What’s New in Human Wound-Healing Myofibroblasts?

  • V. Moulin
  • D. Garrel
  • F. A. Auger
  • M. O’Connor-McCourt
  • G. Castilloux
  • L. Germain
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 93)


During wound healing and fibrocontractive diseases, clinical and experimental investigations have shown that fibroblastic cells acquire some morphological and biochemical features similar to those of smooth muscle cells [33]. These modified fibroblasts, called myofibroblasts, express de novo α-SM actin temporarily during wound healing and permanently in fibrotic situations, such as hypertrophic scars or fibromatosis. Myofibroblasts are thought to be involved in contraction and have been observed in practically all fibrotic conditions involving retraction and reorganization of connective tissues [32].


Stress Fiber Dermal Fibroblast Hypertrophic Scar Human Dermal Fibroblast Normal Fibroblast 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • V. Moulin
  • D. Garrel
  • F. A. Auger
  • M. O’Connor-McCourt
  • G. Castilloux
  • L. Germain

There are no affiliations available

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