Abstract
The activity of connective tissue cells is controlled by numerous factors in their environment. Soluble molecules, such as hormones, growth factors and cytokines, may interact with specific receptors at the cell surface. This interaction may activate the various intracellular transduction pathways and finally modulate the expression of some specific genes. Other extracellular signals are provided by the insoluble extracellular matrix macromolecules, e.g., collagens, elastin, proteoglycans and connective tissue glycoproteins. These insoluble molecules, when interacting with specific membrane receptors of the integrin family, are able to activate similar intracellular transduction pathways to their soluble counterparts.
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© 1999 Springer-Verlag Berlin Heidelberg
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Siméon, A. et al. (1999). Fibroblast — Cytokine — Extracellular Matrix Interactions in Wound Repair. In: Desmoulière, A., Tuchweber, B. (eds) Tissue Repair and Fibrosis. Current Topics in Pathology, vol 93. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58456-5_10
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DOI: https://doi.org/10.1007/978-3-642-58456-5_10
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