Abstract
Denopamine is a novel phenylethanolamine derivative (Fig. 1). It is a highly selective β 1-agonist and was derived from a study on structure-activity relationships of a β 2-agonist, trimetoquinol, and was designed as an orally active positive inotropic agent with minor side effects. We report here denopamine’s pharmacological properties and mechanism of action. Denopamine has been used clinically as a remedy for chronic heart failure in Japan since 1988.
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© 1991 Springer-Verlag Berlin Heidelberg
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Nagao, T., Sasaki, Y., Yabana, H., Hoshiyama, M., Harigaya, S. (1991). Pharmacological Properties and Mechanism of Action of Denopamine in Experimental Animals. In: Lewis, B.S., Kimchi, A. (eds) Heart Failure Mechanisms and Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58231-8_22
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DOI: https://doi.org/10.1007/978-3-642-58231-8_22
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