Skip to main content

Förderung der Arteriogenese

  • Chapter
Interventionelle Gefäßtherapie
  • 52 Accesses

Zusammenfassung

T rotz dramatischer Fortschritte in der Behandlung der koronaren Herzkrankheit mit einer über 50%igen Senkung der Mortalität in allen westlichen Ländern sind kardiovaskuläre Erkrankungen im Rahmen einer Atherosklerose, insbesondere die koronare Herzkrankheit, hinsichtlich Morbidität und Mortalität nach wie vor führend. Die bisherigen Maßnahmen zur akuten wie auch chronischen effizienten Behandlung dieser Volkskrankheit sind die perkutane Ballondilatation (PTCA) sowie die aortokoronare Bypassoperation (ACB), [21]. Beide Therapieformen haben das Ziel, die Gefäßstenose zu beseitigen oder zu umgehen, um damit den physiologischen Blutfluss in das ischämische periphere Gefäßbett wiederherzustellen. Alleine in Deutschland werden jedes Jahr mehr als 450 000 diagnostische Herzkatheteruntersuchungen durchgeführt. Von diesen Patienten wurden wiederum ca. 70000 konsekutiv Bypass-operiert sowie 125 000 Ballondilatiert (Stentimplantationen im Mittel 34,4%; [8]).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 59.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Arras M, Ito WD, Scholz D, Winkler B, Schaper J, Schaper W (1998) Monocyte activation in angiogenesis and collateral growth in the rabbit hind-limb. J Clin Invest 101:40–50

    Article  PubMed  CAS  Google Scholar 

  2. Buschmann I, Schaper W (1999) Angiogenesis versus arteriogenesis. News Physiol Sci 14:121–125

    PubMed  Google Scholar 

  3. Buschmann I, Höfer I, van Royen N, Katzer E, Braun-Dulleaus R, Heil M, Kostin S, Bode C, Schaper W (2001) GM-CSF: a strong arteriogenic factor acting by amplification of monocyte function. Atherosclerosis 159:343–356

    Article  PubMed  CAS  Google Scholar 

  4. Carmeliet PDC (1997) Genetic analysis of blood vessel formation: role of endothelial versus smooth muscle cells. Trends Cardiovasc Med 7:271–281

    Article  PubMed  CAS  Google Scholar 

  5. Carmeliet PDC (1998) Vascular development and disorders - molecular analysis and pathogenic insights. Kidney International 53:1519–1549

    Article  PubMed  CAS  Google Scholar 

  6. Deindl E, Buschmann I, Höfer IE, Podzuweit T, Boengler K, Vogel S, van Royen N, Fernandez B, Schaper W (2001) Role of ischemia and of hypoxia-inducible genes in arteriogenesis after femoral artery occlusion in the rabbit. Circ Res 89:779–786

    Article  PubMed  CAS  Google Scholar 

  7. Donnini S, Machein MR, Plate KH, Weich HA (1999) Expression and localization of placenta growth factor and P1GF receptors in human meningiomas. J Pathology 189:66–71

    Article  CAS  Google Scholar 

  8. Fulton WFM (1965) The coronary arteries, Charles C. Thomas Publishers, Springfield, IL

    Google Scholar 

  9. Gleichmann H, Mannebach P, Lichtlen P (1999) 12. Bericht über Struktur and Leistungszahlen der Herzkatheterlabors in der Bundesrepublik Deutschland. Vorstand der Deutschen Gesellschaft für Kardiologie- Herz-and Kreislaufforschung (Hrsg)http://www.uni-duesseldorf.de/WWW/DGK/Richtlinien/13berichhtm

    Google Scholar 

  10. Hamawy AH, Lee LY, Crystal RG, Rosengart TK (1999) Cardiac angiogenesis and gene therapy: a strategy for myocardial revascularization [Review]. Curr Opin Cardiol 14:515–522

    Article  PubMed  CAS  Google Scholar 

  11. Ito WD, Arras M, Scholz D, Winkler B, Htun P, Schaper W (1997) Angiogenesis but not collateral growth is associated with ischemia after femoral artery occlusion. Am J Physiol 273:H1255–1265

    PubMed  CAS  Google Scholar 

  12. Ito WD, Arras M, Winkler B, Scholz D, Schaper J, Schaper W (1997) Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion. Circ Res 80:829–837

    Article  PubMed  CAS  Google Scholar 

  13. Kosaki K, Ando J, Korenaga R, Kurokawa T, Kamiya A (1998) Fluid shear stress increases the production of granulocyte-macrophage colony-stimulating factor by endothelial cells via mRNA stabilization. Circulation Res 82:794–802

    Article  PubMed  CAS  Google Scholar 

  14. Longland CJ (1953) The collateral circulation of the limb. Ann Roy Coll Surg Engl 13:161–164

    CAS  Google Scholar 

  15. Marme D (1999) Tumor angiogenesis: molecular facts and therapeutic opportunities [Review] [German]. Chirurg 70:31–35

    Article  Google Scholar 

  16. Plate KH, Beck H, Danner S, Allegrini PR, Wiessner C (1999) Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct. J Neuropath Exper Neurol 58:654–666

    Article  CAS  Google Scholar 

  17. Risau W (1998) Development and Differentiation of Endothelium. Kidney International 54:S3–S6

    Article  Google Scholar 

  18. Schaper W, Buschmann I (1999) Collateral circulation and diabetes [editorial]. Circulation 99:22242246

    Google Scholar 

  19. Schaper W, Buschmann I (1999) Arteriogenesis, the good and bad of it. Cardiovasc Res 43:835–837

    Article  PubMed  CAS  Google Scholar 

  20. Schaper W, Buschmann I (1999) Collateral circulation and diabetes. Circulation 99:2224–2226

    Article  PubMed  CAS  Google Scholar 

  21. Shyy YJ, Hsieh HJ, Usami S, Chien S (1994) Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium. Proceedings of the National Academy of Sciences of the United States of America 91:4678–4682

    Article  PubMed  CAS  Google Scholar 

  22. website Ti:http://www.chd-taskforce.com

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Buschmann, I., Höfer, I., Schaper, W. (2002). Förderung der Arteriogenese. In: Vallbracht, C., Roth, FJ., Strauss, A.L. (eds) Interventionelle Gefäßtherapie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57540-2_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57540-2_28

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63296-9

  • Online ISBN: 978-3-642-57540-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics