Skip to main content
SpringerLink
Log in

Lung cancer

  • Chapter
PET in Clinical Oncology

Abstract

Lung cancer is one of the most prevalent cancers in the world and a leading cause of cancer death both in men and women. Thus, it is a major health problem with 180 000 new cases in the United States in 1996. Men are five times more affected than women due to the different smoking habits [29, 42]. In men 90% and in women 30-60% of all lung cancers are attributed to cigarette smoking. The proportion of smoking women is continuously increasing; thus, in the United States lung cancer has surpassed breast carcinoma as the leading cause of cancer death in women in the late 1980s [29]. Small cell lung cancer (SCLC) is the most rapidly increasing cell type in women [42]. Occupational exposure to carcinogens also has a role although smaller in carcinoma induction. There is no significant correlation between lung cancer and residential radon nor air pollution exposure [29, 42].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ahuja V, Coleman RE, Herndon J, Patz EF (1998) The prognostic significance of fluorodeoxyglucose positron emission tomography imaging for patients with non-small cell lung carcinoma. Cancer 83:918–924

    Article  PubMed  CAS  Google Scholar 

  2. Al-Sugair A, Coleman RE (1998) Applications of PET in lung cancer. Sem Nucl Med 28:303–319

    Article  CAS  Google Scholar 

  3. Austin JHM, Cohen MB (1993) Value of having a cytopathologist present during per-cutaneous fine-needle biopsy of lung: report of 55 cancer patients and metaanalysis of the literature. Chest 160:175–177

    CAS  Google Scholar 

  4. Boland GW, Goldberg MA, Lee MJ, Mayo-Smith WW, Dixon J, McNicholas MM, Mueller PR (1995) Indeterminate adrenal mass in patients with cancer: evaluation at PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology 194:131–134

    PubMed  CAS  Google Scholar 

  5. Brudin LH, Valind SO, Rhodes CG, Pantin CF, Sweatman M, Jones T, Hughes JMB (1994) Fluorine-18 deoxyglucose uptake in sarcoidosis measured with positron emission tomography. Eur J Nucl Med 21:297–305

    Article  PubMed  CAS  Google Scholar 

  6. Budinger T (1998) PET instrumentation: what are the limits? Sem Nucl Med 28:247–267

    Article  CAS  Google Scholar 

  7. Bury T, Barreto A, Daenen F, Barthelemy N, Ghaye B, Rigo P (1998) Fluorine-18 deoxyglucose positron emission tomography for the detection of bone metastases in patients with non-small cell lung cancer. Eur J Nucl Med 25:1244–1247

    Article  PubMed  CAS  Google Scholar 

  8. Bury T, Dowlati A, Paulus P, Hustinx R, Radermecker M, Rigo P (1996) Staging of non-small-cell lung cancer by whole-body fluorine-18 deoxyglucose positron emission tomography. Eur J Nucl Med 23:204–206

    Article  PubMed  CAS  Google Scholar 

  9. Chin R, Ward R, Keyes JW, Choplin RH, Reed JC, Wallenhaupt S, Hudspeth AS, Haponik EF (1995) Mediastinal staging of non-small-cell lung cancer with positron emission tomography. Am J Respir Crit Care Med 152:2090–2096

    PubMed  Google Scholar 

  10. Chiti A, Schreiner FAG, Crippa F, Pauwels EKJ, Bombardieri E (1999) Nuclear medicine procedures in lung cancer. Eur J Nucl Med 26:533–555

    Article  PubMed  CAS  Google Scholar 

  11. Coleman RE (1999) PET in lung cancer. J Nucl Med 40:814–820

    PubMed  CAS  Google Scholar 

  12. Conces DJ, Tarver RD, Gray WC, Pearcy EA (1988) Treatment of pneumothoraces utilizing small caliber chest tubes. Chest 94:55–57

    Article  PubMed  Google Scholar 

  13. Dewan NA, Gupta NC, Redepenning LS, Phalen JJ, Frick MP (1993) Diagnostic efficacy of FDG-PET imaging in solitary pulmonary nodules. Chest 104:997–1002

    Article  PubMed  CAS  Google Scholar 

  14. Dewan NA, Reeb SD, Gupta NC, Gobar LS, Scott WJ (1995) PET-FDG imaging and transthoracic needle lung aspiration biopsy in evaluation of pulmonary lesions. Chest 108:441–446

    Article  PubMed  CAS  Google Scholar 

  15. Dewan NA, Shehan CJ, Reeb SD, Gobar LS, Scott WJ, Ryschon K (1997) Likelihood of malignancy in a solitary pulmonary nodule. Comparison of Bayesian analysis and results of FDG-PET scan. Chest 112:416–422

    Article  PubMed  CAS  Google Scholar 

  16. Donhuijsen K (1998) Histologisches Malignitätsgrading. Dt Ärztebl 95:2391–2395

    Google Scholar 

  17. Duhaylongsod FG, Lowe VJ, Patz EF, Vaughn AL, Coleman RE, Wolfe WG (1995) Lung tumor growth correlates with glucose metabolism measured by fluoride-18 fluorodeoxyglucose positron emission tomography. Ann Thorac Surg 60:1348–1350

    Article  PubMed  CAS  Google Scholar 

  18. Duhaylongsod FG, Lowe VJ, Patz EF, Vaughn AL, Coleman RE, Wolfe WG (1995) Detection of primary and recurrent lung cancer by means of F-18 fluorodeoxyglucose positron emission tomography (FDG PET). J Thorac Cardiovasc Surg 110:130–140

    Article  PubMed  CAS  Google Scholar 

  19. Dunninck NR (1990) Adrenal imaging: current status. AJR 154:927–936

    Google Scholar 

  20. Erasmus JJ, McAdams HP, Patz EF, Coleman RE, Ahuja V, Goodman PC (1998) Evaluation of primary pulmonary carcinoid tumors using FDG PET. AJR 170:1369–1373

    PubMed  CAS  Google Scholar 

  21. Fischman AJ, Alpert NM (1993) FDG-PET in oncology: there’s more to it than looking at pictures. J Nucl Med 34:6–10

    PubMed  CAS  Google Scholar 

  22. Flier JS, Mueckler M, Usher P, Lodish HF (1987) Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 235:1492–1495

    Article  PubMed  CAS  Google Scholar 

  23. Fontana RS, Sanderson DR, Woolner LW, Taylor WT, Miller WE, Muhm JR, Bernatz PE, Payne WS, Pairolero PC, Bergstralh EJ (1991) Screening for lung cancer - a critique of the Mayo lung project. Cancer 67:1155–1164

    Article  PubMed  CAS  Google Scholar 

  24. Frank A, Lefkowitz D, Jaeger S, Gobar L, Sunderland J, Gupta N, Scott W, Mailliard J, Lynch H, Bishop J, Thorpe P, Dewan N (1995) Decision logic for the treatment of asymptomatic lung cancer recurrence based on positron emission tomography findings. Int J Radiation Oncology Biol Phys 32:1495–1512

    Article  CAS  Google Scholar 

  25. Fujiwara T, Matsuzawa T, Kubota K, Abe Y, Itoh M, Fukuda H, Hatazawa J, Yoshioka S, Yamaguchi K, Ito K, Watanuki S, Takahasi T, Ishiwata K, Iwata R, Ido T (1989) Relationship between histologic type of primary lung cancer and carbon-ll-L-methionine uptake with positron emission tomography. J Nucl Med 30:33–37

    PubMed  CAS  Google Scholar 

  26. Gallagher BM, Fowler JS, Gutterson NI, MacGregor RR, Wan CN, Wolf AP (1978) Metabolic trapping as aprinciple of radiopharmaceutical design: some factors responsible for the biodistribution of [18F] 2-deoxy-2-fluoro-D-glucose. J Nucl Med 19:1154–1161

    PubMed  CAS  Google Scholar 

  27. Gambhir SS, Hoh CK, Phelps ME, Madar I, Maddahi J (1996) Decision tree sensitivity analysis for cost-effectiveness of FDG-PET in the staging and management of nonsmall-cell lung carcinoma. J Nucl Med 37:1428–1436

    PubMed  CAS  Google Scholar 

  28. Gambhir SS, Shepherd JE, Shah BD, Hart CK, Valk PE, Emi T, Phelps ME (1998) Analytical decision model for the cost-effectiveness management of solitary pulmonary nodules. J Clin Oncol 16:2113–2125

    PubMed  CAS  Google Scholar 

  29. Ginsberg RJ, Vokes EE, Raben A (1997) Non-small cell lung cancer. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer: Principles and Practice of Oncology. Lippincott-Raven, Philadelphia, pp 858–911

    Google Scholar 

  30. Glazer GM, Gross BH, Quint LE, Francis IR, Bookstein FL, Orringer MB (1985) Normal mediastinal lymph nodes: number and size according to American Thoracic Society mapping. AJR 144:261–265

    PubMed  CAS  Google Scholar 

  31. Glazer HS, Lee JKT, Levitt RG, Heiken JP, Ling D, Totty WG, Balfe DM, Emani B, Wasserman TH, Murphy WA (1985) Radiation fibrosis: differentiation from recurrent tumor by MR - work in progress. Radiology 156:721–726

    PubMed  CAS  Google Scholar 

  32. Gross BH, Glazer GM, Orringer MB, Spizarny DL, Flint A (1988) Bronchogenic carcinoma metastatic to normal-sized lymph nodes: frequency and significance. Radiology 166:71–74

    PubMed  CAS  Google Scholar 

  33. Gupta NC, Frank AR, Dewan NA, Redepenning LS, Rothberg ML, Mailliard JA, Phalen JJ, Sunderland JJ, Frick MP (1992) Solitary pulmonary nodules: detection of malignancy with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology 184:441–444

    PubMed  CAS  Google Scholar 

  34. Gupta NC, Maloof J, Gunel E (1996) Probability of malignancy in solitary pulmonary nodules using fluorine-18-FDG and PET. J Nucl Med 37:943–948

    PubMed  CAS  Google Scholar 

  35. Hamberg LM, Hunter GJ, Alpert NM, Choi NC, Babich JW, Fischman AJ (1994) The Dose Uptake Ratio as an index of glucose metabolism: useful parameter or oversimplification? J Nucl Med 35:1308–1312

    PubMed  CAS  Google Scholar 

  36. Haramati LB, Austin JHM (1991) Complications after CT-guided needle biopsy through aerated versus nonaerated lung. Radiology 181:778

    PubMed  CAS  Google Scholar 

  37. Hellwig A, Hellwig D, Ukena D, Sybrecht GW, Kirsch CM (1998) FDG-PET zur Differenzierung zwischen benignen and malignen Pleuraergüssen. Nuklearmedizin 37:A70 (abstr)

    Google Scholar 

  38. Higashi K, Ueda Y, Seki H, Yuasa K, Oguchi M, Noguchi T, Taniguchi M, Tonami H, Okimura T, Yamamoto I (1998) Fluorine-18-FDG PET imaging is negative in bronchioloalveolar lung carcinoma. J Nucl Med 39:1016–1020

    PubMed  CAS  Google Scholar 

  39. Hoffman EJ, Huang SC, Phelps ME (1979) Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr 3:299–308

    Article  PubMed  CAS  Google Scholar 

  40. Hübner KF, Buonocore E, Singh SK, Gould HR, Cotten DW (1995) Characterization of chest masses by FDG positron emission tomography. Clin Nucl Med 20:293–298

    Article  PubMed  Google Scholar 

  41. Ichiya Y, Kuwabara Y, Sasaki M, Yoshida T, Omagari J, Akashi Y, Kawashima A, Fukumura T, Masuda K (1996) A clinical evaluation of FDG-PET to assess the response in radiation therapy for bronchogenic carcinoma. Ann Nucl Med 10:193–200

    Article  PubMed  CAS  Google Scholar 

  42. Ihde DC, Pass HI, Glatstein E (1997) Small cell lung cancer. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer: Principles and Practice of Oncology. Lippincott-Raven, Philadelphia, pp 911–949

    Google Scholar 

  43. Inoue T, Kim EE, Komaki R, Wong FCL, Bassa P, Wong WH, Yang DJ, Endo K, Podoloff DA (1995) Detecting recurrent or residual lung cancer with FDG-PET. J Nucl Med 36:788–793

    PubMed  CAS  Google Scholar 

  44. Kazerooni EA, Lim FT, Mikhail A, Martinez FJ (1996) Risk of pneumothorax in CT-guided transthoracic needle aspiration biopsy of the lung. Radiology 198:371–375

    PubMed  CAS  Google Scholar 

  45. Khouri NF, Meziane MA, Zerhouni EA, Fishman EK, Siegelman SS (1987) The solitary pulmonary nodule - assessment, diagnosis, and management. Chest 91:128–133

    Article  PubMed  CAS  Google Scholar 

  46. Kim CK, Gupta NC, Chandramouli B, Alavi A (1994) Standardized uptake value of FDG: body surface area correction is preferable to body weight correction. J Nucl Med 35:164–167

    PubMed  CAS  Google Scholar 

  47. Kim BT, Kim Y, Lee KS, Yoon SB, Cheon EM, Kwon OJ, Rhee JH, Han J, Shin MH (1998) Localized form of bronchioloalveolar carcinoma: FDG PET findings. AJR 170:935–939

    PubMed  CAS  Google Scholar 

  48. Knopp MV, Bischoff HG (1994) Beurteilung von pulmonalen Herden mit der Positronenemissionstomographie. Radiologe 34:588–591

    PubMed  CAS  Google Scholar 

  49. Knopp MV, Bischoff H, Rimac A, Doll J, Oberdorfer F, Lorenz WI, van Kaick G (1994) Clinical utility of positron emission tomography with FDG for chemotherapy response monitoring - a correlative study of patients with small cell lung cancer. J Nucl Med 35:75P (abstr)

    Google Scholar 

  50. Knopp MV, Strauss LG, Haberkorn U et al. (1990) Positron emission tomography (PET) with 18F-deoxyglucose in the imaging and staging of bronchogenic carcinoma. Eur J Nucl Med 16:560

    Google Scholar 

  51. Koh WJ, Bergman KS, Rasey JS, Peterson LM, Evans ML, Graham MM, Grierson JR, Lindsley KL, Lewellen TK, Krohn KA, Griffin TW (1995) Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography. Int J Radiat Oncol Biol Phys 33:391–398

    Article  PubMed  CAS  Google Scholar 

  52. Kubota K, Matsuwaza T, Fujiwara T, Ito M, Hatazawa J, Ishiwata K, Iwata R, Ido T (1990) Differential diagnosis of lung tumor with positron emission tomography: a prospective study. J Nucl Med 31:1927–1933

    PubMed  CAS  Google Scholar 

  53. Kubota K, Matsuzawa T, Masatoshi I, Ito K, Fujiwara T, Abe Y, Yoshioka S, Fukuda H, Hatazawa J, Iwata R, Watanuki S, Ido T (1985) Lung tumor imaging by positron emission tomography using C-11-Methionine. J Nucl Med 26:37–42

    PubMed  CAS  Google Scholar 

  54. Kubota K, Yamada S, Ishiwata K, Ito M, Ido T (1992) Positron emission tomography for treatment evaluation and recurrence detection compared with CT in long-term follow-up cases of lung cancer. Clin Nucl Med 17:877–881

    Article  PubMed  CAS  Google Scholar 

  55. Langen KJ, Braun U, Rota-Kops E, Herzog H, Kuwert T, Nebeling B, Feinendegen LE (1993) The influence of plasma glucose levels on fluorine-18-fluorodeoxyglucose uptake in bronchial carcinomas. J Nucl Med 34:355–359

    PubMed  CAS  Google Scholar 

  56. Lewis P, Griffin S, Marsden P, Gee T, Nunan T, Malsey M, Dussek J (1994) Whole-body 18F-fluorodeoxyglucose positron emission tomography in preoperative evaluation of lung cancer. Lancet 344:1265–1266

    Article  PubMed  CAS  Google Scholar 

  57. Libshitz HI, McKenna RI, Haynie TP, McMurtrey MJ, Mountain CT (1984) Mediastinal evaluation in lung cancer. Radiology 151:295–299

    PubMed  CAS  Google Scholar 

  58. Lowe VJ, Fletcher JW, Gobar L, Lawson M, Kirchner P, Valk P, Karis J, Hubner K, Delbeke D, Heiberg EV, Patz EF, Coleman RE (1998) Prospective investigation of positron emission tomography in lung nodules. J Clin Oncol 16:1075–1084

    PubMed  CAS  Google Scholar 

  59. Lowe VJ, Hoffman JM, DeLong DM, Patz EF, Coleman RE (1994) Semiquantitative and visual analysis of FDG-PET images in pulmonary abnormalities. J Nucl Med 35:1771–1776

    PubMed  CAS  Google Scholar 

  60. Lowe VJ, Patz E, Harris L, Hoffman JM, Hanson M, Goodman P, Coleman RE (1997) FDG-PET of pleural abnormalities. J Nucl Med 37(Suppl):228P (abstr)

    Google Scholar 

  61. Malenka DJ, Colice GL, Beck JR (1991) Does the mediastinum of patients with non-small cell lung cancer require histologic staging? Future standards for computed tomography. Am Rev Respir Dis 144:1134–1139

    Article  PubMed  CAS  Google Scholar 

  62. McLoud TC, Bourgouin PM, Greenberg RW, Kosiuk JP, Templeton PA, Shepard JO, Moore EH, Wain JC, Mathisen DJ, Grillo HC (1992) Bronchogenic carcinoma: analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling. Radiology 182:319–323

    PubMed  CAS  Google Scholar 

  63. Medina Gallardo JF, Borderas Naranjo F, Torres Cansino M, Rodriguez-Panadero F (1992) Validity of enlarged mediastinal nodes as markers of involvement by non-small cell lung cancer. Am Rev Respir Dis 146:1210–1212

    PubMed  CAS  Google Scholar 

  64. Midthun DE, Swensen SJ, Jett JR (1992) Clinical strategies for solitary pulmonary nodules. Annu Rev Med 43:195–208

    Article  PubMed  CAS  Google Scholar 

  65. Minn H, Paul R (1992) Cancer treatment monitoring with fluorine-18 2-fluoro-2deoxy-D-glucose and positron emission tomography: frustration or future. Eur J Nucl Med 19:921–924

    Article  PubMed  CAS  Google Scholar 

  66. Minn H, Zasadny KR, Quint LE, Wahl RL (1995) Lung cancer: reproducibility of quantitative measurement for evaluating 2-[18F]-fluoro-2-deoxy-D-glucose uptake at PET. Radiology 196:167–173

    PubMed  CAS  Google Scholar 

  67. Minna JD (1991) Neoplasms of the lung. In: Wilson JD, Braunwald E, Isselbacher KJ, Petersdorf RG, Martin JB, Fauci AS, Root RK (eds) Harrison’s Principles of Internal Medicine. McGraw-Hill, New York, pp 1102–1110

    Google Scholar 

  68. Miyauchi T, Wahl RL (1996) Regional 2-[18F]fluoro-2-deoxy-D-glucose uptake varies in normal lung. Eur J Nucl Med 23:517–523

    Article  PubMed  CAS  Google Scholar 

  69. Mountain CF, Dresler CM (1997) Regional lymph node classification for lung cancer staging. Chest 111:1718–1723

    Article  PubMed  CAS  Google Scholar 

  70. Nettelbladt OS, Sundin AE, Valind SO, Gustafsson GR, Lamberg K, Langström B, Björnsson EH (1998) Combined fluorine-18-FDG and Carbon-11-methionine PET for diagnosis of tumors in lung and mediastinum. J Nucl Med 39:640–647

    PubMed  CAS  Google Scholar 

  71. Nolop KB, Rhodes CG, Brudin LH, Beaney RP, Krausz T, Jones T, Hughes JMB (1987) Glucose utilization in vivo by human pulmonary neoplasms. Cancer 60:2682–2689

    Article  PubMed  CAS  Google Scholar 

  72. Oriuchi N, Inoue T, Tomiyoshi K, Sando Y, Tsukakoshi M, Aoyagi K, Tomaru Y, Ama-no S, Endo K (1998) Comparative F-18-fluoro-a-methyl-tyrosine (FMT) and FDGPET in patients with pulmonary tumors. Eur J Nucl Med 25:1019 (abstr)

    Article  Google Scholar 

  73. Patz EF, Lowe VJ, Goodman PC, Herndon J (1995) Thoracic nodal staging with PET imaging with 18FDG in patients with bronchogenic carcinoma. Chest 108:1617–1621

    Article  PubMed  Google Scholar 

  74. Patz EF, Lowe VJ, Hoffman JM, Paine SS, Harris LK, Goodman PC (1994) Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-Dglucose. Radiology 191:379–382

    PubMed  Google Scholar 

  75. Patz EF, Lowe VJ, Hoffman JM, Paine SS, Burrowes P, Coleman RE, Goodman PC (1993) Focal pulmonary abnormalities: evaluation with F- 18 fluorodeoxyglucose PET scanning. Radiology 188:487–490

    PubMed  Google Scholar 

  76. Quint LE, Francis IR, Wahl RL, Gross BH, Glazer GM (1995) Preoperative staging of non-small-cell carcinoma of the lung: imaging methods. AJR 164:1349–1359

    PubMed  CAS  Google Scholar 

  77. Rege SD, Hoh CK, Glaspy JA, Aberle DR, Dahlbom M, Razavi MK, Phelps ME, Hawkins RA (1993) Imaging of pulmonary mass lesions with whole-body positron emission tomography and fluorodeoxyglucose. Cancer 72:82–90

    Article  PubMed  CAS  Google Scholar 

  78. Reske SN, Bares R, Büll U, Guhlmann A, Moser E, Wannenmacher MF (1996) Klinische Wertigkeit der Positronen-Emissions-Tomographie (PET) bei onkologischen Fragestellungen: Ergebnisse einer interdisziplinären Konsensuskonferenz. Nuklearmedizin 35:45–52

    Google Scholar 

  79. Rhodes CG, Hughes JMB (1995) Pulmonary studies using positron emission tomography. Eur Respir J 8:1001–1017

    PubMed  CAS  Google Scholar 

  80. Rigo R, Paulus P, Kaschten BJ, Hustinx R, Bury T, Jerusalem G, Benoit T, FoidartWillems J (1996) Oncological applications of positron emission tomography with fluorine-18fluorodeoxyglucose. Eur J Nucl Med 23:1641–1674

    Article  PubMed  CAS  Google Scholar 

  81. Sasaki M, Ichiya Y, Kuwabara Y, Akashi Y, Yoshida T, Fukumura T, Murayama S, Ishida T, Sugio K, Masuda K (1996) The usefulness of FDG positron emission tomography for the detection of mediastinal lymph node metastases in patients with non-small cell lung cancer: a comparative study with X-ray computed tomography. Eur J Nucl Med 23:741–747

    Article  PubMed  CAS  Google Scholar 

  82. Sazon DAD, Santiago SM, Soo Hoo GW, Khonsary A, Brown C, Mandelkern M, Bland W, Williams AJ (1996) Fluorodeoxyglucose-positron emission tomography in the detection and staging of lung cancer. Am Respir Crit Care Med 153:417–421

    CAS  Google Scholar 

  83. Scott WJ, Gobar LS, Hauser LG, Sunderland JJ, Dewan NA, Sugimoto JT (1995) Detection of scalene lymph node metastases from lung cancer. Chest 107:1174–1176

    Article  PubMed  CAS  Google Scholar 

  84. Scott WJ, Schwabe JL, Gupta NC, Dewan NA, Reeb SD, Sugimoto JT (1994) Positron emission tomography of lung tumors and mediastinal lymph nodes using [18F]fluorodeoxyglucose. Ann Thorac Surg 58:698–703

    Article  PubMed  CAS  Google Scholar 

  85. Shields AF, Mankoff DA, Link JM, Graham MM, Eary JF, Kozawa SM, Zheng M, Le-wellen B, Lewellen TK, Grierson JR, Krohn KA (1998) Carbon-11-thymidine and FDG to measure therapy response. J Nucl Med 39:1757–1762

    PubMed  CAS  Google Scholar 

  86. Slosman DO, Spiliopoulos A, Couson F, Nicod L, Louis O, Lemoine R, Donath A, Junod AF (1993) Satellite PET and lung cancer: a prospective study in surgical patients. Nucl Med Commun 14:955–961

    Article  PubMed  CAS  Google Scholar 

  87. Slosman DO, Spiliopoulos A, Keller A, Lemoine R, Besse F, Couson F, Townsend D, Rochst T (1994) Quantitative metabolic PET imaging of a plasma cell granuloma. J Thorac Imag 9:116–119

    Article  CAS  Google Scholar 

  88. Steinert HC, Hauser M, Alleman F, Engel H, Berthold T, von Schulthess GK, Weder W (1997) Non-small cell lung cancer: nodal staging with FDG PET versus CT correlative lymph node mapping and sampling. Radiology 202:441–446

    PubMed  CAS  Google Scholar 

  89. Strauss LG, Conti PS (1991) The applications of PET in clinical oncology. J Nucl Med 32:623–648

    PubMed  CAS  Google Scholar 

  90. Stroobants S, Vansteenkiste J, Dupont P, DeLeyn P, DeWever W, Verbeken E, Deneffe G, Mortelmans L (1998) Value of FDG-PET in the evaluation of downstaging after induction chemotherapy in patients with non-small cell lung cancer (NSCLC). Eur J Nucl Med 25:921 (abstr)

    Google Scholar 

  91. Takahashi N, Fujibayashi Y, Yonekura Y, Welch MJ, Waki A, Tsuchida S, Nakamura S, Sadato N, Sugimoto K, Yamamoto K, Yokoyama TA, Ishii Y (1998) Evaluation of copper-62 ATSM in patients with lung cancer as a hypoxic tissue tracer. J Nucl Med 39:53P (abstr)

    Google Scholar 

  92. Tewson TJ, Krohn KA (1998) PET radiopharmaceuticals: state-of-the-art and future aspects. Sem Nucl Med 28:221–234

    Article  CAS  Google Scholar 

  93. Valk PE, Pounds TR, Hopkins DM, Haseman MK, Hofer GA, Greiss FIB, Myers RW, Lutrin CL (1995) Staging non-small cell lung cancer by whole-body positron emission tomographic imaging. Ann Thorac Surg 60:1573–1582

    Article  PubMed  CAS  Google Scholar 

  94. Vansteenkiste JF, Stroobants SG, Dupont PJ, De Leyn PR, De Weyer WF, Verbeken EK, Nuyts JL, Maes FP, Bogaert JG, and the Leuven Cancer Group (1998) FDG-PET scan in potentially non-small cell lung cancer: do anatometabolic PET-CT fusion images improve the localisation of regional lymph node metastases? Eur J Nucl Med 25:1495–1501

    Article  PubMed  CAS  Google Scholar 

  95. Vansteenkiste JF, Stroobants SG, De Leyn PR, Dupont PJ, Bogaert J, Maes A, Deneffe GJ, Nackaerts KL, Verschakelen JA, Lerut TE, Mortelmans LA, Demedts MG (1998) Lymph node staging in non-small cell lung cancer with FDG-PET scan: a prospective study on 690 lymph node stations from 68 patients. J Clin Oncol 16:2142–2149

    PubMed  CAS  Google Scholar 

  96. Wahl RL, Quint LE, Greenough RL, Meyer CR, White RI, Orringer MB (1994) Staging of mediastinal non-small cell lung cancer with FDG PET, CT, and fusion images: preliminary prospective evaluation. Radiology 191:371–377

    PubMed  CAS  Google Scholar 

  97. Webb WR (1990) Radiologic evaluation of the solitary pulmonary nodule. AJR 154:701–708

    PubMed  CAS  Google Scholar 

  98. Weber W, Voll B, Treumann, Watzlowik P, Präuer H, Schwaiger M (1998) Positronenemissionstomographie mit C-11-Methionin und F-18-Fluorodeoxyglukose in der Diagnostik des Bronchialkarzinoms. Nuklearmedizin 37:A37 (abstr)

    Google Scholar 

  99. Weder W, Schmid RA, Bruchhaus H, Hillinger S, von Schulthess GK, Steinert HC (1998) Detection of extrathoracic metastases by positron emission tomography in lung cancer. Ann Thorac Surg 66:886–893

    Article  PubMed  CAS  Google Scholar 

  100. Wittekind CH, Wagner G (1997) TNM-Klassifikation maligner Tumoren. Springer, Berlin Heidelberg New York

    Google Scholar 

  101. Wolf M, Havemann K, Schneider P, Vogt-Moykopf I, Budach V (1997) Nichtkleinzelliges Bronchialkarzinom. In: Schmoll HJ, Höffken K, Possinger K (eds) Kompendium internistische Onkologie - Teil 2. Springer, Berlin Heidelberg New York, pp 558–600

    Google Scholar 

  102. Zasadny KR, Wahl RL (1993) Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose: variations with body weight and a method for correction. Radiology 189:847–850

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. B. Klemenz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. M. Taaleb
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Bundeswehrzentralkrankenhaus Koblenz, Abteilung XV - Nuklearmedizin, Rübenacher Straße 170, Koblenz, 56072, Germany

    H. J. Wieler

  2. Division of Nuclear Medicine, Department of Radiology, DUMC 3949, Room 1419, Duke North Erwin Road, Durham, NC, 27710, USA

    R. Edward Coleman M.D. (Professor of Radiology, Vice-Chairman, Director) (Professor of Radiology, Vice-Chairman, Director)

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Klemenz, B., Taaleb, K.M. (2000). Lung cancer. In: Wieler, H.J., Coleman, R.E. (eds) PET in Clinical Oncology. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57703-1_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57703-1_16

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63329-4

  • Online ISBN: 978-3-642-57703-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation