Skip to main content
SpringerLink
Log in

Can Thrombolysis Prevent Ischemic Heart Failure?

  • Conference paper
Book cover Heart Failure Mechanisms and Management

  • 74 Accesses

Abstract

Pump failure, whether early and severe such as in acute cardiogenic shock, or insidious and late by congestion of upstream organs, is now the leading cause of cardiac death. Efforts at temporary mechanical or pharmacologic support of the heart have been largely unsuccessful so that attention is now more and more directed toward prevention of ventricular failure. When ischemic heart disease as a consequence of coronary artery obstruction(s) is the cause, limitation of the initial myocardial infarct size or even outright prevention of infarction itself appears to be the best approach now that early reperfusion efforts with thrombolytic agents have proven to be very successful in this regard.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. The MIAMI Trial Research Group (1985) Metoprolol in acute myocardial infarction. Eur Heart J 6:199–226

    Google Scholar 

  2. ISIS-I (first international study of infarct survival) collaborative group (1986) Randomised trial of intravenous atenolol among 16 027 cases of suspected acute myocardial infarction. Lancet II.57–65

    Google Scholar 

  3. The Danish Study Group on Verapamil in Myocardial Infarction (1984) Verapamil in acute myocardial infarction. Eur Heart J 5:516–528

    Google Scholar 

  4. Muller JE, Morrison J, Stone PH, Rude RE, Rosner B, Roberts R, Pearle DL, Turi ZG, Schneider JF, Serfas DH, Tate C, Scheiner E, Sobel BE, Hennekens CH, Braunwald E (1984) Nifedipine therapy for patients with threatened and acute myocardial infarction: a randomized double blind, placebo controlled comparison. Circulation 69:740–747

    Article  PubMed  CAS  Google Scholar 

  5. Muller JE, NA MIS Study Group (1985) Nifedipine therapy for unstable angina and myocardial infarction: randomized double blind evaluations. In: Hugenholtz PG, Goldstein B (eds) Unstable angina. Schattauer, Stuttgart, pp 199–210

    Google Scholar 

  6. Sirnes PA, Overskeid K, Pederson TR, Bathen J, Drivenes A, Froland GS, Kjekshus JK, Laudmark K, Rokseth R, Sirnes KE, Sundoy A, Torjussen BR, Westlund KM, Wik BA (1984) Evolution of infarct size during the early use of nifedipine in patients with acute myocardial infarction: the Norwegian nifedipine multicenter trial. Circulation 70:638–644

    Article  PubMed  CAS  Google Scholar 

  7. Simoons M L, van den Brand M, de Zwaan C, Verheught FWA, Remme WJ, Serruys PW, Bar F, Res J, Krauss XH, Vermeer F, Lubsen J (1985) Improved survival after early thrombolysis in acute myocardial infarction. Lancet I.578–582

    Article  Google Scholar 

  8. Gotsman MS, Weiss AT (1986) Immediate reperfusion in acute myocardial infarctions. Bibl Cardiol 40:30–51

    PubMed  Google Scholar 

  9. Fulton W, Lutz W, Donald KW (1972) Natural history of unstable angina. Lancet I:860–870

    Article  Google Scholar 

  10. DeWood MA, Spores J, Notske R, Mouser LT, Borroughs R, Golden MS, Lang HT (1980) Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 303:897–902

    Article  PubMed  CAS  Google Scholar 

  11. Falk E (1983) Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Br Heart J 50:127–134

    Article  PubMed  CAS  Google Scholar 

  12. Davies MJ, Thomas A (1984) Thrombosis and acute coronary artery lesions in sudden cardiac ischemic death. N Engl J Med 310:1137–1150

    Article  PubMed  CAS  Google Scholar 

  13. Sobel BE, Geltman EM, Tiefenbrunn AJ, Jaffe AS, Spadaro JJ, Ter-Pogossian MM, Collen D, Ludbrook PA (1984) Improvement of regional myocardial metabolism after coronary thrombolysis induced with tissue type plasminogen activator or streptokinase. Circulation 69:983–990

    Article  PubMed  CAS  Google Scholar 

  14. GISSI (Gruppo Italiano per to studio della streptochinasi nell’infarcto myocardico) Tognoni F, Rovelli F et al. (1986) Effectiveness of intravenous thrombolytic therapy in acute myocardial infarction. Lancet I:397–402

    Google Scholar 

  15. Kennedy JW, Ritchie JL, Davis KB, Stadius L, Maynard C, Fritz JK (1985) The Western Washington randomized trial of intracoronary streptokinase in acute myocardial infarction. N Engl J Med 312:1073–1078

    Article  PubMed  CAS  Google Scholar 

  16. Koren G, Weiss AT, Hasin Y, Appelbaum D, Welber S, Rozenman Y, Lotau C, Mosseri M, Sapoznikov D, Luria MH, Gotsman M (1985) Prevention of myocardial damage in acute myocardial ischemia by early treatment with intravenous streptokinase. N Engl J Med 313:1384–1389

    Article  PubMed  CAS  Google Scholar 

  17. Hugenholtz PG, Rentrop P (1982) Thrombolytic therapy for acute myocardial infarction: quo vadis? Eur Heart J 3:395–403

    PubMed  CAS  Google Scholar 

  18. Yusuf S, Collins R, Peto R, Furberg C, Stampfer MJ, Goldhaber SZ, Hennekes CH (1985) Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: overview of results on mortality, reinfarction and side effects from 33 randomized controlled trials. Eur Heart J 6:556–585

    PubMed  CAS  Google Scholar 

  19. Rentrop P, De Vivie ER, Karsch KR et al. (1978) Acute coronary occlusion with impending infarction as an angiographic complication relieved by a guide wire recanalization. Clin Cardiol 1:101–107

    PubMed  CAS  Google Scholar 

  20. Rentrop P, De Vivie ER, Karsch KR et al. (1979) Acute myocardial infarction: intracoronary application of nitroglycerin and streptokinase in combination with transluminal recanalization. Clin Cardiol 5:354–356

    Google Scholar 

  21. Serruys PW, van den Brand M, Hooghoudt TEH, Simoons ML, Rioretti P, Ruiter J, Fels PW, Hugenholtz PG (1982) Coronary recanalization in acute myocardial infarction: immediate results and potential risks. Eur Heart J 3:404–415

    PubMed  CAS  Google Scholar 

  22. Schwarz F, Hofmann M, Schuler G, von Olshausen K, Zimmermann R, Kubler W (1984) Thrombolysis in acute myocardial infarction: effect of intravenous followed by intracoronary streptokinase application on estimates of infarct size. Am J Cardiol 53:1505–1510

    Article  PubMed  CAS  Google Scholar 

  23. Khaja F, Walton JA, Brymer JF, Lo E, Osterberger L, O’Neill WW, Colfer HT, Weiss R, Lee T, Kurian T, Goldberg AD, Pitt B, Goldstein S (1983) Intracoronary fibrinolytic therapy in acute myocardial infarction: report of a prospective randomized trial. N Engl J Med 308:1305–1311

    Article  PubMed  CAS  Google Scholar 

  24. Merx W, Dorr R, Rentrop P, Blanke H, Karsch KR, Mathey DG, Kriemer P, Rutsch W, Schmutzler H (1981) Evaluation of the effectiveness of intracoronary streptokinase infusion in acute myocardial infarction: postprocedure management and hospital course in 204 patients. Am Heart J 102:1181–1187

    Article  PubMed  CAS  Google Scholar 

  25. Meyer J, Merx W, Schmitz H, Erbel R, Kiesslich T, Dörr R, Lambertz H, Bethge C, Krebs W, Bardos P, Minale C, Messmer BJ, Effert S (1982) Percutaneous transluminal coronary angioplasty immediately after intracoronary streptolysis of transmural myocardial infarction. Circulation 66:905–913

    Article  PubMed  CAS  Google Scholar 

  26. Kambara M, Kawai C, Kammatsuse K, Sato H, Nobuyoshi M, Chino M, Miwa H, Uchida Y, Kodama K, Mitsudo K, Hayashi T, Kajiwara N, Sekiguchi M, Yasue H (1985) Coronary thrombolysis in urokinase infusion in acute myocardial infarction. A multicenter study in Japan. Cathet Cardiovasc Diagn 11:349–360

    Article  PubMed  CAS  Google Scholar 

  27. Van der Werf F, Bergmann SR, Fox KAA, De Geest H, Hoyng CF, Sobel BE, Collen D (1984) Coronary thrombolysis with intravenously administered human tissue type plasminogen activator produced by recombinant DNA technology. Circulation 69:605–610

    Article  PubMed  Google Scholar 

  28. TIMI Study Group (1985) The thrombolysis in myocardial infarction (TIMI) trial: phase I findings. N Engl J Med 310:932–946

    Google Scholar 

  29. Verstraete M, Bory M, Collen D et al. (1985) Randomized trial of intravenous recombinant tissue-type plasminogen activator versus intravenous streptokinase in acute myocardial infarction, II. Lancet I:842–847

    Article  Google Scholar 

  30. Topol EJ, Eha JE, Brin KP et al. (1985) Applicability of percutaneous transluminal angioplasty to patients with recombinant tissue type plasminogen activator mediated thrombolysis. Cathet Cardiovasc Diagn 2:337–348

    Article  Google Scholar 

  31. Simoons ML, Serruys PW, Van den Brand M et al. (1986) Early thrombolysis in acute myocardial infarction: limitation of infarct size and improved survival. J Am Coll Cardiol 7:717–728

    Article  PubMed  CAS  Google Scholar 

  32. Serruys PW, Simoons ML, Suryapranata M et al. (1986) Preservation of global and regional left ventricular function after early thrombolysis in acute myocardial infarction. J Am Coll Cardiol 7:729–742

    Article  PubMed  CAS  Google Scholar 

  33. Vermeer F, Simoons ML, Bar FW, Tijssen JGP, Van Domburg RT, Serruys PW, Verheugt FWA, Res JCJ, De Zwaan C, Van der Laarse A, Drauss XH, Lubsen J, Hugenholtz PG (1986) Which patients benefit most from early thrombolytic therapy with intracoronary streptokinase? Circulation 74:1379–1389

    Article  PubMed  CAS  Google Scholar 

  34. The ISAM study group (1986) A prospective trial of intravenous streptokinase in acute myocardial infarction (ISAM). Mortality, morbidity, and infarct size at 21 days. N Engl J Med 314:1465–1471

    Article  Google Scholar 

  35. Olsson G, Lubsen J, van Es GA, Rehnqvist N (1986) Quality of life after myocardial infarction; effect of chronic etoprolol treatment on mortality and morbidity. Br Med J 292:1491–1493

    Article  CAS  Google Scholar 

  36. Yates JW, Chalmer B, McKegney FP (1980) Evaluation of patients with advanced cancer using the Karnofsky performance status. Cancer 45:2220–2224

    Article  PubMed  CAS  Google Scholar 

  37. The Multicenter Postinfarction Research Group (1983) Risk stratification after myocardial infarction. N Engl J Med 50:266–272

    Google Scholar 

  38. De Feyter PJ, Van Eenige MG, Dighton DH et al. (1982) Prognostic value of exercise testing, coronary angiography and left ventriculography 6–8 weeks after myocardial infarction. Circulation 66:527–536

    Article  PubMed  Google Scholar 

  39. Fioretti P, Brower RW, Simoons ML et al. (1984) Prediction of mortality in hospital survivors of myocardial infarction. Br Heart J 52:292–298

    Article  PubMed  CAS  Google Scholar 

  40. Kint PP, Simoons ML, Vermeer F, de Graaf S (1986) Early thrombolysis in acute myocardial infarction does not increase CCU workload (abstract). Circulation 74 II:129

    Google Scholar 

  41. Weinstein MC, Stason WB (1982) Cost effectiveness of coronary artery bypass surgery. Circulation 66 III:56–65

    Google Scholar 

  42. ISIS-II (Second International Study of Infarct Survival) (1988) Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-II. Lancet II:349–360

    Google Scholar 

  43. Vermeer F (1987) Thesis: Thrombolysis in acute myocardial infarction. Van Gorkum. Assen Maastricht

    Google Scholar 

Download references

Authors
  1. P. G. Hugenholtz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Cardiology, Lady Davis Carmel Hospital, 34362, Haifa, Israel

    Basil S. Lewis MD (Director) (Director)

  2. University of California, Los Angeles, USA

    Asher Kimchi MD (Assistant Clinical Professor of Medicine, Attending Physician) (Assistant Clinical Professor of Medicine, Attending Physician)

  3. Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA

    Asher Kimchi MD (Assistant Clinical Professor of Medicine, Attending Physician) (Assistant Clinical Professor of Medicine, Attending Physician)

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Hugenholtz, P.G. (1991). Can Thrombolysis Prevent Ischemic Heart Failure?. In: Lewis, B.S., Kimchi, A. (eds) Heart Failure Mechanisms and Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58231-8_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58231-8_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63509-0

  • Online ISBN: 978-3-642-58231-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation