Abstract
Myeloperoxidase (MPO) is an abundant constituent (up to 5% of dry weight) of polymorphonuclear leukocytes [1]. In conjunction with phagocyte-generated hydrogen peroxide and any of several cofactors, the enzyme catalyzes the formation of a broad array of microbicidal products. The number of potentially microbicidal products exceeds the several effective cofactors implicated, including the halides chloride, bromide, iodide, the pseudohalide thiocyanate, and nitrite [1, 2]. The in vivo relevance of the cofactors based on their anticipated physiologic concentrations is open to debate. Chloride, however, is clearly available at the greater than to mM concentrations required for it to be an effective MPO cofactor.
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Rosen, H. (2000). Targets for Myeloperoxidase-Dependent Bactericidal Activity. In: Petrides, P.E., Nauseef, W.M. (eds) The Peroxidase Multigene Family of Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58314-8_7
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DOI: https://doi.org/10.1007/978-3-642-58314-8_7
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