Abstract
When naive T cells home to lymph nodes, they first roll along high endothelial venules using CD62L, allowing the chemokine receptor CCR7 to engage its ligand, SLC, displayed by endothelial cells. The CCR7-SLC interaction activates integrins that promote firm adhesion and transmigration of the T cells into the lymph node (Butcher and Picker, 1996; Cyster, 1999).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ahmed R, Gray D (1996) Immunological memory and protective immunity: understanding their relation. Science 272, 54–60
Altman JD, Moss PAH, Goulder PJR, Barouch DH, McHeyzer-Williams MG, Bell JI, McMichael AJ, Davis MM (1996) Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94–96
Austrup F, Vestweber D, Borges E, Lohning M, Brauer R, Herz U, Renz H, Hallmann R, Scheffold A, Radbruch A, Hamann A (1997) P- and E-selectin mediate recruitment of Thelper-1 but not T-helper-2 cells into inflamed tissues. Nature 385, 81–83
Butcher EC, Picker LJ (1996) Lymphocyte homing and homeostasis. Science 272, 60–66
Cyster JG (1999) Chemokines and cell migration in secondary lymphoid organs. Science 286, 2098–2102
Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof-Garde SR, Klein MR, van Lier RA (1997) Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 186, 1407–1418
Lanzavecchia A, Sallusto F (2000) From synapses to immunological memory: the role of sustained T cell stimulation. Curr Opin Immunol 12:92–98
Mackay CR (1993) Homing of naive, memory and effector lymphocytes. Curr Opin Immunol 5, 423–427
Mackay CR, Marston WL, Dudler L (1990) Naive and memory T cells show distinct pathways of lymphocyte recirculation. J Exp Med 171, 801–817
Michie CA, McLean A, Alcock C, Beverley PC (1992) Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360, 264–5
Sallusto F, Lanzavecchia A, Mackay CR (1998) Chemokines and chemokine receptors in T-cell priming and Thl/Th2-mediated responses. Immunol Today 19, 568–574
Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708–712
Sprent J, Tough DF, Sun S (1997) Factors controlling the turnover of T memory cells. Immunol Rev 156, 79–85
Tanchot C, Rocha B (1998) The organization of mature T-cell pools. Immunol Today 19, 575–579
Unutmaz D, Pileri P, Abrignani S (1994) Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 180, 1159–1164
Zinkernagel RM, Bachmann MF, Kundig TM, Oehen S, Pirchet H, Hengartner H (1996) On immunological memory. Annu Rev Immunol 14, 333–367
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sallusto, F., Langenkamp, A., Geginat, J., Lanzavecchia, A. (2000). Functional Subsets of Memory T Cells Identified by CCR7 Expression. In: Melchers, F. (eds) Lymphoid Organogenesis. Current Topics in Microbiology and Immunology, vol 251. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57276-0_21
Download citation
DOI: https://doi.org/10.1007/978-3-642-57276-0_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-63186-3
Online ISBN: 978-3-642-57276-0
eBook Packages: Springer Book Archive