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Discussion: developmental disorders of the brain

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Book cover Risk and Protective Factors in Schizophrenia
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Abstract

The three presentations of this session focus on neurodevelopmental aspects of the etiology of schizophrenia. The original neurodevelopmental hypothesis claims a static lesion acquired prenatally, which interacts with the normal brain maturation processes and accounts for the onset of the illness mostly during early adulthood [12]. However, the hypothesized lesion may result in several subtle and uncharacteristic cognitive, emotional and behavioral deviations already in infancy, i.e., several years prior to the onset of clear-cut psychotic symptoms. These childhood prodromal signs of schizophrenia were described by Professor Parnas in his excellent summary of high-risk studies.

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References

  1. Bakshi VP, Swerdlow NR, Braff DL, Geyer MA (1998) Reversal of isolation rearing-induced deficits in prepulse inhibition by seroquel and olanzapine. Biol Psychiatry 43: 436–445

    Article  PubMed  CAS  Google Scholar 

  2. Braff D, Grillon C, Geyer MA (1992) Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry 49: 206–215

    Article  PubMed  CAS  Google Scholar 

  3. Braun K, Lange E, Metzger M, Poeggel G (2000) Maternal separation followed by early social deprivation affects the development of monoaminergic fiber systems in the medial prefrontal cortex of Octodon degus. Neuroscience 95: 309–318

    Article  PubMed  CAS  Google Scholar 

  4. Geyer MA, Wilkinson LS, Humby T, Robbins TW (1993) Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry 34: 361–372

    Article  PubMed  CAS  Google Scholar 

  5. Helmeke C, Ovtscharoff W Jr, Poeggel G, Braun K (2001) Juvenile emotional experience alters synaptic inputs on pyramidal neurons in the anterior cingulate cortex. Cereb Cortex 11: 717–727

    Article  PubMed  CAS  Google Scholar 

  6. Krebs-Thomson K, Giracello D, Solis A, Geyer MA (2001) Post-weaning handling attenuates isolation-rearing induced disruptions of prepulse inhibition in rats. Behav Brain Res 120: 221–224

    Article  PubMed  CAS  Google Scholar 

  7. Lewis MH, Gluck JP, Beauchamp AJ, Keresztury MF, Mailman RB (1990) Long-term effects of early social isolation in Macaca mulatta: changes in dopamine receptor function following apomorphine challenge. Brain Res 513: 67–73

    Article  PubMed  CAS  Google Scholar 

  8. Maynard TM, Sikich L, Lieberman JA, LaMantia AS (2001) Neural development, cell-cell signaling, and the “two-hit” hypothesis of schizophrenia. Schizophr Bull 27: 457–476

    Article  PubMed  CAS  Google Scholar 

  9. Ovtscharoff W Jr, Braun K (2001) Maternal separation and social isolation modulate the postnatal development of synaptic composition in the infralimbic cortex of Octodon degus. Neuroscience 104: 33–40

    Article  PubMed  CAS  Google Scholar 

  10. Swerdlow NR, Geyer MA (1998) Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr Bull 24: 285–301

    Article  PubMed  CAS  Google Scholar 

  11. Varty GB, Braff DL, Geyer MA (1999) Is there a critical developmental ‘window’ for isolation rearing-induced changes in prepulse inhibition of the acoustic startle response? Behav Brain Res 100: 177–183

    Article  PubMed  CAS  Google Scholar 

  12. Weinberger DR (1986) The pathogenesis of schizophrenia: a neurodevelopmental theory. In: Nasarallah HA, Weinberger DR (eds) Handbook of Schizophrenia. Elsevier, New York, pp 397–406

    Google Scholar 

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© 2002 Springer-Verlag Berlin Heidelberg

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Gouzoulis-Mayfrank, E. (2002). Discussion: developmental disorders of the brain. In: Häfner, H. (eds) Risk and Protective Factors in Schizophrenia. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57516-7_8

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  • DOI: https://doi.org/10.1007/978-3-642-57516-7_8

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63282-2

  • Online ISBN: 978-3-642-57516-7

  • eBook Packages: Springer Book Archive

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