Abstract
Sanguinaria canadensis L. (Fig. 1) is a low perennial with mostly white flowers and thick rhizomes containing an acrid red-orange juice from whence the plant was named (sanguinarius, bleeding). This monotypic genus is a member of the Papaveraceae family, known to contain a diversity of isoquinoline alkaloids, including the protoberberine and benzophenanthridine alkaloids which are found in many species of this family (Berlin et al. 1983). The synonymous Latin binomials for S. canadensis are claimed to be Chelidonium maximum canadense, Sanguinaria acaulis, and Sanguinaria vernalis. Moreover, a number of vernacular names of S. canadensis have been used, some examples include: bloodroot, Indian paint, red root, snakebite, and sweet slumber.
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References
Beecher CWW (1986) The biosynthesis of protoberberine and related alkaloids. Ph.D. thesis, University of Connecticut, pp 92–96
Beecher CWW, Cordell GA (1990) Biosynthesis of Drugs. In: Swarbrick J, Boylan JC (eds) Encyclopedia of pharmaceutical technology. Marcek Dekker, New York, pp 89–116
Beecher CWW, Mahady GB, Schilling AB (1990) The analysis of some isoquinoline alkaloids from cell cultures by particle beam LC/MS. In 38th ASMS Mass Spectrometry and Allied Topics, Tuscon, USA, pp 1087–1088
Berlin J, Forche E, Wray V, Hammer J, Hosel W (1983) Formation of benzophenanthridine alkaloids by suspension cultures of Eschscholtzia californica. Z Naturforsch 38c:346–352
Caolo MA, Stermitz FR (1979) Benzophenanthridinium salt equilibria. Heterocycles 12:11–14
Cordell GA, Farnsworth NR (1976) A review of selected potential anticancer plant principles. Heterocycles 4:393–427
Cordell GA, Farnsworth NF (1977) Experimental antitumor agents from plants, 1974–1976. Lloydia 40:1–44
Dana JF (1827) An account of some experiments on the root of Sanguinaria canadensis. NY Med Phys J 6:218–224
Dzink JL, Socransky SS (1985) Comparative in vitro activity of sanguinarine against oral microbial isolates. Antimicrob Agents Chemother 27:663–665
Foster S, Duke JA (eds) (1990) A field guide to medicinal plants. Houghton Mifflin Boston
Gamborg OL, Miller RA, Ojima K (1968) Nutrient requirements of suspension cultures of soybean root cells. Exp Cell Res 50:151–158
Godowski KC (1980) Antimicrobial action of sanguinarine. J Clin Dent 1:96–101
Hartwell JL (1960) Plant remedies for cancer. Cancer Chemother Rep 7:19–29
Hashimoto Y, Okada MI, Shome U, Kato A (1986) The analysis of some papaveraceous plants by newly devised automated histochemical chromatography. Anal Lett 19:2253–2260
Knobloch KH (1982) Uptake of phosphate and its effect on phenylalanine ammonialyase activity and cinnamoyl putrescine accuniulation in cell suspension cultures of Nicotiana tabacum. Plant Cell Rep 1:128–130
Knobloch KH, Berlin J (1983) Influence of phosphate on the formation of indole alkaloids and phenolic compounds in cell suspension cultures of Catharanthus roseus. Plant Cell Tissue Organ Cult 21:333–340
Krane BD, Fagbule MO, Shamma M (1984) The benzophenanthridine alkaloids. J Nat Prod 47:1–43
Lindsey K, Yeoman MM (1983) The relationship between growth rate, differentiation and alkaloid accumulation in cell cultures. J Exp Bot 34:1055–1065
Mahady GB (1991) The regulation of benzophenanthridine alkaloid biosynthesis in suspension cultures of Sanguinaria canadensis. Ph.D. thesis, University of Illinois, pp 47–81
Mahady GB, Beecher CWW (1990a) The estimation of macromolecular biosynthesis in plant cells. Phytochem Anal 1:60–62
Mahady GB, Beecher CWW (1990b) Retinoid stimulation of benzophenanthridine alkaloid biosynthesis. Plant Physiol 93:21
Mahady GB and Beecher CWW (1990c) Use of Amicon Centriprep-10 concentrators in the synthesis of intermediates for biosynthetic studies in Sanguinaria canadensis callus cultures. Lab News, Amicon, 954:1–8
Mahady GB, Beecher CWW (1991a) A bioassay system for screening compounds as potential elicitors. Plant Physiol 96:605
Mahady GB, Beecher CWW (1991b) The role of CAMP in secondary metabolite induction. Plant Physiol 96:988
Mahady GB, Beecher CWW (1991c) The role of calcium in the induction of secondary metabolism. In International Research Congress on Natural Products, Chicago, IL, 20 pp
Niering WA, Olmstead NC (eds) (1988) The Audubon Society field guide to North American wildflowers. AA Knopf, New York
Phillips R, Henshaw GG (1977) The regulation of synthesis of phenolics in stationary phase cell cultures of Acer pseudoplatanus. J Exp Bot 28:785–794
Rueffer M, Zenk MH (1986) S-Adenosyl-L-methionine: (s)-7,8,13,14-tetrahydroberbine-cis-N-methyltransferase, a branch point enzyme in the biosynthesis of benzophenanthridine and protopine alkaloids. Tetrahedron Lett 27:5603–5607
Schenck G, Hanse H (1954) The separation of sanguinarine and chelerythrine and associated discovery of new alkaloids from Sanguinaria canadensis. Arch Pharm 277:355
Sethi VS, Sethi ML (1975) Inhibition of reverse transcriptase activity of RNA-tumor viruses by fagonine. Biochem Biophys Res Commun 63:1070–1076
Simanek V (1985) Benzophenanthridine alkaloids. In: Manske RHF (ed) The alkaloids. vol. 26, Academic Press, New York, pp 186–240
Slavik J, Slavikova L (1960) Alkaloide der Mohngewachse (Papaveraceae) XVII. Uber neue Alkaloide aus Sanguinaria canadensis L. Collect Czech Chem Commun 25:1667
Straub KD, Carver P (1975) Sanguinarine, inhibitor of Na-K dependent ATP’ase Biochem Biophys Res Commun 62:913–921
Tin-Wa M, Farnsworth NR, Fong HHS, Trojanek J (1970) Biological and phytochemical evaluation of plants VIII. Isolation of a new alkaloid from Sanguinaria canadensis. Lloydia 33:267–269
Willaman JJ, Schubert BG (1961) Alkaloid-bearing plants and their contained alkaloids. Tech Bull 1234, ARS, US. Dept Agdc, Washington, D.C., 174 pp
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© 1993 Springer-Verlag Berlin Heidelberg
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Mahady, G.B., Schilling, A.B., Beecher, C.W.W. (1993). Sanguinaria canadensis L. (Sanguinarius): In Vitro Culture and the Production of Benzophenanthridine Alkaloids. In: Bajaj, Y.P.S. (eds) Medicinal and Aromatic Plants V. Biotechnology in Agriculture and Forestry, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58062-8_22
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DOI: https://doi.org/10.1007/978-3-642-58062-8_22
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