Skip to main content
SpringerLink
Log in

Calmodulin Target Recognition: Common Mechanism and Structural Diversity

  • Chapter
Calcium Homeostasis

Part of the book series: Topics in Biological Inorganic Chemistry ((TBIC,volume 3))

Abstract

Calmodulin is an intracellular calcium receptor which regulates the biological activities of a wide variety of proteins including protein kinases, phosphatases, and ion transporters. During the past decade, three-dimensional structures of calmodulin in forms of various target complexes have been elucidated. This review presents the latest advances in the field of calmodulin and its target proteins, with particular emphasis on the structural basis underlying multi-target recognition processes conducted by this Ca2+-dependent cellular activator.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kretsinger RH, Nockolds CE (1973) J Biol Chem 248:3313

    PubMed  CAS  Google Scholar 

  2. Copley RR, Schultz J, Ponting CP, Bork P (1999) Curr Opin Struct Biol 9:408

    PubMed  CAS  Google Scholar 

  3. Crivici A, Ikura M (1995) Ann Rev Biophys Biomol Struct 24:85

    Google Scholar 

  4. Vogel HJ, Zhang M (1995) Mol CeU Biochem 149/150:3

    Google Scholar 

  5. Rhoads AR, Friedberg F (1997) FASEB J 11:331

    PubMed  CAS  Google Scholar 

  6. Means AR, VanBerkum FA, Bagchi I, Lu KP, Rasmussen CD (1991) Pharmacol Ther 50:255

    PubMed  CAS  Google Scholar 

  7. O’Neil KT, DeGrado WF (1990) Trends Biochem Sci 15:59

    PubMed  Google Scholar 

  8. Vogel HJ (1994) Biochem Cell Biol 72:357

    PubMed  CAS  Google Scholar 

  9. James P, Vorherr T, Carafoli E (1995) Trends Biochem Sci 20:38

    PubMed  CAS  Google Scholar 

  10. Ikura M (1996) Trends Biochem Sci 21:14

    PubMed  CAS  Google Scholar 

  11. Zhang M, Yuan T (1998) Biochem Cell Biol 76:313

    PubMed  CAS  Google Scholar 

  12. Babu YS, Sack JS, Greenhough TJ, Bugg CE, Means AR, Cook WJ (1985) Nature 315:37

    PubMed  CAS  Google Scholar 

  13. Kretsinger RH, Rudnick S, Weissman LJ (1986) J Inorg Biochemistry 28:289

    CAS  Google Scholar 

  14. Babu YS, Bugg CE, Cook WJ (1988) J Mol Biol 204:191

    PubMed  CAS  Google Scholar 

  15. Chattopadhyaya R, Meador WE, Means AR, Quiocho FA (1992) J Mol Biol 228:1177

    PubMed  CAS  Google Scholar 

  16. Taylor DA, Sack JS, Maune JF, Beckingham K, Quiocho FA (1991) J Biol Chem 266:21,375

    PubMed  CAS  Google Scholar 

  17. Rao ST, Wu S, Satyshur KA, Ling K-Y, Kung C, Sundaralingam M (1993) Prot Sci 2:436

    CAS  Google Scholar 

  18. Ban C, Ramakrishnan B, Ling K-Y, Kung C, Sundaralingam M (1994) Acta Cryst D50:50

    CAS  Google Scholar 

  19. Walsh M, Stevens FC, Kuznicki J, Drabikowski W (1977) J Biol Chem 252:7440

    PubMed  CAS  Google Scholar 

  20. Drabikowski W, Kuznicki J, Grabarek Z (1977) Biochim Biophys Acta 485:124

    PubMed  CAS  Google Scholar 

  21. LaPorte DC, Wierman BM, Storm DR (1980) Biochemistry 19:3814

    PubMed  CAS  Google Scholar 

  22. Tanaka T, Hidaka H (1980) J Biol Chem 255:11,078

    PubMed  CAS  Google Scholar 

  23. Heidorn DB, Trewhella J (1988) Biochemistry 27:909

    PubMed  CAS  Google Scholar 

  24. Ikura M, Spera S, Barbato G, Kay LE, Krinks M, Bax A (1991) Biochemistry 30:9216

    PubMed  CAS  Google Scholar 

  25. Spera S, Ikura M, Bax A (1991) J BioMol NMR 1:155

    PubMed  CAS  Google Scholar 

  26. Barbato G, Ikura M, Kay LE, Pastor RW, Bax A (1992) Biochemistry 31:5269

    PubMed  CAS  Google Scholar 

  27. Bayley PM, Martin SR (1992) Biochim Biophys Acta 1160:16

    PubMed  CAS  Google Scholar 

  28. Herzberg O, Moult J, James MN (1986) J Biol Chem 261:2638

    PubMed  CAS  Google Scholar 

  29. Finn BE, Evenas J, Drakenberg T, Waltho JP, Thulin E, Forsen S (1995) Nat Struct Biol 2:777

    PubMed  CAS  Google Scholar 

  30. Kuboniwa H, Tjandra N, Grzesiek S, Ren H, Klee CB, Bax A (1995) Nat Struct Biol 2:768

    PubMed  CAS  Google Scholar 

  31. Zhang M, Tanaka T, Ikura M (1995) Nat Struct Biol 2:758

    PubMed  CAS  Google Scholar 

  32. Trave G, Lacombe PJ, Pfuhl M, Saraste M, Pastore A (1995) EMBO J 14:4922

    PubMed  CAS  Google Scholar 

  33. Tanaka T, Ames JB, Harvey TS, Stryer L, Ikura M (1995) Nature 376:444

    PubMed  CAS  Google Scholar 

  34. Ames JB, Ishima R, Tanaka T, Gordon JI, Stryer L, Ikura M (1997) Nature 389:198

    PubMed  CAS  Google Scholar 

  35. Gagne SM, Li MX, McKay RT, Sykes BD (1998) Biochem Cell Biol 76:302

    PubMed  CAS  Google Scholar 

  36. Smith SP, Shaw GS (1998) Biochem Cell Biol 76:324

    PubMed  CAS  Google Scholar 

  37. Yap KL, Ames JB, Swindells MB, Ikura M (1999) Proteins 37:499

    PubMed  CAS  Google Scholar 

  38. Skelton NJ, Kördel J, Akke M, Forsén S, Chazin WJ (1994) Nat Struct Biol 1:239

    PubMed  CAS  Google Scholar 

  39. Urbauer JL, Short JH, Dow LK, Wand AJ (1995) Biochemistry 34:8099

    PubMed  CAS  Google Scholar 

  40. Tjandra N, Kuboniwa H, Ren H, Bax A (1995) Eur J Biochem 230:1014

    PubMed  CAS  Google Scholar 

  41. Tsalkova TN, Privalov P (1985) J Mol Biol 181:533

    PubMed  CAS  Google Scholar 

  42. Swindells MB, Ikura M (1996) Nat Struct Biol 3:501

    PubMed  CAS  Google Scholar 

  43. Yuan T, Ouyang H, Vogel HJ (1999) J Biol Chem 274:8411

    PubMed  CAS  Google Scholar 

  44. Yuan T, Walsh MP, Sutherland C, Fabian H, Vogel HJ (1999) Biochemistry 38:1446

    PubMed  CAS  Google Scholar 

  45. Stull JT, Kamm KE, Krueger JK, Lin P, Luby-Phelps K, Zhi G (1997) Adv Second Messenger Phosphoprotein Res 31:141

    PubMed  CAS  Google Scholar 

  46. Ikura M, Clore GM, Gronenborn AM, Zhu G, Klee CB, Bax A (1992) Science 256:632

    PubMed  CAS  Google Scholar 

  47. Gellman SH (1991) Biochemistry 30:6633

    PubMed  CAS  Google Scholar 

  48. Meador WE, Means AR, Quiocho FA (1992) Science 257:1251

    PubMed  CAS  Google Scholar 

  49. Meador WE, Means AR, Quiocho FA (1993) Science 262:1718

    PubMed  CAS  Google Scholar 

  50. Braun AP, Schulman H (1995) Ann Rev Physiol 57:417

    CAS  Google Scholar 

  51. Quiocho FA, Johnson KA, Meador WE, Beckingham K (1997) Proceedings of the 10th International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease, Lund, Sweden, p 27

    Google Scholar 

  52. Scaloni A, Miraglia N, Orru S, Amodeo P, Motta A, Marino G, Pucci P (1998) J Mol Biol 277:945

    PubMed  CAS  Google Scholar 

  53. Osawa M, Tokumitsu H, Swindells MB, Kurihara H, Orita M, Shibanuma T, Furuya T, Ikura M (1999) Nat Struct Biol 6:819

    PubMed  CAS  Google Scholar 

  54. Soderling TR (1999) Trends Biochem Sci 24:232

    PubMed  CAS  Google Scholar 

  55. Elshorst B, Hennig M, Forsterling H, Diener A, Maurer M, Schulte P, Schwalbe H, Griesinger C, Krebs J, Schmid H, Vorherr T, Carafoli E (1999) Biochemistry 38:12,320

    PubMed  CAS  Google Scholar 

  56. Kataoka M, Head JF, Vorherr T, Krebs J, Carafoli E (1991) Biochemistry 30:6247

    PubMed  CAS  Google Scholar 

  57. Heidorn DB, Seeger PA, Rokop SE, Blumenthal DK, Means AR, Crespi H, Trewhella J (1989) Biochemistry 28:6757

    PubMed  CAS  Google Scholar 

  58. Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW, Gastinel LN, Habuka N, Chen X, Maldonado F, Barker JE, Bacquet R, Villafranca JE (1995) Nature 378:641

    PubMed  CAS  Google Scholar 

  59. Zhang G, Liu Y, Ruoho AE, Hurley JH (1997) Nature 386:247

    PubMed  CAS  Google Scholar 

  60. Goldberg J, Nairn AC, Kuriyan J (1996) Cell 84:875

    PubMed  CAS  Google Scholar 

  61. Yuan Y, Weljie AM, Vogel HJ (1998) Biochemistry 37:3187

    PubMed  CAS  Google Scholar 

  62. Bayley PM, Findlay WA, Martin SR (1996) Prot Sci 5:1215

    CAS  Google Scholar 

  63. Mayans 0, van der Ven FM, Wilm M, Mues A, Young P, Furst DO, Wilmanns M, Gautel M (1998) Nature 395:863

    PubMed  CAS  Google Scholar 

  64. Levin RM, Weiss B (1977) Mol Pharmacol 13:690

    PubMed  CAS  Google Scholar 

  65. Hidaka H, Yamaki T, Naka M, Tanaka T, Hayashi H, Kobayashi R (1979) Mol Pharmacol 17:66

    Google Scholar 

  66. Vandonselaar M, Hickie RA, Quail JW, Delbaere LTJ (1994) Nat Struct Biol 1:795

    PubMed  CAS  Google Scholar 

  67. Cook WJ, Walter LJ, Walter MR (1994) Biochemistry 33:15,259

    PubMed  CAS  Google Scholar 

  68. Vertessy BG, Harmat V, Bocskei Z, Naray-Szabo G, Orosz F, Ovadi J (1998) Biochemistry 37:15,300

    PubMed  CAS  Google Scholar 

  69. Osawa M, Swindells MB, Tanikawa J, Tanaka T, Mase T, Furuya T, Ikura M (1998) J Mol Biol 276:165

    PubMed  CAS  Google Scholar 

  70. Osawa M, Kuwamoto S, Izumi Y, Yap KL, Ikura M, Shibanuma T, Yokokura H, Hidaka H, Matsushima N (1999) FEBS Lett 4 4(2):173

    Google Scholar 

  71. Blackshear PJ (1993) J Biol Chem 268:1501

    PubMed  CAS  Google Scholar 

  72. Porumb T, Crivici A, Blackshear PJ, Ikura M (1997) Eur Biophys J 25:239

    PubMed  CAS  Google Scholar 

  73. Matsubara M, Yamauchi E, Hayashi N, Taniguchi H (1998) FEBS Lett 421:203

    PubMed  CAS  Google Scholar 

  74. Schleiff E, Schmitz A, McIlhinney RA, Manenti S, Vergeres G (1996) J Biol Chem 271:26,794

    PubMed  CAS  Google Scholar 

  75. Wang KL, Khan MT, Roufogalis BD (1997) J Biol Chem 272:16,002

    PubMed  CAS  Google Scholar 

  76. Bunting MD, Zhang S, Bernhardt JP, Huganir RL (1996) J Biol Chem 271:10,230

    PubMed  CAS  Google Scholar 

  77. Matsuoka Y, Hughes CA, Bennett V (1996) J Biol Chem 271:25,157

    PubMed  CAS  Google Scholar 

  78. Joshi R, Bennett V (1990) J Biol Chem 265:13,130

    PubMed  CAS  Google Scholar 

  79. Dong L, Chapline C, Mousseau B, Fowler L, Ramsay K, Stevens JL, Jaken S (1995) J Biol Chem 270:25,534

    Google Scholar 

  80. Ehlers MD, Zhang S, Bernhardt JP, Huganir RL (1996) Cell 84:745

    PubMed  CAS  Google Scholar 

  81. Grunwald ME, Yu W-P, Yu H-H, Yau K-W (1998) J Biol Chem 273:9148

    PubMed  CAS  Google Scholar 

  82. Xia X-M, Fakler B, Rivard A, Wayman G, Johnson-Pais T, Keen JE, Ishii T, Hirschberg B, Bond CT, Lutsenko S, Maylie J, Adelman JP (1998) Nature 395:503

    PubMed  CAS  Google Scholar 

  83. Khanna R, Chang MC, Joiner WJ, Kaczmarek LK, Schlichter LC (1999) J Biol Chem 274:14,838

    PubMed  CAS  Google Scholar 

  84. Fänger CM, Ghanshani S, Logsdon NJ, Rauer H, Kaiman K, Zhou J, Beckingham K, Chandy KG, Cahalan MD, Aiyar J (1999) J Biol Chem 274:5746

    PubMed  Google Scholar 

  85. Trost C, Marquart A, Zimmer S, Philipp S, Cavalie A, Flockerzi V (1999) FEBS Lett 451:257–263

    PubMed  CAS  Google Scholar 

  86. Peterson BZ, DeMaria CD, Yue, DT (1999) Neuron 22:549

    PubMed  CAS  Google Scholar 

  87. Qin N, Olcese R, Bransby M, Lin T, Birnbaumer L (1999) Proc Natl Acad Sci 96:2435

    PubMed  CAS  Google Scholar 

  88. Zuhlke RD, Pitt GS, Deisseroth K, Tsien RW, Reuter H (1999) Nature 399:159

    PubMed  CAS  Google Scholar 

  89. Lee A, Wong ST, Gallagher D, Li B, Storm DR, Scheuer T, Catterall WA (1999) Nature 399:155

    PubMed  CAS  Google Scholar 

  90. Baum G, Lev-Yadun S, Fridmann Y, Arazi T, Katsnelson H, Zik M, Fromm H (1996) EMBO J 15:2988

    PubMed  CAS  Google Scholar 

  91. Baum G, Chen Y, Arazi T, Takatsuji H, Fromm H (1993) J Biol Chem 268:19,610

    PubMed  CAS  Google Scholar 

  92. Yuan T, Vogel HJ (1998) J Biol Chem 273:30,328

    PubMed  CAS  Google Scholar 

  93. Persechini A, Kretsinger RH (1988) J Biol Chem 263:12,175

    PubMed  CAS  Google Scholar 

  94. VanBerkum FA, George SE, Means AR (1990) Calmodulin activation of target enzymes. Consequence of deletions in the central helix. J Biol Chem 265:3750–3756

    CAS  Google Scholar 

  95. van der Spoel D, DeGroot BL, Hayward S, Berendsen HJ, Vogel HJ (1996) Prot Sci 5:2044

    Google Scholar 

  96. Wriggers W, Mehler E, Pitici F, Weinstein H, Schulten K (1998) Biophys J 74:1622

    PubMed  CAS  Google Scholar 

  97. Raghunathan S, Chandross RJ, Cheng B-P, Persechini A, Sobottka SE, Kretsinger RH (1993) Proc Natl Acad Sci 90:6869

    PubMed  CAS  Google Scholar 

  98. Tabernero L, Taylor DA, Chandross R, VanBerkum FA, Means AR, Quiocho FA, Sack JS (1997) Structure 5:613

    PubMed  CAS  Google Scholar 

  99. Meador WE, George SE, Means AR, Quiocho FA (1995) Nat Struct Biol 2:943

    PubMed  CAS  Google Scholar 

  100. Trewhella J, Blumenthal DK, Rokop SE, Seeger PA (1990) Biochemistry 29:9316

    Google Scholar 

  101. Zhang M, Li M, Wang JH, Vogel HJ (1994) J Biol Chem 269:15,546

    Google Scholar 

  102. Edwards RA, Walsh MP, Sutherland C, Vogel HJ (1998) Biochem J 331:149

    PubMed  CAS  Google Scholar 

  103. Chin D, Means AR (1996) J Biol Chem 271:30,465

    PubMed  CAS  Google Scholar 

  104. Chin D, Winkler KE, Means AR (1997) J Biol Chem 272:31,235

    PubMed  CAS  Google Scholar 

  105. Zhang M, Vogel HJ (1994) J Mol Biol 239:545

    PubMed  CAS  Google Scholar 

  106. Yuan T, Vogel HJ (1999) Prot Sci 8:113

    CAS  Google Scholar 

  107. Walsh MP, Stevens FC (1978) Biochemistry 17:3924

    Google Scholar 

  108. Yao Y, Yin D, Jas GS, Kuczer K, Williams TD, Schoneich C, Squier TC (1996) Biochemistry 35:2767

    PubMed  CAS  Google Scholar 

  109. Zhu T, Ikebe MA (1994) FEBS Lett 339:31

    PubMed  CAS  Google Scholar 

  110. Houdusse A, Cohen C (1995) Proc Natl Acad Sci USA 92:10,644

    PubMed  CAS  Google Scholar 

  111. Houdusse A, Silver M, Cohen C (1996) Structure 4:1475

    PubMed  CAS  Google Scholar 

  112. Tsvetkov PO, Protasevich II, Gill R, Lafitte D, Lobachov VM, Haiech J, Briand C, Makarov AA (1999) J Biol Chem 274:18,161

    Google Scholar 

  113. Persechini A, Gansz K, Paresi R (1996) J Biol Chem 271:19,279

    PubMed  CAS  Google Scholar 

  114. Zhi G, Abdullah SM, Stull JT (1998) J Biol Chem 273:8951

    PubMed  CAS  Google Scholar 

  115. Krueger J, Olah GA, Rokop SE, Zhi G, Stull JT, Trewhella J (1997) Biochemistry 36:6017

    PubMed  CAS  Google Scholar 

  116. Krueger JK, Zhi G, Stull JT, Trewhella J (1998) Biochemistry 37:13,997

    PubMed  CAS  Google Scholar 

  117. Ruan J, Xie Q-W, Hutchinson N, Cho H, Wolfe GC, Nathan C (1996) J Biol Chem 271:22,679

    Google Scholar 

  118. Lee S-J, Stull JT (1998) J Biol Chem 273:27,430

    Google Scholar 

  119. Vertessy BG, Bocskei Z, Harmath V, Naray-Szabo G, Ovadi J (1997) Proteins 28:131

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada

    Tao Yuan, Kyoko L. Yap & Mitsuhiko Ikura

Authors
  1. Tao Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kyoko L. Yap
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mitsuhiko Ikura
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biological Chemistry, University of Padova, Viale G. Colombo 3, 35121, Padova, Italy

    Ernesto Carafoli

  2. Institut für Biochemie, ETH-Zentrum, 8092, Zürich, Switzerland

    Joachim Krebs

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Yuan, T., Yap, K.L., Ikura, M. (2000). Calmodulin Target Recognition: Common Mechanism and Structural Diversity. In: Carafoli, E., Krebs, J. (eds) Calcium Homeostasis. Topics in Biological Inorganic Chemistry, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58306-3_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58306-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63532-8

  • Online ISBN: 978-3-642-58306-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation