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Adenovirus-mediated myocardial gene therapy

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Molecular Approaches to Heart Failure Therapy

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Abstract

The introduction of genetic material to the heart showed promise when adenovirus vectors were demonstrated to easily and efficiently transfer reporter genes to isolated cardiac myocytes in vitro [17, 18]. Numerous possibilities for the new technology were readily apparent. The most obvious was the replacement of genetic defects in inherited disorders, such as the long QT syndrome and several types of hypertrophic and dilated cardiomyopathies. Even more exciting, however, was the prospect of using this technology to modify more common, acquired diseases including ischemic diseases, acquired cardiomyopathies and arrhythmias. Most of these diseases affect every cell in the heart, so therapeutic applications would require delivery of the gene of interest to a majority of the myocytes in a homogeneous pattern throughout the heart.

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Authors and Affiliations

  1. Institute of Molecular Cardiobiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    J. K. Donahue

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  1. J. K. Donahue
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Editors and Affiliations

  1. Zentrum Innere Medizin, Abt. Kardiologie und Pneumologie, Georg-August-Universität Göttingen, Robert-Koch-Straße 40, Göttingen, D-37075, Germany

    Gerd Hasenfuss

  2. Section of Molecular and Cellular Cardiology, The Johns Hopkins University, 844 Ross Building, Baltimore, MD, 21205, USA

    Eduardo Marbán M.D., Ph.D. (Professor of Medicine and Physiology) (Professor of Medicine and Physiology)

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© 2000 Springer-Verlag Berlin Heidelberg

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Donahue, J.K. (2000). Adenovirus-mediated myocardial gene therapy. In: Hasenfuss, G., Marbán, E. (eds) Molecular Approaches to Heart Failure Therapy. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57710-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-57710-9_9

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63332-4

  • Online ISBN: 978-3-642-57710-9

  • eBook Packages: Springer Book Archive

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