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Myofibroblastic Differentiation and Extracellular Matrix Deposition in Early Stages of Cholestatic Fibrosis in Rat Liver

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Book cover Tissue Repair and Fibrosis

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 93))

Abstract

Many studies have described changes in the hepatic extracellular matrix (ECM) and the cells involved in its production during liver injury [1, 2]. In acute liver damage, there may be complete parenchymal regeneration, scar formation, or a combination of both, and fibrogenesis seems to be transient [3]. Several cells of the liver can produce various ECM components. However, the hepatic stellate cell (HSC, also known as Ito or fat-storing cell) is the main source of ECM [24, 25] and has been shown to play a role in fibrogenesis for wound repair in acute injury of the liver [2, 18]. The HSCs can proliferate and rapidly express α smooth muscle (SM) actin, which is indicative of the cell’s involvement in matrix deposition [2, 25–27].

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Authors
  1. B. Tuchweber
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  2. A. Desmoulière
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  3. A. M. A. Costa
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  4. I. M. Yousef
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  5. G. Gabbiani
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Editor information

Editors and Affiliations

  1. GREF, Université Victor Segalen Bordeaux 2, 146, Rue Léo-Saignat, 33076, Bordeaux Cedex, France

    Alexis Desmoulière

  2. Départment de Nutrition, Université de Montréal, Pavillon Liliane-de-Stewart C. P. 6128, Succursale Centre-Ville, Montréal, Québec, H3C 3J7, Canada

    Beatriz Tuchweber

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© 1999 Springer-Verlag Berlin Heidelberg

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Tuchweber, B., Desmoulière, A., Costa, A.M.A., Yousef, I.M., Gabbiani, G. (1999). Myofibroblastic Differentiation and Extracellular Matrix Deposition in Early Stages of Cholestatic Fibrosis in Rat Liver. In: Desmoulière, A., Tuchweber, B. (eds) Tissue Repair and Fibrosis. Current Topics in Pathology, vol 93. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58456-5_11

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  • DOI: https://doi.org/10.1007/978-3-642-58456-5_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63603-5

  • Online ISBN: 978-3-642-58456-5

  • eBook Packages: Springer Book Archive

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