Zusammenfassung
Diuretika zählen zu den ältesten in der Hypertoniebehandlung verwandten Medikamenten und werden in den meisten Ländern als sog. First-line-Antihypertensiva eingestuft; eine Reduktion von Morbidität und Mortalität unter Langzeiteinnahme von Diuretika konnte in mehreren prospektiven Studien (Tab. 21.1) nachgewiesen werden.
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Literatur
Carlsen JE, Kober L, Torp-Pederson L, Johansen P (1990) Relation between dose of bendrofluazide, antihypertensive effect, and adverse biochemical effects. Br Med J 300:975–978
Cauley JA, Cummings SR, Seeley DG, Black D, Browner W, Kuller LH, Nevitt MC (1993) Effects of thiazide diuretic therapy on bone mass, fractures, and falls. Ann Intern Med 118:666–673
Collins R, Peto R, MacMahon et al (1990) Blood pressure, stroke, and coronary heart disease. Part 2, short term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 335:827–838
Dahlöf B, Lindholm LH, Hansson L, Schersten B, Ekbom T, Wester PO (1991) Morbidity and mortality in the Swedish trial in Old Patients with Hypertension (STOP-Hypertension). Lancet 338:1281–1285
Dirks JH, Sutton RAL (eds) (1986) Diuretics: physiology, pharmacology and clinical use. WB Saunders, Philadelphia
Franse LV, Pahor M, Di Bari M, Somes GW, Cushman WC, Applegate WB (2000) Hypokalemia associated with diuretic use and cardiovascular events in the Systolic Hypertension in the Elderly Program. Hypertension 35:1025–1030
Gress TW, Nieto FJ, Shahar E, Wofford MR, Brancati FL (2000) For the Atherosclerosis Risk in Communities Study. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. N Engl J Med 342:905–912
Grossmann E, Messerli FH, Goldbourt U (1999) Does diuretic therapy increase the risk of renal cell carcinoma in women? Am J Cardiol 83:1090–1093
Hampton JR (1992) Comparative efficacy of diuretics: benefit versus risk: results of clinical trials. Europ Heart J 13(Suppl G):85–91
Harper R, Ennis CN, Sheridan B, Atkinson AB, Johnston GD, Bell PM (1994) Effects of low dose versus conventional dose thiazide diuretic on insulin action in essential hypertension. Br Med J 309:226–230
Knauf H, Mutschier E (1995) Diuretic effectiveness of hydrochlorothiazide and furosemide alone and in combination in chronic renal failure. J Cardiovasc Pharmacol 26:394–400
LaCroix AZ, Ott SM, Ichilawa L, Scholes D, Balow WE (2000) Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 133:516–526
Lip GYH, Ferner RE (1999) Diuretic therapy for hypertension: a cancer risk? J Hum Hypertension 13:421–423
Moser M (1998) Why are physicians not prescribing diuretics more frequently in the management of hypertension. JAMA 279:1813–1816
MRC Working Party (1985) Medical Research Council trial of treatment of hypertension in older adults: principal results. Br Med J 304:405–412
Neaton JD, Grimm RH Jr, Prineas RJ, Stamler J, Grandits GA, Elmer PJ, Cutler JA, Flack JM, Schoenberger JA, McDonald R, Lewis CE, Liebson PR (1993) Treatment of mild hypertension study (TOMHS): final results. JAMA 270:713–724
Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J (1999) For the Randomized Aldactone Evaluation Study Investigators. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 341:709–717
Shapiro JA, Williams MA, Weiss NS, Stergachis A, LaCroix AZ, Barlow WE (1999) Hypertension, antihypertensive medication use, and risk of renal cell carcinoma. Am J Epidemiol 149:521–530
SHEP Cooperative Research Group (1991) Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hapertension. Final results of the Systolic Hypertension in the Elederly Program (SHEP). JAMA 265:3255–3264
Siscovick DS, Raghunathan TE, Psaty BM, Koepsell TD, Wicklund KG, Lin X, Cobb L, Rautaharju PM, Copass MK, Wagner EH (1994) Diuretic therapy for hypertension and the risk of primary cardiac arrest. N Engl J Med 330:1852–1857
Storstein L (1992) Diuretics, arrhythmias and silent myocardial ischaemia in hypertensive patients. Europ Heart J 13(Suppl G):81–84
Struthers AD (1999) Why does spironolactone improve mortality over and above an ACE inhibitor in chronic heart failure? Br J Clin Pharmacol 47:479–482
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (2000) Major cardiovascular events in hypertensive patients randomized to doxazosin vs. chlorthalidone. The Antihypertensive and Lipi-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 283:1967–1975
Wasnich RD, Davis JW, He YF, Petrovich H, Ross PD (1995) A randomized, double-masked, placebo-controlled trial of chlorthalidone and bone loss in elderly women. Osteoporosis Int 5:247–251
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Stimpel, M. (2001). Diuretika. In: Arterielle Hypertonie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57617-1_23
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