Current status of PET in the United States

  • R. E. Coleman
  • H. J. Wieler


PET imaging is having a major impact in patient care. The increasing utilization of PET is related to several major factors: clinical data demonstrating the usefulness, reimbursement, availability of instrumentation and distribution of FDG. We are just beginning to see the “tip of the iceberg” in the clinical and research utilization of PET. PET is a molecular imaging technique, and PET imaging will be the major imaging modality of molecular medicine. The ability to label molecules with positron-emitting radionuclides and quantitatively determine their distribution will be important in disease characterization, drug discovery, drug therapy and gene therapy [8]. These uses will frequently begin with the mouse, which is the animal most widely used in drug development and in gene therapy. Systems such as the microPET permit high resolution (1-2 mm) of PET tracers in small animals including mice [2, 12]. These studies can then be performed in adult subjects to verify the results obtained in animals. The ethical drug industry is beginning to adapt this technology in their developmental efforts.


Positron Emission Tomography Positron Emission Tomography Imaging Positron Emission Tomography Scanner Positron Emission Tomography Tracer Coverage Policy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Al-Aish M, Coleman RE, Larson SM, et al. (1990) Advances in clinical imaging using positron emission tomography. National Cancer Institute Workshop Statement. Arch Int Med 150:735–739CrossRefGoogle Scholar
  2. [2]
    Chatziioannou AF, Cherry SR, Shao Y, et al. (1999) Performance evaluation of micro-PET: a high-resolution lutetium oxyorthosilicate PET scanner for animal imaging. J Nucl Med 40(7):1164–1175PubMedGoogle Scholar
  3. [3]
    Coleman RE (1997) Editorial: Camera-based PET: the best is yet to come. J Nucl Med 38(11):1796–1797PubMedGoogle Scholar
  4. [4]
    Coleman RE (1998) Clinical PET in oncology. Clinical Positron Imaging 1:15–30PubMedCrossRefGoogle Scholar
  5. [5]
    Coleman RE, Tesar RD (2000) A perspective on clinical PET imaging. Clin Pos Imag 3:41–44CrossRefGoogle Scholar
  6. [6]
    Coleman RE, Robbins MS, Siegel BA (1992) The future of PET in clinical medicine and the impact of drug regulation. Semin Nucl Med 12:193–201Google Scholar
  7. [7]
    Kuhl DE, Wagner HN, Alavi A, Coleman RE, Larson SM, Mintun MA, Siegel BA, Strudler PK (1988) Positron emission tomography (PET): Clinical status in the United States in 1987. J Nucl Med 29:1136–1143Google Scholar
  8. [8]
    Phelps ME, Coleman RE (2000) Editorial: Nuclear medicine in the new millennium. J Nucl Med 41:1–4PubMedGoogle Scholar
  9. [9]
    Phelps ME, Hoffman EJ, Coleman RE, Welch MJ, Raichle ME, Weiss ES, Sobel BE, TerPogossian MM (1976) Tomographic images of blood pool and perfusion in brain and heart. J Nucl Med 17:603–612PubMedGoogle Scholar
  10. [10]
    Phelps ME, Hoffman EJ, Mullani NA, Ter-Pogossian MM (1975) Application of annihilation coincidence detection to transaxial reconstruction tomography. J Nucl Med 16:210–224PubMedGoogle Scholar
  11. [11]
    Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology (1991) (Panel members: Mazziotta J, Coleman RE, Di Chiro G, Foster N, Fox P, Frackowiak R, Gilman S, Martin W, Raichle M, Theodore W) Assessment: Positron emission tomography. Neurology 41:163–167Google Scholar
  12. [12]
    Tornai MP, Jaszczak RJ, Turkington TG, Coleman RE (1999) Editorial: Small-animal PET: advent of a new era of PET research. J Nucl Med 40:1176–1179PubMedGoogle Scholar
  13. [13]
    Wieler HJ (1999) PET in der klinischen Onkologie. Steinkopff Verlag, DarmstadtGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • R. E. Coleman
  • H. J. Wieler

There are no affiliations available

Personalised recommendations