Dietary and Caloric Restriction: Its Effect on Cellular Proliferation in Selected Mouse Tissues

  • D. B. Clayson
  • F. W. Scott
  • R. Mongeau
  • E. A. Nera
  • E. Lok
Conference paper
Part of the ILSI Monographs book series (ILSI MONOGRAPHS)


There is much experimental but very limited clinical evidence that dietary restriction has a beneficial effect in reducing the incidence of naturally occurring and induced cancer formation. Restriction has also been suggested to be advantageous in other respects (Weindruch et al. 1986), including increasing longevity and improving the effectiveness of certain aspects of the immune system. The effect of dietary and caloric restriction on experimental carcinogenesis has been recognized for many years, the sentinel observations being due to Tannenbaum (1940a, 1942; Tannenbaum and Silverstone 1957). Many others have confirmed Tannenbaum’s initial observations (Andreou and Morgan 1981; White 1961; Ross and Bras 1973; Klurfeld et al. 1987). Information on the possible advantageous effect of dietary restriction in humans has proved much more elusive. Although Tannenbaum (1940b) obtained some evidence for a correlation between excessive body weight and cancer from human insurance records, further information has not been adequate to demonstrate this conclusively. In fact, there is a major controversy whether mammary and colonic tumorigenesis in humans is dependent on the high lipid content of the North American diet or on excess calories [National Academy of Sciences (USA) 1980, 1982].


Mammary Gland Calorie Restriction Dietary Restriction Crypt Cell Restricted Diet 
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  1. Andreou KK, Morgan PR (1961) Effect of dietary restriction on induced hamster cheek pouch carcinogenesis. Arch Oral Biol 26: 525–531CrossRefGoogle Scholar
  2. Bieri JG, Stoewgand GS, Briggs GM, Phillips RW, Woodward JC, Knapka JJ (1977) Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J Nutr 107: 1340–1348Google Scholar
  3. Bieri JG (1980) Second report of the ad hoc committee on standards for nutritional studies. J Nutr 110: 1726Google Scholar
  4. Bruce WR, Varghese AJ, Furrer R, Land PC (1977) A mutagen in the feces of normal humans. In: Hiatt HH, Watson JP, Wintsten AJ (eds) Origins of human cancer. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 1641–1646Google Scholar
  5. Craddock VM, Frei JV (1974) Induction of liver cell adenomata in the rat by a single treatment with N-methyl-N-nitrosourea given at various times after partial hepatectomy. Brit J Cancer 30: 503–511PubMedCrossRefGoogle Scholar
  6. Doll R, Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. Oxford University Press, OxfordGoogle Scholar
  7. Gupta I, Baptista J, Bruce WR, Che CT, Furrer R, Gingerich JS, Grey AA, Marai L, Yates P, Krepinsky JJ (1984) Structures of fecaspentaenes, the mutagens of bacterial origin isolated from human feces. Biochemistry 22: 241–245CrossRefGoogle Scholar
  8. Klurfeld DM, Weber MM, Kritchevsky D (1987) Inhibition of chemically induced mammary and colon tumor promotion by calorie restriction in rats fed increased dietary fat. Cancer Res 47: 2769–2762Google Scholar
  9. Lawson TA, Dzhoiev F (1970) The binding of orthoaminoazotoluene to proliferating tissues. Chem Biol Interact 2: 165–174PubMedCrossRefGoogle Scholar
  10. Lok E, Nera EA, Iverson F, Scott F, So Y, Clayson DB (1988) Dietary restriction, cell proliferation and carcinogenesis: a preliminary study. Cancer Lett 38: 249–255PubMedCrossRefGoogle Scholar
  11. Lok E, Scott F, Mongeau R, Nera EA, Malcom S, Clayson DB (1990) Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse. Cancer Lett 51: 67–73PubMedCrossRefGoogle Scholar
  12. Nandi S (1958) Endocrine control of mammary gland development and function in the C3H Crgl mouse. J Natl Cancer Inst 21: 1039–1063PubMedGoogle Scholar
  13. National Academy of Sciences (USA) (1980) Toward healthful diets: report prepared by the Food and Nutrition Board. National Academy of Sciences, Washington, DCGoogle Scholar
  14. National Academy of Sciences (USA) (1982) Diet, nutrition and cancer. Committee on Diet, Nutrition and Cancer, National Research Council, National Academy of Sciences, Washington, DCGoogle Scholar
  15. Nera EA, Lok E, Iverson F, Ormsby E, Karpinski KF, Clayson DB (1984) Short-term pathological and proliferative effects of butylated hydroxyanisole and other phenolic antioxidants in the forestomach of Fischer 344 rats. Toxicology 32: 197–213PubMedCrossRefGoogle Scholar
  16. Ross MH, Bras G (1973) Influence of protein under-and overnutrition on spontaneous tumor prevalence in the rat. J Nutr 103: 944–963PubMedGoogle Scholar
  17. Tannenbaum A (1940a) Initiation and growth of tumors. I. Effect of underfeeding. Am J Cancer 38: 335–350Google Scholar
  18. Tannenbaum A (1940b) Relationship of body weight to cancer incidence. Arch Pathol 30: 509–517Google Scholar
  19. Tannenbaum A (1942) The genesis and growth of tumors. II. Effects of caloric restriction per se. Cancer Res 2: 460–467Google Scholar
  20. Tannenbaum A (1944) The importance of differential consideration of the stages of carcinogenesis in the evaluation of cocarcinogenic and anticarcinogenic effects. Cancer Res 4: 678–677Google Scholar
  21. Tannenbaum A, Silverstone H (1957) Nutrition and the genesis of tumors. In: Raven RW (ed) Cancer. Butterworth, LondonGoogle Scholar
  22. Weindruch R, Walford RL, Fligiel S, Guthrie D (1986) The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr 116: 641–654PubMedGoogle Scholar
  23. Weisburger JH, Jones RC, Wang C-X, Backlund JYC, Williams GM, Kingston Dji, Van Tassel PL, Keyes RF, Wilkins TD, de Wit PP, van der Steeg M, van de Gan A (1990) Carcinogenicity tests of fecapentaene-12 in mice and rats. Cancer Lett 49: 89–98PubMedCrossRefGoogle Scholar
  24. White ES (1961) The relationship between underfeeding and tumor formation, transplantation and growth in rats and mice. Cancer Treat Rev 21: 281–290Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • D. B. Clayson
    • 1
  • F. W. Scott
    • 2
  • R. Mongeau
    • 2
  • E. A. Nera
    • 1
  • E. Lok
    • 1
  1. 1.Toxicology Research Division, Bureau of Chemical Safety, Food DirectorateHealth Protection Branch, Health and Welfare CanadaOttawaCanada
  2. 2.Nutrition Research Division, Bureau of Nutritional Sciences, Food DirectorateHealth Protection Branch, Health and Welfare CanadaOttawaCanada

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