Abstract
The pancreas is an organ with both exocrine and endocrine functions. The exocrine pancreas plays an essential role in the digestion and absorption of nutrients through the secretion into the proximal duodenum of digestive enzymes and bicarbonates. The endocrine pancreas, on the other hand, releases hormones that regulate metabolism and the distribution of the breakdown products of food within the body. These combined exocrine and endocrine functions make the pancreas one of the most important organs involved in the assimilation of food.
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References
Anasgnostides A, Chadwick V, Seiden AC, Maton PN (1984) Sham feeding and pancreatic secretion. Gastroenterology 87:109–114
Andrews CJH, Andrews WHH (1971) Receptors activated by acid in the duodenal wall of rabbits. QJ Exp Physiol 56:221–230
Andrews PLR, Grundy D, Scratcherd T (1980) Vagal afferent discharge from mechanoreceptors in different regions of the ferret stomach. J Physio (Lond) 298:513–524
Baca I, Feurle GE, Hass M, Nemitz T (1983) Interaction of neurotensin, cholecystokinin and secretin in the stimulation of pancreas exocrine in the dog. Gastroenterology 84:556–561
Basso N, Gini S, Improta G. et al. (1975) External Pancreatic secretion after bombesin infusion in man. Gut 16:994–998
Beglinger C, Fried M, Whitehouse I, Jansen JB, Caners CB, Gyr K (1985) Pancreatic enzyme response to a liquid meal and to hormoral stimulation. Correlation with plasma secretion and cholecystokinin level. J Clin Invest 75:147–1476
Borgstrom B (1975) On the interactions between pancreatic lipase and colipase and the substrate and the importance of bile salts. J Lipid Res 16:411–417
Borgstrom B, Donner J (1975) Binding of bile salts to pancreatic colipase and lipase. J Lipid Res 16:287–292
Chariot J, Roze C, de la Tour J, Vaille C (1982) Stimulation vagale non cholinergique de la secretion pancreatique externe chez la rat. Gastroenterol Clin Biol 6:371–378
Chey WY (1986) Hormoral control of pancreatic exocrine secretion: In: Go VLW et al. (eds) The exocrine pancreas: biology, pathobiology and diseases. Raven, New York, pp 301–313
Chey WY, Kim MS, Lee KY (1979) Influence of the vagus nerve on the release and action of secretin in dog. J Physiol 293:435–446
Debas HT, Grossman MI (1973) Pure cholecystokinin: pancreatic protein and bicarbonate response. Digestion 6:469–481
DeFillipi C, Solomon TE, Valenzuela JE (1982) Pancreatic secretory response to sham feeding in humans. Digestion 23:217–223
DiMagno EP, Go VLW, Summerskill WHJ (1973) Intraluminal and post absorptive effects of amino acids on pancreatic enzyme secretion. J Lab Clin Med 82:241–248
Dollinger HC, Raptis S, Pfeiffer EF (1976) Effects of somatostatin on exocrine and endocrine function stimulated by intestinal hormones in man. Horm Metab Res 8:74–78
Dyck WP, Texter EC, Lasater JM, Hightower NC (1970) Influence of glucagon and pancreatic exocrine secretion in man. Gastroenterology 58:532–539
Fahrenkrug J, Schaffalizky de Muckadell OB, Rune SJ (1978) pH treshold for release of secretin in normal subjects and in patients with duodenal ulcer and patients with chronic pancreatitis. Scand J Gastroenterol 13:177–186
Fletcher DR, Blackburn AM, Adrian TE, Chadwick VS, Bloon SR (1981) Effects of neurotensin on pancreatic function in man. Life Sci 29:2157–2161
Hanssen LE (1980) Pure synthetic bile salts release immunore-active secretin in man. Scand J Gastroenterol 15:461–463
Harper AA, Hood AJC, Mushens J, Smy JR (1979) Inhibition of external pancreatic secretion by intracolonic and intraileal infusion in the cat. J Physiol (Lond) 292:445–454
Holst JJ (1986) Neural regulation of pancreatic exocrine function. In: Go VLW et al. (eds) The exocrine pancreas: biology, pathobiology and diseases. Raven, New York, pp 287–300
Hootman SR, Williams JA (1987) Stimulus-secretion coupling in the pancreatic acinus. In: Johnson LR (ed) Physiology of the gasrointestinal tract, 2nd edn. Raven, New York, pp 1129–1145
Kelly RB (1985) Pathways of protein secretion in eukaryotes. Science 230:25–32
Louie DS, May D, Miller P, et al. (1986) Cholecystokinin mediates feedback regulation of pancreatic enzyme secretion in rats. Am J Physiol 250:G252-G259
Lu L, Louie D, Owyang C (1989) A cholecystokinin releasing peptide mediates feedback regulation of pancreatic secretion. Am J Physiol 256:G430-G435
MacGregor I, Parent J, Meyer JH (1977) Gastric emptying of liquid meals and pancreatic and biliary secretion after subtotal gastrectomy or truncal vagotomy and pyloroplasty in man. Gastroenterology 72:-195–198
Malagelada JR, Go VLW, Summerskill H J (1974) Altered pancreatic and biliary function after vagatomy and pyrolo-plasty. Gastroenterology 66:22–27
Owyang C, Williams J (1991) Pancreatic secretion. In: Yamada T, Alters DH, Owyang S, Powell DW, Silverstein FE (eds) Textbook of gastroenterology. J.B. Lippincott, Philadelphia, 294–314
Owyang C, Louie DS, Tatum D (1986a) Feedback regulation of pancreatic enzyme secretion in man: suppression of cholecystokinin release by trypsin. J Clin Invest 77:2042–2047
Owyang C, May D, Louie DS (1986b) Trypsin suppression of pancreatic enzyme secretion. Gastroenterology 91:637–643
Palade GE (1975) Intracellular aspects of the process of protein synthesis. Science 189:347–358
Rinderknecht H (1986) Pancreatic secretory enzymes. In: GO VL et al. (eds) The exocrine pancreas: biology, pathobiology and diseases. Raven, New York, pp 163–183
Rosenberg IR, Zambrano VJ, Janowitch HD, Rudick J (1976) Parasympathetic innervation and pancreatic secretion: the role of the gastric antrum. Ann Surg 183:247–251
Sarles H, Dani R, Prezelin G, Souville C, Figarella C (1968) Cephalic phase of pancreatic secretion in man. Gut 9:214
Schaffalizky de Muckadell OB, Fahrenkrug J (1978) Secretion pattern of secretin in man. Regulation by gastric acid. Gut 19:812–818
Schaffalizky de Muckadell OB, Fahrenkrug J, Watt-Boolsen S, Worning H (1978) Pancreatic response and plasma secretin concentration during infusion of low dose secretin in man. Scand J Gastroenterol 13:305–311
Schaffalizky de Muckadell OB, Fahrenkrug J, Nielsen J, Westfall, Worning H (1981) Meal-stimulated secretin release in man: effect of acid and bile. Scand J Gastroenterol 16:981–988
Scheele G (1986) Cellular processing of proteins in the exocrine pancreas. In: Go VL et al. (eds) The exocrine pancreas: biology, pathobiology and diseases. Raven, New York, pp 69–85
Scheele G, Bartelt D, Bieger W (1981) Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis. Gastroenterology 80:461–473
Schulz I (1987) Electrolyte and fluid secretion in the exocrine pancreas. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 1147–1171
Schwartz TW (1983) Pancreastic polypeptide: a hormone under vagal control. Gastroenterology 85:1411–1425
Singer MV (1986) Neurohormonal control of pancreatic enzyme secretion in animals. In: Go VLW et al. (eds) The exocrine pancreas: biology, pathobiology and diseases. Raven, New York, pp 315–331
Walsh JH, Laners CB, Valenzuela JE (1982) Cholecystectokinin-octapeptide-like immunoreactivity in human plasma. Gastroenterology 82:438–444
Watanbe S, Chey WY, Lee KY, Chang TM (1986) Secretin is released by digestive products of fat in dog. Gastroenterology 90:1008–1017
White TT, McAlexander RA, Magee DF (1963) The effects of gastric distension on duodenal aspirates in man. Gastroenterology 44:48–53
You CH, Rominger JM, Chey WY (1982) Effects of atropine on the action and release of secretin in humans. Am J Physiol 242:608–611
Zimmerman MJ, Jonowitz HD (1986) Water and electrolyte secretion in the human pancreas. In: Go VL et al. (eds) The exocrine pancreas: biology, pathobiology and diseases. Raven, New York, pp 275–281
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Bernard, P.H. (1999). Physiology of the Exocrine Pancreas. In: Baert, A.L., Delorme, G., Van Hoe, L. (eds) Radiology of the Pancreas. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58380-3_2
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DOI: https://doi.org/10.1007/978-3-642-58380-3_2
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