Abstract
Neutrophils possess potently active biological systems able to kill in vitro tumors as well as a wide range of microorganisms, including bacteria, fungi [1-3], and viruses [4-6]. To this end, neutrophils utilize directly microbicidal granule proteins as well as a variety of reactive oxygen intermediates. However, the most efficient oxygen-dependent system exploits the combined effects of hydrogen peroxide, generated by activation of the NADPH-dependent oxidase, and the granule protein myeloperoxidase (MPO; E.C. 1.11.1.7).
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Suzuki, K., Nunoi, H., Miyazaki, M., Koi, F. (2000). Prevalence of Inherited Myeloperoxidase Deficiency in Japan. In: Petrides, P.E., Nauseef, W.M. (eds) The Peroxidase Multigene Family of Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58314-8_20
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DOI: https://doi.org/10.1007/978-3-642-58314-8_20
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