Calmodulin-Dependent Protein Kinases

  • Joachim Krebs
Part of the Topics in Biological Inorganic Chemistry book series (TBIC, volume 3)


Protein-dependent kinases are key regulators of many cellular events. One important class, the calmodulin-dependent protein kinases (CaMkinases), is dependent on changes of the intracellular concentrations of the second messenger Ca2+. In this chapter the structural and functional properties of CaMkinases are summarized. The different kinases known to date can be either monospecific for one substrate or multifunctional, recognizing a number of different substrates. CaMkinases are involved in the regulation of many different cellular processes such as neurotransmitter release, muscle contraction, cell proliferation, gene expression, and long term potentiation and depression. Their participation in these different regulatory pathways are evaluated.


Calmodulin Calmodulin-dependent protein kinase (CaMK) DAP-kinase Gene expression Synaptic plasticity Apoptosis 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Joachim Krebs
    • 1
  1. 1.Institute of BiochemistrySwiss Federal Institute of Technology (ETH)ZurichSwitzerland

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