Discussion: developmental disorders of the brain

  • E. Gouzoulis-Mayfrank
Conference paper


The three presentations of this session focus on neurodevelopmental aspects of the etiology of schizophrenia. The original neurodevelopmental hypothesis claims a static lesion acquired prenatally, which interacts with the normal brain maturation processes and accounts for the onset of the illness mostly during early adulthood [12]. However, the hypothesized lesion may result in several subtle and uncharacteristic cognitive, emotional and behavioral deviations already in infancy, i.e., several years prior to the onset of clear-cut psychotic symptoms. These childhood prodromal signs of schizophrenia were described by Professor Parnas in his excellent summary of high-risk studies.


Prepulse Inhibition Acoustic Startle Maternal Separation Bioi Psychiatry Gyrification Index 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • E. Gouzoulis-Mayfrank
    • 1
  1. 1.Department of Psychiatry and PsychotherapyUniversity of AachenGermany

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