The term perfusion normally refers to the delivery of blood at the capillary level, where the metabolic exchange of nutrients and oxygen takes place. Perfusion-weighted MR imaging (PWI) allows the measurement of capillary perfusion with the dynamic susceptibility contrast-enhanced (DSC) technique. A paramagnetic contrast agent is injected as an intravenous bolus and the signal change is tracked by ultrafast MR sequences in the area of interest [283, 284, 358]. Analogous to concentration time curves obtained with, e.g., Swan Ganz (pulmonary artery) catheters after injection of ice water (temperature probe) or indocyanine green (infrared probe), cerebrovascular (as opposed to cardiac output or vascular resistance measurements) hemodynamic parameters can be derived from the MR-de-rived contrast-bolus over time curve.
KeywordsContrast Agent Cerebral Blood Flow Cerebral Blood Volume Infarct Core Contrast Bolus
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