Skip to main content
SpringerLink
Log in

Die Behandlung von Knorpeldefekten mit implantierten autologen Chondrozyten in Kombination mit einer Periostlappentransplantation

  • Chapter
Book cover Gelenkknorpeldefekte

  • 54 Accesses

Zusammenfassung

Weltweit haben Wissenschaftler primitive, chondrogene Zellen zur Behandlung von Knorpeldefekten einzusetzen. Solche Zellen sind zum Beispiel im Knochenmark enthalten und werden durch Eröffnung des subchondralen Raumes freigesetzt [22,37]. Auch in Perichondrium oder Periostium werden solche Zellen vermutet und werden klinisch genutzt [21,34]. Diese Art der so genannten biologischen Neubeschichtung war vielversprechend in Versuchen mit adoleszenten Tieren, ist jedoch noch nicht ausreichend erforscht in menschlichen Patienten.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Angermann P, Riegels-Nielsen P (1994) Osteochondritis Dissecans of the femoral condyle treated with periosteal transplantation. A preliminary clinical study of 14 patients. Orthopaedics 2:425–428

    Google Scholar 

  2. Angermann P, Riegels-Nielsen P, Pedersen H (1998) Osteochondritis Dissecans of the femoral condyle treated with periosteal transplantation. Poor outcome in 14 patients followed for 6–9 years. Acta Orthop Scand 69(6):595–597

    Article  PubMed  CAS  Google Scholar 

  3. Bahuaud J, Maitrot RC, Bouvet R, Kerdiles N, Tovagliaro F, Synave J, Buisson P, Thierry JF, Versier A, Romanet JP, Chauvin F, Gilet JP, Allizard JP, de Belenet H (1998) Implantation of autologous chondrocytes for cartilaginous lesions in young patients. A study of 24 cases. Chirurgie 123(6):568–571 [Article in French]

    Article  PubMed  CAS  Google Scholar 

  4. Benya PD, Schaffer JD (1982) Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30:215–224

    Article  PubMed  CAS  Google Scholar 

  5. Behrens P, Fuß M, Köchermann K-U, Russlies M, Plötz W (1999) Matrix-induzierte autogene Chondrozytentransplantation zur Behandlung von Knorpeldefekten. Osteologie 1999, Band 8, Supplement III-Abstract-Texte Norddeutschen Ortopädenvereinigung e.V. 1719, pp 22–23

    Google Scholar 

  6. Brittberg M (1996) Cartilage repair. On cartilaginous tissue engineering with the emphasis on chondrocyte transplantation. PhD thesis, Göteborg University, Göteborg

    Google Scholar 

  7. Brittberg M, Nilsson A, Lindahl A, Ohlsson C, Peterson L (1996) Rabbit articular cartilage defects in the knee with autologous cultured chondrocytes. Clin Orthop Rel Res 326:270–283

    Article  Google Scholar 

  8. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. New England Journal of Medicine 331:889–895

    Article  PubMed  CAS  Google Scholar 

  9. Brower TD, Akahoshi Y, Orlic P (1964) Diffusion of dyes through articular cartilage in vivo. J Bone Joint Surg 44A:456–463

    Article  CAS  Google Scholar 

  10. Buckwalter JA, Cruess R (1991) Healing of musculoskeletal tissues. In: Rockwood CA, Green DP, Bucholtz RW (Eds) Fractures in adults (3rd). Lippincott, Philadelphia, pp 181–222

    Google Scholar 

  11. Bujia J, Meyer H, Kim C, Hammer C, Wilmes E, Gurtler L (1993) In vitro studies of possible transmission of human immunodeficiency virus (HIV) by allogeneic cartilage transplants. Laryngorhinootologie 72(10):473–477

    Article  PubMed  CAS  Google Scholar 

  12. Burkart A, Imhoff A (1998) Erste Ergebnisse nach autologer chondrozytenimplantation unter Berücksichtigung kernspintomographischer under histologischer Befunde. In: Imhoff AB, Burkart A (Eds) Knieinstabilität-Knorpelschaden. Steinkopff, Darmstadt, pp 75–81

    Chapter  Google Scholar 

  13. Byers PD, Conteponti CA, Farkas TA (1970) A post-mortem study of the hip-joint. Ann Rheum Dis 29:15–31

    Article  PubMed  CAS  Google Scholar 

  14. Davis MA (1988) Epidemiology of osteoarthritis. Clin Geriatric Med 4:241–255

    CAS  Google Scholar 

  15. Doherty PJ, Zhang H, Tremblay L, Manolopoulos V, Marshall KW (1998) Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro. Osteoarthritis Cartilage 6(3):153–159

    Article  PubMed  CAS  Google Scholar 

  16. Gillogly SD (1998) Autologous chondrocyte implantation: Current state-of-the-art. In: Imhoff AB, Burkart A (Eds) Knieinstabilität-Knorpelschaden. Steinkopff, Darmstadt, 60–66

    Chapter  Google Scholar 

  17. Gillogly SD, Voight M, Blackburn T (1998) Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation. J Orthop Sports Phys Ther 28(4):241–251

    PubMed  CAS  Google Scholar 

  18. Grande DA, Pitman MI, Peterson L, Menche D, Klein M (1989) The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantation. J Orthop Res 7:208–218

    Article  PubMed  CAS  Google Scholar 

  19. Hjelle K, Austgulen 0, Muri R, Rokstad K, Strand T, Solheim E (1999) Funn av fokale leddbruskskader ved 800 kneartroskopier. Vitenskaplige forhandlinger. Den Norske Kirurgiske foreningens Arsmöte, Oslo 25–29. 10. 1999. Ed H Hofgaard, Oslo 1999:246 (in Norwegian)

    Google Scholar 

  20. Hjertquist SO, Lemperg R (1971) Histologic audiographic and micro-chemical studies with spontaneously healing osteochondral articular defects in adult rabbits. Calcif Tissue Res 8:54–72

    Article  PubMed  CAS  Google Scholar 

  21. Homminga G, Bulstra SK, Bouwmeester PSM, van der Linden AJ (1990) Perichondral grafting for cartilage lesions of the knee. J Bone Joint Surg 72B:1003–1007

    Google Scholar 

  22. Insall J (1974) The Pridie debridement operation for osteoarthritis of the knee joint. Clin Orthop 101:61–67

    Google Scholar 

  23. Kawabe N, Yoshinao M (1991) The repair of full thickness articular cartilage defects. Immune responses to reparative tissue formed by allogeneic growth plate chondrocyte implants. Clin Orthop 268:279–293

    Google Scholar 

  24. Knutsen G, Solheim E, Johansen O (1998) Behandling av fokale leddbruskskader i kne. Tidsskrift Nor Laegeforen 118:2493–2497 (in Norwegian)

    Google Scholar 

  25. Labs K, Perka C (1999) Schädigungsmuster traumatischer und degenerativer Knorpelschäden des Kniegelenkes. Osteologie 1999, Band 8, Supplement III-Abstract-Texte Norddeutschen Orthopädenvereinigung e.V. 17–19, p 24

    Google Scholar 

  26. Lohnert J (1998) Regeneration of hyalin cartilage in the knee joint by treatment with autologous chondrocyte transplants - initial clinical results. Langenbecks Arch Chir Suppl Kongressbd 115:1205–1207

    PubMed  CAS  Google Scholar 

  27. Mandelbaum BR, Browne JE, Fu F, Micheli L, Mosely JB, Erggelet C, Minas T, Peterson L (1998) Articular cartilage lesions of the knee. Current concepts. Am J Sports Med 26:853–861

    PubMed  CAS  Google Scholar 

  28. Manolopoulos V, Wayne Marshall K, Zhang H, Trogadis J, Tremblay L, Hoherty PJ (1999) Factors affecting the efficacy of bovine chondrocyte transplantation in vitro. 7:453–460

    CAS  Google Scholar 

  29. Minas T (1998) Chondrocyte implantation in the repair of chondral lesions of the knee: economics and quality of life. Am J Orthop 27(11):739–744

    PubMed  CAS  Google Scholar 

  30. Minas T (1999) The role of cartilage repair techniques, including chondrocyte transplantation, in focal chondral knee damage. Instr Course Lect 48:629–643

    PubMed  CAS  Google Scholar 

  31. Mont MA, Jones LC, Vogelstein BN, Hungerford DS (1999) Evidence of inappropriate application of autologous chondrocyte transplantation therapy in an uncontrolled environment. Am J Sports Med 27:617–620

    PubMed  CAS  Google Scholar 

  32. Noguchi T, Oka M, Fujino M, Neo M, Yamamuro T (1994) Repair of osteochondral defects with grafts of cultured chondrocytes. Comparison of allografts and isografts. Clin Orthop 302:251–258

    PubMed  Google Scholar 

  33. O’Driscoll SW, Keeley FW (1988) Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full thickness defects in joint surfaces under the influence of continous passive motion. J Bone Joint Surg 70A:595–606

    Google Scholar 

  34. O’Driscoll SW, Salter RB (1984) The induction of neochondrogenesis in free intraarticular periosteal autografts under the influence of continous passive motion. J Bone Joint Surg 66A:1248–1257

    Google Scholar 

  35. O’Driscoll SW, Fitzgibbons JS, Commisso CN (1997) Role of oxygen tension during cartilage formation by periosteum. J Orthop Res 15:682–687

    Article  PubMed  Google Scholar 

  36. Peterson L, Menche D, Grande D et al. (1984) Chondrocyte transplantation - an experimental model in the rabbit. Trans Orthop Res Soc 9:218

    Google Scholar 

  37. Pridie KH (1959) A method of resurfacing osteoarthritic knee joints. J Bone Joint Surg 41B:618–619

    Google Scholar 

  38. Radin E (1990) Factors influencing osteoarthrosis progression. In: Whit Ewing J (Ed) Articular cartilage and knee joint function. Basic science and arthroscopy. Raven Press, pp 301–309

    Google Scholar 

  39. Rasanen T, Messner K (1996) Regional variations of indentation stiffness and thickness of normal rabbit knee articular cartilage. J Biomed Mater Res 31:519–524

    Article  PubMed  CAS  Google Scholar 

  40. Schatzker J (1987) Intra-articular fractures. In: Schatzker J, Tile M (Eds) Rationale of operative fracture care. Springer, Berlin, pp 13–21

    Google Scholar 

  41. Schinagl RM, Kurtis MS, Ellis KD, Chien S, Sah RL (1999) Effect of seeding duration on the strength of chondrocyte adhesion to articular cartilage. J Orthop Res 17:121–129

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. M. Brittberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Orthopädische Universitätsklinik, Hugstetter Str. 55, Freiburg, D-79106, Germany

    Christoph Erggelet  & Matthias Steinwachs  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Brittberg, M. (2001). Die Behandlung von Knorpeldefekten mit implantierten autologen Chondrozyten in Kombination mit einer Periostlappentransplantation. In: Erggelet, C., Steinwachs, M. (eds) Gelenkknorpeldefekte. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57716-1_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57716-1_12

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-7985-1265-8

  • Online ISBN: 978-3-642-57716-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation