R, Riches DWH (1994) Cryptogenic organizing pneumonia: increased expression of interleukin-8 and fibronectin genes by alveolar macrophages. Am J Respir Cell Mol Biol 10:100–105

    PubMed  CAS  Google Scholar 

  8. Cirino G, Cicala C, Bucci M, Sorrentino L, Ambrosini G, DeDominicis G, Altieri DC (1997) Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo. J Clin Invest 99:2446–2451

    Article  PubMed  CAS  Google Scholar 

  9. Cordier JF (1993) Cryptogenic organizing pneumonitis. Bronchiolitis obliterans organizing pneumonia. Clin Chest Med 14:677–692

    PubMed  CAS  Google Scholar 

  10. Cordier JF, Loire R, Brune J (1989) Idiopathic bronchiolitis obliterans organizing pneumonia. Definition of characteristic clinical profiles in a series of 16 patients. Chest 96: 999–1004

    Article  PubMed  CAS  Google Scholar 

  11. Cordier JF, Peyrol S, Loire R (1994) Bronchiolitis obliterans organizing pneumonia as a model of inflammatory lung disease. In: Epler GR (ed) Diseases of the bronchioles. Raven Press, New York, pp 313–345

    Google Scholar 

  12. Davison AG, Heard BE, McAllister WAC, Turner-Warwick ME (1983) Cryptogenic organizing pneumonitis, Q J Med 52:382–394

    PubMed  CAS  Google Scholar 

  13. Desmouliere A, Gabbiani G (1994) Modulation of fibroblastic cytoskeletal features during pathological situations: the role of extracellular matrix and cytokines. Cell Motil Cytoskeleton 29:195–203

    Article  PubMed  CAS  Google Scholar 

  14. Edwards DRG, Murphy G, Reynolds JJ, Whitham SE, Docherty AJP, Angel P, Heath JK (1987) Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. Embo J 6:1899–1904

    PubMed  CAS  Google Scholar 

  15. Eitzman DT, McCoy RD, Zheng X, Fay WP, Shen T, Ginsburg D, Simon RH (1996) Bleomycininduced pulmonary fibrosis in trangenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 97:232–237

    Article  PubMed  CAS  Google Scholar 

  16. Emonard H, Takiya C, Dreze S, Cordier JF, Grimaud JA (1989) Interstitial collagenase (MMP-1), gelatinase (MMP-2) and stromelysin (MMP-3) released by human fibroblasts cultured on acellular sarcoid granulomas (sarcoid matrix complex, SMC). Matrix 9:382–388

    Article  PubMed  CAS  Google Scholar 

  17. Epler GR, Colby TV, McLoud TC, Carrington CB, Gaensler EA (1985) Bronchiolitis obliterans organizing pneumonia. N Engl J Med 312:152–158

    Article  PubMed  CAS  Google Scholar 

  18. Floyd R (1922) Organization of pneumonic exudates. Am J Med Sci 163:527–548

    Article  Google Scholar 

  19. Fukuda Y, Ishizaki M, Masuda Y, Kimura G, Kawanami O, Masugi Y (1987) The role of intra-alveolar fibrosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage. Am J Pathol 126:171–182

    PubMed  CAS  Google Scholar 

  20. Idell S, Gonzalez K, Bradford H, MacArthur CK, Fein AM, Maunder RJ, Garcia JG, Griffith DE, Weiland J, Martin TR (1987) Procoagulant activity in bronchoalveolar lavage in the adult respiratory distress syndrome: contribution of tissue factor associated with factor VII. Am Rev Respir Dis 136:1466–1474

    Article  PubMed  CAS  Google Scholar 

  21. Idell S, Peters J, James KJ, Fair DS, Coalson JJ (1989) Local abnormalities of coagulation and fibrinolytic pathways that promote alveolar fibrin deposition in the lungs of baboons with diffuse alveolar damage. J Clin Invest 84:181–193

    Article  PubMed  CAS  Google Scholar 

  22. Idell S, Peterson BT, Gonzalez KK, Gray LD, Bach R, McLarty J, Fair DS (1988) Local abnormalities of coagulation and fibrinolysis and alveolar fibrin deposition in sheep with oleic acid-induced lung injury. Am Rev Respir Dis 138:1282–1284

    PubMed  CAS  Google Scholar 

  23. Kapanci Y, Desmouliere A, Pache JC, Redard M, Gabbiani G (1994) Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha. Am J Respir Grit Care Med 152:2163–2169

    Google Scholar 

  24. Katzenstein AL, Myers JL, Prophet WD, Corley LS III, Shin MS (1986) Bronchiolitis obliterans and usual interstitial pneumonia. A comparative clinicopathologic study. Am J Surg Pathol 10:373–381

    Article  PubMed  CAS  Google Scholar 

  25. Kuhn C, Mason RJ (1995) Immunolocalization of SPARC, tenascin, and thrombospondin in pulmonary fibrosis. Am J Pathol 147:1759–1769

    PubMed  CAS  Google Scholar 

  26. Kuhn C, McDonald JA (1991) The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis. Am J Pathol 138:1257–1265

    PubMed  CAS  Google Scholar 

  27. Laennec RTH (1826) Traité de l’Auscultation Médiate et des Maladies des Poumons et du Coeur. Chaudet 2nd edn, Paris

    Google Scholar 

  28. Leavell KJ, Peterson MW, Gross TJ (1996) The role of fibrin degradation products in neutro-phil recruitment to the lung. Am J Respir Cell Mol Biol 14:53–60

    PubMed  CAS  Google Scholar 

  29. Meduri GU, Belenchia JM, Estes RJ, Wunderink RG, El Torky M, Leeper KVJ (1991) Fibroproliferative phase of ARDS. Clinical findings and effects of corticosteroids, Chest 100: 943–952

    Article  PubMed  CAS  Google Scholar 

  30. Milne LS (1911) Chronic pneumonia (including a discussion of two cases of syphilis of the lung). Am J Med Sci 142:408–438

    Article  Google Scholar 

  31. Myers JL, Katzenstein AL (1988) Ultrastructural evidence of alveolar epithelial injury in idiopathic bronchiolitis obliterans organizing pneumonia. Am J Pathol 132:102–109

    PubMed  CAS  Google Scholar 

  32. Ohta K, Mortenson RL, Clark RAF, Hirose N, King TE, Jr (1995) Immunohistochemical identification and characterization of smooth muscle-like cells in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 152:1659–1665

    PubMed  CAS  Google Scholar 

  33. Olman MA, Mackman N, Gladson CL, Moser KM, Loskutoff DJ (1995) Changes in pro-coagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse. J Clin Invest 96:1621–1630

    Article  PubMed  CAS  Google Scholar 

  34. Peyrol S, Cordier JF, Grimaud JA (1990) Intra-alveolar fibrosis of idiopathic bronchiolitis obliterans-organizing pneumonia. Cell-matrix patterns. Am J Pathol 137:155–170

    PubMed  CAS  Google Scholar 

  35. Postlethwaite AE, Lachman LB, Mainardi CL, Kang AH (1983) Interleukin 1 stimulation of collagenase production by cultured fibroblasts. J Exp Med 157:801–806

    Article  PubMed  CAS  Google Scholar 

  36. Schmitt-Graff A, Desmouliere A, Gabbiani G (1994) Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity. Virchows Arch 425:3–24

    Article  PubMed  CAS  Google Scholar 

  37. Sitrin RG, Brubaker PG, Fantone JC (1987) Tissue fibrin deposition during acute lung injury in rabbits and its relationship to local expression of procoagulant and fibrinolytic activities. Am Rev Respir Dis 135:930–936

    PubMed  CAS  Google Scholar 

  38. Svee K, White J, Vaillant P, Jessurun J, Roongta U, Krumwiede M, Johnson D, Henke C (1996) Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44. J Clin Invest 98:1713–1727

    Article  PubMed  CAS  Google Scholar 

  39. Unemori EN, Pickford LB, Salles AL, Piercy CE, Grove BH, Erikson ME, Amento EP (1996) Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J Clin Invest 98:2739–2745

    Article  PubMed  CAS  Google Scholar 

  40. Vassali JD, Sappino AP, Belin D (1991) The plasminogen activator/plasmin system. J Clin Invest 1067–1072

    Google Scholar 

  41. Xing Z, Tremblay GM, Sime PJ, Gauldie J (1997) Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-β1 and myofibroblast accumulation. Am J Pathol 150:59–66

    PubMed  CAS  Google Scholar 

  42. Zhang H-Y, Gharaee-Kermani M, Zhang K, Karmiol S, Phan SH (1996) Lung fibroblast α-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis. Am J Pathol 148:527–537

    PubMed  CAS  Google Scholar 

  43. Zhang K, Flanders KC, Phan SH (1995) Cellular localization of transforming growth factor-β expression in bleomycin-induced pulmonary fibrosis. Am J Pathol 147:352–361

    PubMed  CAS  Google Scholar 

  44. Zhang K, Rekhter MD, Gordon D, Phan SH (1994) Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study. Am J Pathol 145:114–125

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. J.-F. Cordier
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. GREF, Université Victor Segalen Bordeaux 2, 146, Rue Léo-Saignat, 33076, Bordeaux Cedex, France

    Alexis Desmoulière

  2. Départment de Nutrition, Université de Montréal, Pavillon Liliane-de-Stewart C. P. 6128, Succursale Centre-Ville, Montréal, Québec, H3C 3J7, Canada

    Beatriz Tuchweber

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Cordier, JF. (1999). The Concept of Organizing Pneumonia. In: Desmoulière, A., Tuchweber, B. (eds) Tissue Repair and Fibrosis. Current Topics in Pathology, vol 93. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58456-5_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58456-5_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63603-5

  • Online ISBN: 978-3-642-58456-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation