Cytokine release regarding different perfusion systems and its effect on S100B protein levels
During cardiopulmonary bypass (CPB), blood is exposed to foreign surfaces and abnormal sheer forces. These abnormal conditions lead to an activation of coagulation (9), fibrinolysis (9), the complement pathway (2) and of the cellular and humoral immune system (15), finally resulting in a general inflammatory reaction. Clinically, this so-called “post pump response” is linked to myocardial dysfunction, respiratory distress, renal failure, and neurological deficits. All these clinical aspects are mostly consequences of endothelial injury and increased vascular permeability — at least partly caused by the release of cytokines, which are known to mediate vascular injury and organ dysfunction (4, 14).
KeywordsPermeability Ischemia Recombinated Heparin Thrombin
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