Skip to main content
SpringerLink
Log in
Book cover

Haare pp 27–40Cite as

Haarbiologische Grundlagen und pathobiologische Erwägungen

  • Chapter

  • 325 Accesses

Zusammenfassung

Während die biologischen Funktionen des Haars (Tab. 3.1) im Zuge seiner entwicklungsgeschichtlich bedingten Reduktion weitgehend in den Hintergrund getreten sind, dominiert beim Menschen die soziale Kommunikationsfunktion vornehmlich der Kopf- und Sexualbehaarung. Einzig den Augenbrauen, Wimpern und Vibrissae im Naseneingang kommt weiterhin eine wichtige Schutzfunktion zu. Fehlen z. B. Augenbrauen und Wimpern (im Rahmen einer Alopecia areata), können Schweiß von der Stirn und Staub leichter ins Auge dringen und zu Reizungen der Konjunktiva führen. Aber auch die Kopfbehaarung bietet einen Schutz vor UV-Strahlen. Nicht selten entstehen aktinische Keratosen (Präkanzerosen) und Karzinome auf dem Boden einer chronisch UV-geschädigten, meist androgenetisch bedingten Alopezie.

Die ganze Natur ist eigentlich nichts anderes als ein Zusammenhang von Erscheinungen nach Regeln.

Immanuel Kant

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   149.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Hardy MH (1992) The secret life of the hair follicle. Trends Genet 8:55–61

    PubMed  CAS  Google Scholar 

  • Paus R, Müller-Röver S (1998) Biologie des Haarfolli-kels. In: Plewig G, Wolff H (Hrsg) Fortschritte der praktischen Dermatologie und Venerologie. Springer, Berlin, S 66–79

    Google Scholar 

  • Paus R, Cotsarelis G (1999) The biology of hair follicles. N Engl J Med 341:491–497

    Article  PubMed  CAS  Google Scholar 

■ Literatur

  • Müller-Röver S, Paus R (1998) Topobiology of the hair follicle: adhesion molecules as morphoregulatory signals during hair follicle morphogenesis. In: Chuong C-M (Hrsg) Molecular Basis of Epithelial Appendage Morphogenesis. Landes, Austin/Tex, pp 283–314

    Google Scholar 

  • Peus D, Pittelkow MR (1996) Growth factors in hair organ development and the hair growth cycle. Dermatol Clin 14:559–572

    Article  PubMed  CAS  Google Scholar 

  • Philpott M, Paus R (1998) Principles of hair follicle morphogenesis. In: Chuong C-M (Hrsg) Molecular Basis of Epithelial Appendage Morphogenesis. Landes, Austin/Tex, pp 75–110

    Google Scholar 

  • Reynolds A, Lawrence C, Cserhalmi-Friedman PB et al. (1999) Trans-gender induction of hair follicles. Nature 402:33–34

    Article  PubMed  CAS  Google Scholar 

  • Stenn KS, Combates NJ, Eilertsen KH et al. (1996) Hair follicle growth controls. Dermatol Clin 14: 543–558

    Article  PubMed  CAS  Google Scholar 

  • Sundberg JP, King LE Jr (1996) Mouse models for the study of human hair loss. Dermatol Clin 14:619–632

    PubMed  CAS  Google Scholar 

■ Literatur

  • Lavker RM, Miller S, Wilson C et al. (1993) Hair follicle stem cells: their location, role in hair cycle, and involvement in skin tumor formation. J Invest Dermatol 101:16S–26S

    Article  PubMed  CAS  Google Scholar 

  • Lavker RM, Sun TT (1995) Hair follicle stem cells: present concepts. J Invest Dermatol 104:38S–39S

    Article  PubMed  CAS  Google Scholar 

  • Panconesi E, Hautmann G (1996) Psychophysiology of stress in dermatology. The psychobiologic pattern of psychosomatics. Dermatol Clin 14:399–421

    Article  PubMed  CAS  Google Scholar 

  • Paus R, Handjiski B, Czarnetzki BM (1994) Biologie des Haarfollikels. Hautarzt 45:808–825 (1994)

    Article  PubMed  CAS  Google Scholar 

  • Sperling LC (1991) Hair anatomy for the clinician. J Am Acad Dermatol 25:1–17

    Article  PubMed  CAS  Google Scholar 

■ Literatur

  • Cotsarelis G, Sun TT, Lavker RM (1990) Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle and skin carcinogenesis. Cell 61:1329–1337

    Article  PubMed  CAS  Google Scholar 

  • Guarrera M, Rebora A (1996) Anagen hairs may fail to replace telogen hairs in early androgenetic female alopecia. Dermatology 192:28–31

    Article  PubMed  CAS  Google Scholar 

  • Messenger AG (1993) The control of hair growth: an overview. J Invest Dermatol 101:4S–9S

    Article  PubMed  CAS  Google Scholar 

  • Panteleyev A, Jahoda C, Christiano A (2001) The hypothesis of hair follicle predetermination (abstract 219). J Invest Dermatol 117:426

    Google Scholar 

  • Paus R, Czarnetki BM (1992) Neue Perspektiven in der Haarforschung: auf der Suche nach der „biologischen Uhr“ des Haarzyklus. Hautarzt 43:264–271

    PubMed  CAS  Google Scholar 

  • Paus R, Müller-Röver S, Botchkarev VA (1999) Chronobiology of the hair follicle: hunting the “hair cycle clock”. Invest Dermatol Symp Proc 4:338–345

    Article  CAS  Google Scholar 

  • Pierard-Franchimont C, Pierard GE (2001) Teloptosis, a turning point in hair shedding biorhythms. Dermatology 203:115–117

    Article  PubMed  CAS  Google Scholar 

  • Rebora A, Guarrera M (2002) Kenogen. A new phase of the hair cycle? Dermatology 205:108–110

    Article  PubMed  Google Scholar 

  • Sawaya ME (2001) Regulation of the human hair cycle. Curr Probi Dermatol 13:206–210

    Article  Google Scholar 

  • Stenn KS, Combates NJ, Eilertsen KH et al. (1996) Hair follicle growth controls. Dermatol Clin 14: 543–558

    Article  PubMed  CAS  Google Scholar 

  • Stenn KS, Eilertsen K (1996) Molecular basis of hair growth control. J Invest Dermatol 107:671–675

    Article  Google Scholar 

  • Stenn K, Parimoo S, Prouty S (1998) Growth of the hair follicle: a cycling and regenerating biological system. In: Chuong C-M (Hrsg) Molecular Basis of Epithelial Appendage Morphogenesis. Landes, Austin/Tex

    Google Scholar 

  • Stenn KS, Nixon AJ, Jahoda CAB, McKay IA, Paus R (1999) What controls hair follicle cycling? Exp Dermatol 8:229–236

    Article  PubMed  CAS  Google Scholar 

  • Sun T-T, Cotsarelis G, Lavker RM (1991) Hair follicle stem cells: the bulge-activation hypothesis. J Invest Dermatol 96:775–785

    Google Scholar 

■ Literatur

  • Christoph T, Müller-Röver S, Audring H et al. (2000) The human hair follicle immune system: cellular composition and immune privilege. Br J Dermatol 142:862–873

    Article  PubMed  CAS  Google Scholar 

  • Eichmüller S, van der Veen C, Moll I et al. (1998) Clusters of perifollicular macrophages in normal murine skin: physiological degeneration of selected hair follicles by programmed organ deletion. J Histochem Cytochem 46:361–370

    Article  PubMed  Google Scholar 

  • Hofmann R, Happle R (1996) Topical immunotherapy in alopecia areata: what, how, and why? Dermatol Clin 14:739–744

    Article  Google Scholar 

  • Jaworsky C, Gilliam AC (1999) Immunopathology of the human hair follicle. Dermatol Clin 17:561–568

    Article  PubMed  CAS  Google Scholar 

  • Kossard S (1999) Diffuse alopecia with stem cell folliculitis. Chronic diffuse alopecia areata or a distinct entity. Am J Dermatopath 21:46–50

    Article  PubMed  CAS  Google Scholar 

  • Murphy GF, Lavker RM, Whitaker D, Korngold R (1991) Cytotoxic folliculitis in GvHD: evidence of follicular stem cell injury and recovery. J Cutan Pathol 18:309–314

    Article  PubMed  CAS  Google Scholar 

  • Paus R (1997) Immunology of the hair follicle. In: Bos JD (Hrsg) Skin Immune System. Cutaneous Immunology and Clinical Immunodermatology. CRC Press, New York, pp 377–398

    Google Scholar 

  • Paus R, Christoph T, Müller-Röver S (1999) Immunology of the hair follicle: a short journey into terra incognita. Invest Dermatol Symp Proc 4:226–234

    Article  CAS  Google Scholar 

  • Philpott MP, Sander DA, Bowen J, Kealey T (1996) Effects of interleukins, colony stimulating factor and tumour necrosis factor on human hair follicle growth in vitro: a possible role for interleukin-1 and tumour necrosis factor-α in alopecia areata. Br J Dermatol 135:942–948

    Article  PubMed  CAS  Google Scholar 

  • Pierard-Franchimont C, Pierard GE (1986) Massive lymphocyte-mediated apoptosis during early stage of pseudopelade. Dermatologica 192:254–257

    Article  Google Scholar 

  • Trüeb RM (2000) Autoimmundermatosen: Neue therapeutische Strategien. Praxis (Schweiz Rundsch Med) 89:1460–1467

    Google Scholar 

  • Zinkernagel MS, Trüeb RM (2000) Fibrosing alopecia in a pattern distribution. Patterned lichen planopilaris or androgenetic alopecia with a lichenoid tissue reaction pattern? Arch Dermatol 136:205–211

    Article  PubMed  CAS  Google Scholar 

■ Literatur

  • Headington JT (1993) Telogen effluvium. New concepts and review. Arch Dermatol 129:356–363

    Article  PubMed  CAS  Google Scholar 

  • Kaufman KD (1996) Androgen metabolism as it affects hair growth in androgenetic alopecia. Dermatol Clin 14:697–711

    Article  PubMed  CAS  Google Scholar 

  • Li L, Hoffman RM (1995) The feasibility of targeted selective gene therapy of the hair follicle. Nature Med 1:705–706

    Article  PubMed  Google Scholar 

  • Paus R, Rosenbach T, Haas N, Czarnetski BM (1993) Patterns of cell death: the significance of apoptosis for dermatology. Exp Dermatol 2:3–11

    Article  PubMed  CAS  Google Scholar 

  • Paus R, Menrad A, Czarnetski B (1995) Nekrobiologie der Haut: Apoptose. Hautarzt 46:285–303

    PubMed  CAS  Google Scholar 

  • Paus R (1996) Control of the hair cycle and hair diseases as cycling disorders. Curr Opin Dermatol 3:248–258

    Google Scholar 

  • Paus R, Christoph T, Müller-Röver S (1999) Immunology of the hair follicle: a short journey into terra incognita. Invest Dermatol Symp Proc 4:226–234

    Article  CAS  Google Scholar 

  • Paus R (2001) Alopezien und Hypertrichosen — Störungen des Haarzyklus? Symposium, München, Neues zur Therapie von Alopezien und Hypertrichosen

    Google Scholar 

  • Stenn KS (1999) Hair follicle biology, the sebaceous gland, and scarring alopecia. Arch Dermatol 135:973–974

    Article  PubMed  CAS  Google Scholar 

  • Sundberg JP, King LE Jr (1996) Mouse models for the study of human hair loss. Dermatol Clin 14:619–632

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dermatologische Klinik, UniversitätsSpital Zürich, Gloriastrasse 31, CH-8091, Zürich, Switzerland

    Ralph M. Trüeb

Authors
  1. Ralph M. Trüeb
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Trüeb, R.M. (2003). Haarbiologische Grundlagen und pathobiologische Erwägungen. In: Haare. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57448-1_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57448-1_3

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63269-3

  • Online ISBN: 978-3-642-57448-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation