Animal Models Evaluating Platelet-Modifying Drugs

  • L. A. Harker


Acute thrombotic and thromboembolic occlusion of atherosclerotic vessels causes most heart attacks and strokes, and these acute events comprise respectively the first and third leading causes of mortality in the Western world. Thus, the development and testing of effective antithrombotic therapies are important public health strategies. Our understanding of the basic molecular processes involved in the formation and dissolution of thrombus in vitro has expanded rapidly in recent years, and this basic research has led to the development of new and potentially important antithrombotic agents. The evaluation of these new antithrombotic agents requires appropriate and relevant animal models of acute thrombosis. Indeed, the myriad of new antithrombotic pharmacologic agents being developed by peptide synthesis and recombinant DNA technology will be increasingly dependent on testing in vivo to assure their efficacy, safety, and timely application [1]. However, many animal models of thrombosis and thromboembolization have had limited usefulness in the past, particularly where the assessment of vascular occlusion has involved experimental animal species of questionable relevance to man and observations at a single point in time following an initiating vascular insult [2,3]. Additionally, uncontrolled variables may compromise the quantitative aspects of such models. Such uncontrolled factors include the type and extent of the initial vascular injury, loss of thrombus by embolization, loss of thrombus by thrombolysis, hemodynamic characteristics of the model, and the timing and type of observations at death.


Vascular Graft Chloromethyl Ketone Platelet Deposition PTFE Prosthesis Acute Arterial Thrombosis 
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© Springer-Verlag Berlin Heidelberg 1990

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  • L. A. Harker

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