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Biologische Rezidivprophylaxe

  • Chapter
Interventionelle Gefäßtherapie

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Zusammenfassung

Die Restenoserate nach koronarer Ballonangioplastie (PTCA) [38] und anderen perkutanen Interventionen am Koronarsystem (PCI; Rot-ablation) [49,173], Atherektomie [7,124,193],Laserangioplastie [115,172] ist trotz intensiver experimenteller und klinischer Forschungsarbeiten weiterhin hoch. Die Verwendung von Stents hat nach großen klinischen Studien die Restenoserate von etwa 40-50% auf etwa 20-30% gesenkt [20,61,188,189], eine Reihe anderer Ansätze zur Restenoseprophylaxe wie die Brachytherapie [208,210] sind derzeit in der klinischen Evaluierung (siehe S. 420-424 Status der Rezidivprophylaxe). Die hierdurch notwendigen Reinterventionen stellen bisher angesichts von jährlich mehr als einer Million Interventionen weltweit nicht nur eine große Belastung für die betroffenen Patienten dar, sondern besitzen auch erhebliche gesundheits-ökonomische Bedeutung. D a bisher keine befriedigende Lösung des Problems erreicht worden ist, wurden in den letzten Jahren auch innovative experimentelle Ansätze zur Restenoseprophylaxe evaluiert.

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Authors
  1. W. Poller
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  2. H.-P. Schultheiss
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Editors and Affiliations

  1. Kardiologische Fachklinik Herz- und Kreislaufzentrum, Rotenburg an der Fulda, Heinz-Meise-Str. 100, Rotenburg a.d.F., 36199, Germany

    Christian Vallbracht

  2. LVA Aggertalklinik, Am Sondersiefen 18, Engelskirchen, 51766, Germany

    Franz-Josef Roth

  3. Abteilung für Angiologie, Dominikus-Krankenhaus Düsseldorf, Am Heerdter Krankenhaus 2, Düsseldorf, 40549, Germany

    Andreas L. Strauss (Chefarzt) (Chefarzt)

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Poller, W., Schultheiss, HP. (2002). Biologische Rezidivprophylaxe. In: Vallbracht, C., Roth, FJ., Strauss, A.L. (eds) Interventionelle Gefäßtherapie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57540-2_38

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  • DOI: https://doi.org/10.1007/978-3-642-57540-2_38

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63296-9

  • Online ISBN: 978-3-642-57540-2

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