Skip to main content
SpringerLink
Log in

Pathogenese der Atherosklerose

  • Chapter
Koronarstenting

  • 85 Accesses

Zusammenfassung

Der Ausdruck „Arteriosklerose“ beschreibt den pathologisch-anatomischen Zustand der Verhärtung (=skleros) von Arterien. Diese Sklerose und die sich daraus ergebende Funktionseinschrankung der Arterie kann sich auf dem Boden unterschiedlicher Erkrankungen entwickeln.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bauriedel B, Schmücking I, Hutter R, Luchesi C, Welsch U, Kandlof R, Lüderitz B(1997) Vermehrte Apoptose und Nekrose in koronaren Plaques bei instabiler Angina. Z Kardiol 86:902–910

    Article  PubMed  CAS  Google Scholar 

  2. Bhakdi S, Dorweiler B, Kirchmann R, Torzewski J, Weise J, Tranum Jensen J, WalevI, Wieland E (1999) On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moiety. J Exp Med 182:1959–1971

    Article  Google Scholar 

  3. Geng YJ, Libby P (1995) Evidence for apoptosis in advanced human atheroma. Co-location with interleukin-1-beta converting enzyme. Am J Pathol 147:251–266

    PubMed  CAS  Google Scholar 

  4. Hardwick SJ, Hegyi L, Clare K, Law NS, Carpenter KLH, Mitchinson M (1996) Apoptosis in human monocytes macrophages exposed to oxidized low density lipoprotein. J Pathol 179:294–302

    Article  PubMed  CAS  Google Scholar 

  5. Markus HS, Sitzer M, Carrington D, Mendall MA, Steinmetz H (1999) Chlamydiapneumoniae infection and early asymptomatic carotid atherosclerosis. Circulation 100:832–837

    Article  PubMed  CAS  Google Scholar 

  6. Melnick SL, Shahar E, Fiksin AR, Grayston JT, Sorlie PD, Wang SP, Szklo M (1993) Past infektion by Chlamydia pneumoniae strein TWAR and asymptomatic carotidatherosclerosis. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Am J Med 95:499–504

    Article  PubMed  CAS  Google Scholar 

  7. Nieto FJ, Adam E, Sorlie P, Farzadegan H, Mlenick JL, Comstock GW, Szkolo M (1996) Cohort study of cytomegalovirus infektion as a risk factor for carotid inti-mal-medial thickening, a measure of subclinical atherosclerosis. Circulation 94:922–927

    Article  PubMed  CAS  Google Scholar 

  8. Rokitanski C v. Über einige der wichtigsten Erkrankungen der Arterien. KuKStaatsdruckerei Wien 1852. Zitiert aus Rieger H, Schoop W (1998) Klinische An-giologie. Allgemeine Stadieneinteilung, Ätiologie und Pathogenese der Arterioskle-rose. Springer, Berlin Heidelberg New York. S 16–74

    Google Scholar 

  9. Ross R, Raines EW, Bowen-Pope DF (1986) The biology of platelet-derived growthfactor. Cell 46:155–169

    Article  PubMed  CAS  Google Scholar 

  10. Stary HC, Blankenhorn DH, Chandler AB, Glagov S, Insull W, Richardson M, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, Wissler RW (1992) A Definition of the intima of human arteries and of its atherosclerosis prone regions: a report from the committee on vascular lesions of the council on ateriosclerosis,American Heart Association. Circulation 85:391–405

    Article  PubMed  CAS  Google Scholar 

  11. Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW (1995) A Definition of advanced Type ofatherosclerotic lesions and a histological classification of atherosclerosis. A reportfrom the committee on vascular lesions of the council on ateriosclerosis, AmericanHeart Association. Circulation 92:1355–1374

    Article  PubMed  CAS  Google Scholar 

  12. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, Wissler RW (1994) A definition of initial, fattystreak and intermediate lesions of atheriosclerosis: a report from the committee onvascular lesions of the council on ateriosclerosis, American Heart Association. Arterioscler Throm 14:840–856

    Article  CAS  Google Scholar 

Literatur

  1. Alfonso F, Goicolea J, Hernandez R, Fernandez-Ortiz A, Segovia J, Banuelos C, Ara-goncillo P, Phillips P, Macaya C (1996) Arterial perforation during optimisation of coronary stents using high-pressure balloon inflations. Am J Cardiol 78(10): 1169–1172

    Article  PubMed  CAS  Google Scholar 

  2. Anderson PG, Bajaj RK, Baxley WA, Roubin GS (1992) Vascular pathology of balloonexpandable coil stents in humans. J Am Coll Cardiol 19:372–381

    Article  PubMed  CAS  Google Scholar 

  3. Bauters C, Hubert E, Prat A, Bougrimi K, Van Belle E, McFadden EP, Amouyel P, Lablanche JM, Bertrand M (1998) Predictors of restenosis after coronary stent implantation. J Am Coll Cardiol 31(6):1291–1298

    Article  PubMed  CAS  Google Scholar 

  4. Beusekom van HM, Whelan DM, Hofma SH, Krabbendam SC, van Hinsbergh VW, Verdouw PD, van der Giessen WJ (1998) Long-term endothelial dysfunction ismore pronounced after stenting than after balloon angioplasty in porcine coronaryarteries. J Am Coll Cardiol 32:1109–1117

    Article  PubMed  Google Scholar 

  5. Carter AJ, Laird JR, Farb A, Kufs W, Wothham DC, Virmani R (1994) Morphologic Characteristics of lesion formation and time course of smooth muscle cell proliferation in a porcine proliferative restenosis model. J Am Coll Cardiol 24(5):1398–1405

    Article  PubMed  CAS  Google Scholar 

  6. Champley-Campbell J, Campbell GR, Ross R. The smooth muscle cell in culture (1979) Physiol Rev 59:1–61

    Google Scholar 

  7. Clowes AW, Reidy MA, Clowes MM (1983) Kinetics of cellular proliferation afterartery injury. Smooth muscle cell growth in absence of endothelium. Lab Invest 49:327–333

    PubMed  CAS  Google Scholar 

  8. Deneke T (2000) Expansionsdrucke zur Stentimplantation — morphologische undmorphometrische Befunde. Unveröff Diss Bochum

    Google Scholar 

  9. Esente P, Giambartolemei A, Reger MJ, Walford G, Johnson LW (1996) Extensivecoronary dissection caued by balloon rupture at high pressure stent deployment. Cathet Cardiovasc Diagn 38(3):263–265

    Article  PubMed  CAS  Google Scholar 

  10. Farb A, Sangiorgi G, Carter AJ, Walley VM, Edwards WD, Schwartz RS, Virmani R(1999) Pathology of acute and chronic coronary stenting in humans. Circulation 99:44–52

    Article  PubMed  CAS  Google Scholar 

  11. Fischman DL, Leon M, Bairn DS, Schatz RA, Savage M, Penn I, Detre K, Veltri L, Ricci D, Nobuyoshi M, Cleman M, Heuser R, Almond D, Teirstein P, Fish D, Colombo A, Brinker J, Moses J, Hirshfeld JW, Bailey S, Ellis S, Rake R, Goldberg S (1994) A randomised comparison of coronary stent placement and baloon angio-plasty in the treatment of coronary artery disease. N Engl J Med 331:496–501

    Article  PubMed  CAS  Google Scholar 

  12. Frid MG, Dempsey EC, Durmowicz AG, Stenmark KR (1997) Smooth muscle cellheterogeneity in pulmonary and systemic vessels: importance in vascular desease. Arterioscler Thromb Vase Biol 17:1203–1209

    Article  CAS  Google Scholar 

  13. Furchgott RF, Zawadzki JV (1980). The obligatory role of endothelial cells in therelaxation of arterial smooth muscle by acetylcholine. Nature 288:373–376

    Article  PubMed  CAS  Google Scholar 

  14. Goldberg SL, Di Mario C, Hall P, Colombo A (1998) Comparison of aggressive versus nonaggresive balloon dilatation for stent deployment on late lost and restenosisin native coronary arteries. Am J Cardiol 81(6):708–712

    Article  PubMed  CAS  Google Scholar 

  15. Gonschior P, Gerheuser F, Lehr HA, Welsch U, Höfling B (1995) Ultrastructural characteristics of cellular reaction after experimentally induced lesions in the arterial vessel. Basic Res Cardiol 90:160–166

    Article  PubMed  CAS  Google Scholar 

  16. Grewe PH, Machraoui A, Deneke T, Barmeyer J, Müller KM (1997) Pathogenesis of neointima-generation after coronary stentimplantation. Circulation 96:1–403

    Google Scholar 

  17. Grewe PH, Machraoui A, Deneke T, Barmeyer J, Müller K-M (1997) Strukturanalyse von 16 verschiedenen Coronarstentsystemen. Z Kardiol 86:990–999

    Article  PubMed  CAS  Google Scholar 

  18. Grewe PH, Deneke T, Machraoui A, Barmeyer J, Müller KM (2000) Acute and chronic tissue response to coronary stent implantation: Pathologic findings in human specimen. JACC 35:157–163

    PubMed  CAS  Google Scholar 

  19. Holifield B, Helgason T, Jemelka S, Taylor A, Navran S, Alen J, Seidel C (1996) Differentiated vascular myocytes: are they involved in neointimal formation? J ClinInvest 97:814–825

    Article  CAS  Google Scholar 

  20. Karas SP, Gravains MG, Satoian EC (1992) Coronary intimal proliferation after balloon injury and stenting in swine: An animal model of restenosis. J Am Coll Cardiol 20:467–474

    Article  PubMed  CAS  Google Scholar 

  21. Kearney M, Pieczek A, Haley L, Schainfeld R, Rosenfield K, Isner JM (1996) Histopathology of Stentrestenosis. Circulation 94:1–620

    Article  Google Scholar 

  22. Komatsu R, Ueda M, Naruko T (1998) Neointimal Tissue Response at Sites of Coronary Stenting in Humans. Marcroscopic, Histological, and Immunohistochemical Analyses. Circulation 98:224–233

    Article  PubMed  CAS  Google Scholar 

  23. Palmaz JC, Sibbitt RR, Reuter SR (1985). Expandable intraluminal graft: A preliminary Study. Work in progress. Radiology 156:73–77

    PubMed  CAS  Google Scholar 

  24. Peters RJG, Kok WEM, Di Mario C, Serruys PW, Bär FWH, Pasterkamp G, Borst C, Kamp O, Bronzwaer JGF, Visser CA, Piek JJ, Panday RN, Jaarsma W, Savalle L, Bom N (1997) Prediction of restenosis after balloon angioplasty results of the PIC TURE Post — (Intra Coronary Treatment Ultrasound Result Evaluation) — A pro-spectiv multicenter intracoronary ultrasound study. Circulation 95:2254–2261

    Article  PubMed  CAS  Google Scholar 

  25. Rogers C, Parikh S, Seifert P, Edelman ER (1996) Endogenous cell seeding. Remnant endothelium after stenting enhances vascular repair. Circulation 94:2909–2914

    Article  PubMed  CAS  Google Scholar 

  26. Ross R, Raines EW, Bowen-Pope DF (1986) The biology of platelet-derived growth factor. Cell 46:155–169

    Article  PubMed  CAS  Google Scholar 

  27. Schwartz RS, Murphy JG, Edwards WD, Camrud AR, Vliestra, Holmes DR (1990) Restenosis after balloon angioplasty. A practical proliferative model in porcine coronary arteries. Circulation 82:2190–2200

    Article  PubMed  CAS  Google Scholar 

  28. Scott NA, Gustavo DC, Ross CE, Dunn B, Martin FH, Simonet L, Wilcox JN (1996) Identifikation of a Potential Role for the Adventitia in Vascular Lesion Formation after Ballon overstretch Injury of Porcine Coronary Arteries. Circulation 93:2178–2187

    Article  PubMed  CAS  Google Scholar 

  29. Serruys PW, de Jaegere P, Kiemeneij F, Macaga C, Rutsch W, Heyndrickx G, Emanuelsson H, Marco J, Legrand V (1994) For the Benestent Study Group: A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. N Engl J Med 331(6):489–495

    Article  PubMed  CAS  Google Scholar 

  30. Stick P, Schumann E, Zindler G, Heisterhagen A, Junghans U, Lauer B, Zotz R, Hambrecht R, Krankenberg H, Spranger C, Mohr F, Schlueter G (1997) Comparative studies of the rate of restenosis after implantation of Palmaz-Schatz and Ave-Micro stents. Z Kardiol 86(12):1000–1009

    Article  Google Scholar 

  31. Strauss BH, Umans VA, Sylenv RJ, de Feyter PJ, Marco J, Robertson GC (1992) Directional atherectomy for treatment of restenosis within coronary stents: Clinical, angiographic and histologic results. J Am Coll Cardiol 20:1465–1473

    Article  PubMed  CAS  Google Scholar 

  32. Thyberg J (1996) Differentiated properties and proliferatin of arterial smooth muscle cells in culture. Int Rev Cytol 169:183–265

    Article  PubMed  CAS  Google Scholar 

  33. Werner GS, Gastmann O, Ferrari M, Schuenemann S, Knies A, Dietrich J, Kreuzer H (1998) Risk factors of acute and subacute stent thrombosis after high-pressure stent implantation: a study by intracoronary ultrasound. Am Heart J 135:300–309

    Article  PubMed  CAS  Google Scholar 

Literatur

  1. Amon M, Bolz A, Schaldach M (1996) Improvement of stenting therapy with a silicon coated tantalum stent. J Mater Med 7:273–278

    Article  CAS  Google Scholar 

  2. Bauerschmidt P, Schaldach M (1977) The electrochemical aspects of the thrombogenicity of a material. Journal of Bioengeneering 1:261–278

    Google Scholar 

  3. Campbell R, Edelman ER (1995) Endovascular stent design dictates experimental restenosis and thrombosis. Circulation 91:2995–3000

    Article  Google Scholar 

  4. De Scheerder I, Sophier J, Wang K (1997) Metallic surface treatment using electrochemical polishing decreases thrombogenicity and neointimal hyperplasia after coronary stent implantation in a porcine model. Eur Heart J 18:153–156

    Google Scholar 

  5. Franzen D, Nolte C, Haude M, v Stocmeier C, Albrecht D, Heublein B, Erbel R, Hopp HW (1994) Zeitverlauf und Charakteristika von Restenosen nach koronarer Stentimplantation bei asymptomatischen und symptomarmen Patienten. Z Kardiol 83:155–160

    PubMed  CAS  Google Scholar 

  6. Fuster V, Badimon JJ, Badimon L (1992) Clinical-pathological correlations of coronary disease progression and regression. Circulation suppl. III. Vol 86, Nr 6

    Google Scholar 

  7. Michanetzis GP, Missirlis A (1992). Flow dependent platelet behaviour in bloodmaterial interactions. Biomedizinische Technik 37:29–33

    Google Scholar 

  8. Palmaz JC, RR Sibbit, SR Reuter, FO Tio, WJ Rice (1985) Expandabel intraluminal graft: A preliminary study. Radiology 156:73–77

    PubMed  CAS  Google Scholar 

  9. Sheth R, Dev V, Jacobs H, Forester J, Litvak F, Eigler N (1995) Prevention of sub-acute stent thrombosis by polymer-polyethylene oxide-heparin coating in the rabbit carotid artery. J Am Coll Cardiol 25:348A

    Article  Google Scholar 

  10. Williams DF, Askill IN, Smith R (1985) Protein adsorption and desorption phenomena on clean metal surfaces. J Biomed Mater Res 19:313–320

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. P. H. Grewe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K.-M. Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Grewe, P.H., Müller, KM. (2001). Pathogenese der Atherosklerose. In: Koronarstenting. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57637-9_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57637-9_3

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63321-8

  • Online ISBN: 978-3-642-57637-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation