Akuter Myokardinfarkt

  • M. P. Heintzen

Zusammenfassung

Für die Behandlung von Patienten mit akutem Myokardinfarkt ist die frühzeitige Reperfusion des Infarktareals von essentieller Bedeutung. In den letzten 25 Jahren hat sich die systemische Thrombolysetherapie als das am weitesten verbreitete Reperfusionsverfahren bei Patienten mit Myokardinfarkt durchgesetzt. Der klare Vorteil dieser medikamentösen Therapie besteht in der ubiquitären Verfügbarkeit und einer relativ hohen Erfolgsrate bei rechtzeitigem Einsatz.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Ahmad T, Webb JG, Carere RR, Dodek A (1995) Coronary stenting for acute myocardial infarction. Am J Cardiol 76:77–80PubMedCrossRefGoogle Scholar
  2. 2.
    Antoniucci D, Valenti R, Santoro GM, Bolognese L, Trapani M, Moschi G, Fazzini PF (1998) Systematic direct angioplasty and stent-supported direct angioplasty therapy for cardiogenic shock complicating acute myocardial infarction: in-hospital and longterm survival. J Am Coll Cardiol 31:294–300PubMedCrossRefGoogle Scholar
  3. 3.
    Antoniucci D, Valenti R, Santoro GM, Bolognese L, Trapani M, Moschi G, Fazzini PF (1999) Primary coronary infarct artery stenting in acute myocardial infarction. Am J Cardiol 84:505–510PubMedCrossRefGoogle Scholar
  4. 4.
    Azar RR, McKay RG, Thomson PD, Hirst JA, Mitchell JF, Fram DB, Waters DD, Kiernan FJ (1998) Abciximab in primary coronary angioplasty for acute myocardial infarction improves short-and medium-term outcomes. J Am Coll Cardiol 32:1996–2002PubMedCrossRefGoogle Scholar
  5. 5.
    Bauters C, Delomez M, Van Belle E, McFadden E, Lablanche JM, Bertrand ME (1999) Angiographically documented late reocclusion after successful coronary angioplasty of an infarct-related lesion is a powerful predictor of long-term mortality. Circulation 99:2243–2250PubMedCrossRefGoogle Scholar
  6. 6.
    Bellinger RL, Calif RM, Mark DB, Weber RA, Collins P, Stone J, Phillips HR 3d, German L, Stack RS (1988) Helicopter transport of patients during acute myocardial infarction. Am J Cardiol 61:718–722PubMedCrossRefGoogle Scholar
  7. 7.
    Brener SJ, Barr LA, Burchenal JE, Katz S, George BS, Jones AA, Cohen ED, Gainey PC, White HJ, Cheek HB, Moses JW, Moliterno DJ, Effron MB, Topol EJ (1998) Randomized, placebo-controlled trial of platelet glycoprotein IIb/ííía blockade with primary angioplasty for acute myocardial infarction. ReoPro and Primary PTCA Organization and Randomized Trial (RAPPORT) Investigators. Circulation 98:734–741PubMedCrossRefGoogle Scholar
  8. 8.
    Brodie BR, Weintraub RA, Stuckey TD et al (1991) Outcomes of direct coronary angioplasty for acute myocardial infarction in candidates and non-candidates for thrombolytic therapy. Am J Cardiol 67:7–12PubMedCrossRefGoogle Scholar
  9. 9.
    Brodie BR, Grines CL, Ivanhoe R, Knopf W, Taylor G, O’Keefe J, Weintraub A, Berdan LG, Tcheng JE, Woodlief LH, Calif RM, O’Neill WW (1994) Six-months clinical and angiographic follow-up after direct angioplasty for acute myocardial infarction. Final results from the PAR registry. Circulation 90:156–162PubMedCrossRefGoogle Scholar
  10. 10.
    Colombo A, Briguori C (1999) Primary stenting and glycoprotein IIb/ííía inhibitors in acute myocardial infarction. Am Heart J 138:153–157CrossRefGoogle Scholar
  11. 11.
    Dangas G, Mehran R, Duvvuri S, Vidhun R, Ambrose JA, Sharma SK (1998) Directional coronary atherectomy in acute myocardial infarction. Cardiology 90:63–66PubMedCrossRefGoogle Scholar
  12. 12.
    Ellis SG, da Silva ER, Heyndrickx G, Talley JD, Cernigliaro C, Steg G, Spaulding C, Nobuyoshi M, Erbel R, Vassanelli C et al (1994) Randomized comparison of rescue angioplasty with conservative management of patients with early failure of thrombolysis for acute anterior myocardial infarction. Circulation 90:2280–2284PubMedCrossRefGoogle Scholar
  13. 13.
    Ellis SG, Silva ER, Spaulding CM, Nobuyoshi M, Weiner B, Talley JD (2000) Review of immediate angioplasty after fibrinolytic therapy for acute myocardial infarction: insights from RESCUE I, RESCUE II, and other contemporary clinical experience. Am Heart J 139:1046–1053PubMedCrossRefGoogle Scholar
  14. 14.
    Every NR, Parsons LS, Hlatky M, Martin JS, Weaver WD for the MITI-Investigators (1996) A comparison of thrombolytic therapy with primary coronary angioplasty for acute myocardial infarction. New Engl J Med 335:1253–1260PubMedCrossRefGoogle Scholar
  15. 15.
    Ferguson III, JJ (2000) 72nd scientific sessions of the american heart association. CADILLAC-Study. Acute Coronary Syndromes 2:126–127Google Scholar
  16. 16.
    Garcia-Cantu E, Spaulding C, Corcos T, Hamda KB, Roussel L, Favereau X, Guerin Y, Chalet Y, Souffrant G, Guerin F (1996) Stent implantation in acute myocardial infarction. Am J Cardiol 77:451–454PubMedCrossRefGoogle Scholar
  17. 17.
    George BS, Candela RJ, Topol EJ, Stack RS, Kereiakes DJ, Abbottsmith CW, Masek R, Pickel A, Dillon J, Harrelson L et al. (1990) Brachial approach to emergency cardiac catheterization during thrombolytic therapy for acute myocardial infarction. TAMI Study Group. Cathet Cardiovasc Diagn 20:221–226PubMedCrossRefGoogle Scholar
  18. 18.
    Grines CL, Browne KF, Marco J, Rothbaum D, Stone GW, O’Keefe J, Overlie P, Donohue B, Chelliah N, Timmis GC et al (1993) A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group. N Engl J Med 328:673–679CrossRefGoogle Scholar
  19. 19.
    Grines CL (1996) Aggressive intervention for myocardial infarction: angioplasty, stents, and intraaortic balloon pumping. Am J Cardiol 78:29–34PubMedCrossRefGoogle Scholar
  20. 20.
    Grines CL, Cox DA, Stone GW, Garcia E, Mattos LA, Giambartolomei A, Brodie BR, Madonna O, Eijgelshoven M, Lansky AJ, O’Neill WW, Morice MC (1999) Coronary angioplasty with or without stent implantation for acute myocardial infarction. Stent Primary Angioplasty in Myocardial Infarction Study Group: N Engl J Med 341:1949–1956Google Scholar
  21. 21.
    Heintzen MP, Motz W, Leschke M, Schultheiss HP, Horstkotte D, Vester EG, Wahbe L, Ries T, Putz H, Sommer P, Strauer BE (1994) PTCA in the acute state of myocardial infarct: hospital course of 785 consecutive patients. Z Kardiol 83:404–413PubMedGoogle Scholar
  22. 22.
    Heintzen MP, Heidland UE, Klimek WJ, Leschke M, Kelm M, Schwartzkopff B, Vester EG, Michel CJ, Strauer BE (2000) Intracoronary dipyridamole reduces the incidence of abrupt vessel closure following PTCA: a prospective randomised trial. Heart 83:551–556PubMedCrossRefGoogle Scholar
  23. 23.
    Hochman JS, Sleeper LA, Godfrey E, McKinlay SM, Sanborn T, Col J, LeJemtel T (1999) Should we emergently revascularize Occluded Coronaries for cardiogenic shock: an international randomized trial of emergency PTCA/CABG-trial design. The SHOCK Trial Study Group. Am Heart J 137:313–321PubMedCrossRefGoogle Scholar
  24. 24.
    Horie H, Takahashi M, Minai K, Izumi M, Takaoka A, Nozawa M, Yokohama H, Fujita T, Sakamoto T, Kito O, Okamura H, Kinoshita M (1998) Long-term beneficial effect of late reperfusion for acute anterior myocardial infarction with percutaneous transluminal coronary angioplasty. Circulation 98: 2377–2382PubMedCrossRefGoogle Scholar
  25. 25.
    Ischinger TA, Neumann P, Reifart N, Haase J, Mathey D, Silber S, Escobar A, Gaspar J, Braun P, Heib K, DiSciascio G: The X-Sizer catheter system: multicenter trial of a novel device for removal of thrombo-occlusive tissue from coronary arteries. Z Kardiol 88 (Suppl 2):104 (Abstract)Google Scholar
  26. 26.
    Kander NH, O’Neill W, Topol EJ, Gallison L, Mileski R, Ellis SG (1989) Long-term follow-up of patients treated with coronary angioplasty for acute myocardial infarction. Am Heart J 118:228–233PubMedCrossRefGoogle Scholar
  27. 27.
    Kaplan BM, Larkin T, Safian RD, O’Neill WW, Kramer B, Hoffmann M, Schreiber T, Grines CL (1996) Prospective study of extraction atherectomy in patients with acute myocardial infarction. Am J Cardiol 78:383–388PubMedCrossRefGoogle Scholar
  28. 28.
    Kastrati A, Pache J, Dirschinger J, Neumann FJ, Walter H, Schmitt C, Schömig A (2000) Primary intracoronary stenting in acute myocardial infarction: long-term clinical and angiographic follow-up and risk factor analysis. Am Heart J 139:208–216PubMedCrossRefGoogle Scholar
  29. 29.
    Lefkovits J, Ivanhoe RJ, Calif RM, Bergelson BA, Anderson KM, Stoner GL, Weisman HF, Topol EJ (1996) Effects of platelet glycoprotein IIb/IIIa receptor blockade by a chimeric monoclonal antibody (abciximab) on acute and six-month outcomes after percutaneous transluminal coronary angioplasty for acute myocardial infarction. EPIC investigators. Am J Cardiol 77:1045–1051PubMedCrossRefGoogle Scholar
  30. 30.
    Michel CJ, Heintzen MP, Leschke M, Vester EG, Strauer BE (1996) Ergebnisse der Spät-Reperfusion (> 6 h) mittels PTCA bei Patienten mit akutem Myokardinfarkt. Z Kardiol 85 (Suppl 2):139Google Scholar
  31. 31.
    Michel CJ, Heintzen MP, Strauer BE (1997) Spätreperfusion beim akuten Myokardinfarkt. Bedeutung der offenen Infarktarterie. Dtsch med Wschr 122: 415–421PubMedCrossRefGoogle Scholar
  32. 32.
    Montalescot G (1999) IIb/IIIa inhibitors in acute myocardial infarction. Blood Coagul Fibrinolysis 10 (Suppl 1):571–75Google Scholar
  33. 33.
    Nakagawa Y, Matsuo S, Kimura T, Yokoi H, Tamura T, Hamasaki N, Nosaka H, Nobuyoshi M (1999) Thrombectomy with AngioJet catheter in native coronary arteries for patients with acute or recent myocardial infarction. Am J Cardiol 83:994–999PubMedCrossRefGoogle Scholar
  34. 34.
    Neumann FJ, Walter H, Richardt G, Schmitt C, Schömig A (1996) Coronary Palmaz-Schatz stent implantation in acute myocardial infarction. Heart 75:121–126PubMedCrossRefGoogle Scholar
  35. 35.
    Neumann FJ, Blasini R, Schmitt C, Alt E, Dirschinger J, Gawaz M, Kastrati A, Schömig A (1998) Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction. Circulation 98:2695–2701PubMedCrossRefGoogle Scholar
  36. 36.
    Nunn CM, O’Neill WW, Rothbaum D, Stone GW, O’Keefe J, Overlie P, Donohue B, Grines L, Browne KF, Vlietstra RE, Catlin T, Grines CL (1999) Longterm outcome after primary angioplasty: report from the primary angioplasty in myocardial infarction (PAMI-I) trial. J Am Coll Cardiol 33:640–646PubMedCrossRefGoogle Scholar
  37. 37.
    O’Keefe JH Jr, Bailey WL, Rutherford BD, Hartzler GO (1993) Primary angioplasty for acute myocardial infarction in 1000 consecutive patients. Results in an unselected population and high-risk subgroups. Am J Cardiol 16/72:107G–115GCrossRefGoogle Scholar
  38. 38.
    O’Neill WW, Weintraub R, Grines CL, Meany TB, Brodie BR, Friedman HZ, Ramos RG, Gangadharan V, Levin RN, Choksi N et al (1992) A prospective, placebo-controlled, randomized trial of intravenous streptokinase and angioplasty versus lone angioplasty therapy of acute myocardial infarction. Circulation 86:1710–1717PubMedCrossRefGoogle Scholar
  39. 39.
    Overlie PA (1998) Stents in acute myocardial infarction. Curr Opin Cardiol 13:280–288PubMedCrossRefGoogle Scholar
  40. 40.
    Restore Investigators (1997) Effects of platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction. Circulation 96:1445–1453CrossRefGoogle Scholar
  41. 41.
    Rosenschein U, Roth A, Rassin T, Basan S, Laniado S, Miller HI (1997) Analysis of coronary ultrasound thrombolysis endpoints in acute myocardial infarction (ACUTE trial). Results of the feasibility phase. Circulation 95:1411–1416PubMedCrossRefGoogle Scholar
  42. 42.
    Ross AM, Coyne KS, Reiner JS, Greenhouse SW, Fink C, Frey A, Moreyra E, Traboulsi M, Racine N, Riba AL, Thompson MA, Rohrbeck S, Lundergan CF (1999) A randomized trial comparing primary angioplasty with a strategy of short acting thrombolysis and immediate planned rescue angioplasty in acute myocardial infarction: the PACT trial. PACT investigators. Plasminogen-activator Angioplasty Compatibility Trial. J Am Coll Cardiol 34: 1954–1962PubMedCrossRefGoogle Scholar
  43. 43.
    Schömig A, Kastrati A, Dirschinger J, Mehilli J, Schricke U, Pache J, Martinoff S, Neumann FJ, Schwaiger M (2000) Coronary stenting plus platelet glycoprotein IIb/ííía blockade compared with tissue plasminogen activator in acute myocardial infarction. New Engl J Med 343:385–391PubMedCrossRefGoogle Scholar
  44. 44.
    Spaulding C, Cador R, Benhamda K, Ali OS, Garcia Cantu E, Monsegu J, Py A, Weber S (1997) One-week and six-month angiographic controls of stent implantation after occlusive and nonocclusive dissection during primary balloon angioplasty for acute myocardial infarction. Am J Cardiol 79: 1592–1595PubMedCrossRefGoogle Scholar
  45. 45.
    Steg G, Aubry P (1996) Radial access for primary PTCA in patients with acute myocardial infarction and contraindication or impossible femoral access Cathet. Cardiovasc Diagn 39:424–426CrossRefGoogle Scholar
  46. 46.
    Stone GW, Grines CL, Browne KF, Marco J, Roth-baum D, O’Keefe J, Hartzler GO, Overlie P, Donohue B, Chelliah N et al (1995) Predictors of in hospital and 6-month outcome after acute myocardial infarction in the reperfusion era: the Primary Angioplasty in Myocardial Infarction (PAMI) trail. J Am Coll Cardiol 25:370–377PubMedCrossRefGoogle Scholar
  47. 47.
    Stone GW, Grines CL, Browne KF, Marco J, Roth-baum D, O’Keefe JH, Hartzler GO, Overlie P, Donohue B, Chelliah N, Vlietstra R, Puchrowicz Ochocki S, O’Neill WW (1996) Outcome of different reperfusion strategies in patients with former contraindications to thrombolytic therapy: a comparison of primary angioplasty and tissue plasminogen activator. Primary Angioplasty in Myocardial Infarction (PAMI) Investigators. Cathet Cardiovasc Diagn 39:333–339PubMedCrossRefGoogle Scholar
  48. 48.
    Stone GW, Marsalese D, Brodie BR, Griffin JJ, Donohue B, Costantini C, Balestrini C, Wharton T, Esente P, Spain M, Moses J, Nobuyoshi M, Ayres M, Jones D, Mason D, Grines L, O’Neill WW, Grines CL (1997) A prospective, randomized evaluation of prophylactic intraaortic balloon counter-pulsation in high risk patients with acute myocardial infarction treated with primary angioplasty. Second Primary Angioplasty in Myocardial Infarction (PAMI-II) Trial Investigators. J Am Coll Cardiol 29:1459–1467PubMedCrossRefGoogle Scholar
  49. 49.
    Stone GW, Brodie BR, Griffin JJ, Morice MC, Costantini C, St. Goar FG, Overlie PA, Popma JJ, McDonnell J, Jones D, O’Neill WW, Grines CL (1998) Prospective, multicenter study of the safety and feasibility of primary stenting in acute myocardial infarction: in-hospital and 30-day results of the PAMI stent pilot trial. Primary Angioplasty in Myocardial Infarction Stent Pilot Trial Investigators. J Am Coll Cardiol 31:23–30PubMedCrossRefGoogle Scholar
  50. 50.
    Suryapranata H, van’t Hof AW, Hoorntje JC, de Boer MJ, Zijlstra F (1998) Randomized comparison of coronary stenting with balloon angioplasty in selected patients with acute myocardial infarction. Circulation 97:2502–2505PubMedCrossRefGoogle Scholar
  51. 51.
    Tiefenbrunn AJ, Chandra NC, French WJ, Gore JM, Rogers WJ (1998) Clinical experience with primary percutaneous transluminal coronary angioplasty compared with alteplase (recombinant tissue-type plasminogen activator) in patients with acute myocardial infarction: a report from the Second National Registry of Myocardial Infarction (NRMI-2). J Am Coll Cardiol 31:1240–1245PubMedCrossRefGoogle Scholar
  52. 52.
    Urban P, Stauffer JC, Bleed D, Khatchatrian N, Amann W, Bertel O, van den Brand M, Danchin N, Kaufmann U, Meier B, Machecourt J, Pfisterer M (1999) A randomized evaluation of early revascularization to treat shock complicating acute myocardial infarction. The (Swiss) Multicenter Trial of Angioplasty for Shock-(S)MASH. Eur Heart J 20: 1030–1038PubMedCrossRefGoogle Scholar
  53. 53.
    van’t Hof AW, Liem AL, de Boer MJ, Hoorntje JC, Suryapranata H, Zijlstra F (1999) A randomized comparison of intra-aortic balloon pumping after primary coronary angioplasty in high risk patients with acute myocardial infarction. Eur Heart J 20: 659–665CrossRefGoogle Scholar
  54. 54.
    Vogt A, Niederer W, Pfafferott C, Engel HJ, Heinrich W, Merx W, Jehle J, Neuhaus KL (1998) Direct percutaneous transluminal coronary angioplasty in acute myocardial infarction. Predictors of short-term outcome and the impact of coronary stenting. Study Group of The Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausärzte (ALKK). Eur Heart J 19:917–921PubMedCrossRefGoogle Scholar
  55. 55.
    Waldecker B, Waas W, Haberbosch W, Voss R, Heizmann H, Tillmanns H (1998) Long-term follow-up after direct percutaneous transluminal coronary angioplasty for acute myocardial infarction. J Am Coll Cardiol 32:1320–1325PubMedCrossRefGoogle Scholar
  56. 56.
    Weaver WD, Simes RJ, Betriu A et al (1997) Comparison of primary coronary angioplasty and intravenous thrombolytic therapy for acute myocardial infarction. A quantitative review. J 278:2093–2098Google Scholar
  57. 57.
    Yamauchi T, Furui S, Isshiki T, Toyoizumi H, Koh-take H, Takeshita K, Suzuki S, Harasawa A, Sasaki Y (1999) Emergent right coronary artery thrombectomy with a jet aspiration thrombectomy catheter. Cardiovasc Intervent Radiol 22:340–342PubMedCrossRefGoogle Scholar
  58. 58.
    Zahn R, Vogt A, Seidl K, Schuster S, Gülker H, Heinrich KW, Gottwik M, Neuhaus K, Senges J für die ALKK-Studiengruppe (1997) Ballondilatation bei akutem Herzinfarkt im klinischen Alltag: Ergebnisse des Registers der ALKK bei 4625 Patienten. Z Kardiol 86:712–721PubMedCrossRefGoogle Scholar
  59. 59.
    Zijlstra F, de Boer MJ, Reiffers S, Miedema K, Ottervanger JP, van’t Hof AWJ, Suryapranata H (1999) Long-term benefit of primary angioplasty as compared with thrombolytic therapy for acute myocardial infarction. N Engl J Med 341:1413–1419PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • M. P. Heintzen

There are no affiliations available

Personalised recommendations