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Manipulation of SERCA2a in the heart by gene transfer

  • F. Del Monte
  • S. E. Harding
  • R. J. Hajjar

Abstract

In the myopathic heart, a number of abnormalities have been delineated (Fig. 1) at the cellular level [25-33, 35, 38-43]. These include changes at the level of the sarcolemma, sarcoplasmic reticulum, myofilaments, and mitochondria, all of which contribute to depressed contractile function and reserve [25-33, 35, 38-43]. Identifying the mechanisms by which these changes contribute to the observed pathology is frequently confounded by simultaneous alterations in multiple signaling pathways in the complex milieu of the failing heart. Targeting genes to the heart through somatic gene transfer allows us to identify and characterize the molecular changes of diseases as well as to manipulate the targeted pathways [34, 36, 37].

Keywords

Gene Transfer Sarcoplasmic Reticulum Ryanodine Receptor Calcium Handling Human Heart Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • F. Del Monte
    • 1
  • S. E. Harding
    • 2
  • R. J. Hajjar
    • 1
  1. 1.Program in Cardiovascular Gene Therapy, Cardiovascular Research CenterMassachusetts General HospitalBostonUSA
  2. 2.Cardiac Medicine, National Heart Lung InstituteImperial College of MedicineLondonUK

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