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Therapeutische Angiogenese

  • M. G. Engelmann
  • S. Nikol

Zusammenfassung

Die Identifizierung angiogener Wachstumsfaktoren ermöglichte die Entwicklung neuartiger Strategien zur Behandlung chronischer Gefäßverschlüsse. Die therapeutische Angiogenese könnte eine potentielle alternative Therapie für Patienten mit einer kritischen Beinischämie auf dem Boden einer Kapillaraussprossung (Angiogenese) und der Neubildung von Kollateralgefäßen (Arteriogenese) darstellen. In-vitro-und experimentelle In-vivo-Untersuchungen konnten die Wirksamkeit der vermehrten Kollateralenbildung und funktionellen Durchblutungsverbesserung bei experimenteller Beinischämie sowohl für rekombinante Gefäßwachstumsfaktoren als auch für gentherapeutische Strategien nachweisen. Gentherapeutische Strategien besitzen den Vorteil einer Minimierung systemischer Nebenwirkungen und der langsamen und kontinuierlichen Freisetzung des kodierten Faktors, was einen länger anhaltenden angiogenen Effekt er-laubt. In überwiegend unkontrollierten klini­schen-Phase-I- und -IIa-Studien wurden die Machbarkeit und die Effizienz der Gefäßbe­handlungen mit Wachstumsfaktoren gezeigt. Die Ergebnisse plazebokontrollierter, und doppel­blinder Studien sind zur sicheren Beurteilung des therapeutischen Pozentials abzuwarten.

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© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • M. G. Engelmann
  • S. Nikol

There are no affiliations available

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