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Ovarian Stimulation for In Vitro Fertilization: Past and Present

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Manual on Assisted Reproduction

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Abstract

Initially, “test tube babies” were born from pregnancies conceived by in vitro fertilization (IVF) of oocytes obtained from spontaneous, nonstimulated cycles (Steptoe and Edwards 1978; Lopata et al. 1980). Subsequently, the pioneers of IVF enhanced the efficacy of this procedure by developing methods for the hormonal stimulation of the ovaries. This treatment made the simultaneous development and fertilization of several oocytes possible, with the ultimate goal of transferring more than one embryo (Fishel et al. 1985). Thus, instead of the selection and development of a single dominant follicle, as seen in the spontaneous menstrual cycle, the primary objective of ovarian stimulation for IVF treatment has been, and still is, to promote the selection and simultaneous development of several dominant follicles during the same menstrual cycle.

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  1. J. Urbancsek
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  2. T. Rabe
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  3. T. Strowitzki
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  1. Division of Gynecology and Reproductive Medicine, University Women’s Hospital, Voss-Straße 9, 69115, Heidelberg, Germany

    Thomas Rabe  & Thomas Strowitzki  & 

  2. Department Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany

    Klaus Diedrich

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Urbancsek, J., Rabe, T., Strowitzki, T. (2000). Ovarian Stimulation for In Vitro Fertilization: Past and Present. In: Rabe, T., Diedrich, K., Strowitzki, T. (eds) Manual on Assisted Reproduction. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58341-4_6

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