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Cardiac assistance from skeletal muscle achieving a viable and appropriately transformed graft

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Surgical Remodeling in Heart Failure

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Abstract

For some years the surgical treatment of end-stage cardiac failure has been restricted to cardiac transplantation. The discovery that adult mammalian skeletal muscle is capable of undergoing adaptive change, through which it can acquire a markedly increased resistance to fatigue, has revived interest in the possibility of diverting a skeletal muscle from its normal function to perform in a cardiac assist role. For procedures based on this approach to be successful, the skeletal muscle graft must remain viable and acquire a functional profile appropriate to the task. Recent work shows that we have a better chance of achieving these objectives if we re-examine both the working conditions and the way in which we prepare the skeletal muscle graft to meet them.

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  1. Professor Stanley Salmons Department of Human Anatomy and Cell Biology New Medical School, Ashton Street University of Liverpool Liverpool L69 3GE, U.K

    S. Salmons

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  1. Universitätsklinik für Herz- und Thoraxchirurgie, Kantonsspital Basel, Spitalstraße 21, Basel, CH-4031

    W. Brett , A. Todorov , M. Pfisterer  & Hans-Reinhard Zerkowski , ,  & 

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Salmons, S. (2000). Cardiac assistance from skeletal muscle achieving a viable and appropriately transformed graft. In: Brett, W., Todorov, A., Pfisterer, M., Zerkowski, HR. (eds) Surgical Remodeling in Heart Failure. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57705-5_4

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  • DOI: https://doi.org/10.1007/978-3-642-57705-5_4

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-7985-1223-8

  • Online ISBN: 978-3-642-57705-5

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