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Dietary and Caloric Restriction: Its Effect on Cellular Proliferation in Selected Mouse Tissues

  • D. B. Clayson
  • F. W. Scott
  • R. Mongeau
  • E. A. Nera
  • E. Lok
Conference paper
Part of the ILSI Monographs book series (ILSI MONOGRAPHS)

Abstract

There is much experimental but very limited clinical evidence that dietary restriction has a beneficial effect in reducing the incidence of naturally occurring and induced cancer formation. Restriction has also been suggested to be advantageous in other respects (Weindruch et al. 1986), including increasing longevity and improving the effectiveness of certain aspects of the immune system. The effect of dietary and caloric restriction on experimental carcinogenesis has been recognized for many years, the sentinel observations being due to Tannenbaum (1940a, 1942; Tannenbaum and Silverstone 1957). Many others have confirmed Tannenbaum’s initial observations (Andreou and Morgan 1981; White 1961; Ross and Bras 1973; Klurfeld et al. 1987). Information on the possible advantageous effect of dietary restriction in humans has proved much more elusive. Although Tannenbaum (1940b) obtained some evidence for a correlation between excessive body weight and cancer from human insurance records, further information has not been adequate to demonstrate this conclusively. In fact, there is a major controversy whether mammary and colonic tumorigenesis in humans is dependent on the high lipid content of the North American diet or on excess calories [National Academy of Sciences (USA) 1980, 1982].

Keywords

Mammary Gland Calorie Restriction Dietary Restriction Crypt Cell Restricted Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • D. B. Clayson
    • 1
  • F. W. Scott
    • 2
  • R. Mongeau
    • 2
  • E. A. Nera
    • 1
  • E. Lok
    • 1
  1. 1.Toxicology Research Division, Bureau of Chemical Safety, Food DirectorateHealth Protection Branch, Health and Welfare CanadaOttawaCanada
  2. 2.Nutrition Research Division, Bureau of Nutritional Sciences, Food DirectorateHealth Protection Branch, Health and Welfare CanadaOttawaCanada

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