Abstract
Endothelial and hemopoietic cells of the avian embryonic yolk sac arise from hemangioblastic aggregates, which are clusters of mesodermal cells. These aggregates are present at the border of the embryonic and extraembryonic area from the beginning of the second day of the incubation period (around the 1-somite stage). They subsequently mature to blood islands, the external cells of which flatten and differentiate into endothelial cells (EC), while the internal cells of the cluster form hemopoietic cells (HC). Evidence for blood island formation was initially obtained by observations of living chick blastoderms (Sabin 1920; Murray 1932) (Fig. 1). Based on the simultaneous emergence of EC and HC in the blood islands, it was proposed that the two cell types originate from a common precursor, termed hemangioblast. Recent evidence, which will be summarized here, suggests that hemangioblastic precursors can be identified based on their expression of vascular endothelial growth factor receptor 2 (VEGFR2).
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Eichmann, A., Corbel, C., Pardanaud, L., Bréant, C., Moyon, D., Yuan, L. (2000). Hemangioblastic Precursors in the Avian Embryo. In: Melchers, F. (eds) Lymphoid Organogenesis. Current Topics in Microbiology and Immunology, vol 251. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57276-0_11
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DOI: https://doi.org/10.1007/978-3-642-57276-0_11
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