Caloric Restriction and Its Effects on Molecular Parameters, Especially DNA Repair

  • A. Turturro
  • R. W. Hart
Part of the ILSI Monographs book series (ILSI MONOGRAPHS)

Abstract

Caloric restriction is a paradigm which inhibits degenerative diseases, chronic induced toxicity, and aging in every species tested (Allaben et al., Chapter 4). An obvious candidate for a mechanism which can be effective in producing such changes in so many diverse biological systems is one that affects a basic biological process involved in disease and toxicity. DNA damage has been postulated to be a common cause or effector for aging, cancer, and a number of degenerative diseases (Turturro et al. 1984). The major modulator of DNA damage is DNA repair, a series of processes which eliminates various kinds of DNA damage, or minimizes the damage to the basic genetic templates (Sancar et al. 1988). Stimulation of DNA repair by caloric restriction, either directly or indirectly, could be responsible for many of the effects seen in caloric restriction.

Keywords

Toxicity Adduct Dine Alan Methylnitrosourea 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • A. Turturro
    • 1
  • R. W. Hart
    • 1
  1. 1.National Center for Toxicological ResearchJeffersonUSA

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