Abstract
Chlamydia pneumoniae is transmitted from man to man and no animal species has been implicated in its circulation [1]. However, chlamydial strains closely related to C. pneumoniae have been found in animals [2, 3], and the disease can be easily transmitted into experimental animals. Thus far, three animal models for C. pneumoniae infection have been evaluated. C. pneumoniae is capable to infect mice, monkeys and rabbits by different challenge routes, e.g., by intranasal, intravenous and subcutaneous inoculations.
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References
Kuo CC, Jackson LA, Campbell LA, Grayston JT. (1995) Chlamydia pneumoniae (TWAR). Clin Microbiol Rev 8: 451–461
Girjes AA, Carrick FN, Lavin MF. (1994) Remarkable sequence relatedness in the DNA encoding the major outer membrane protein of Chlamydia psittaci (koala type I) and Chlamydia pneumoniae. Gene 138: 139–142
Storey C, Lusher M, Yates P, Richmond S. (1993) Evidence for Chlamydia pneumoniae of non-human origin. J Gen Microbiol 139: 2621–2626
Bell TA, Kuo CC, Wang SP, Grayston JT. (1989) Experimental infection of baboons (Papio cynocephalus anubis) with Chlamydia pneumoniae strain TWAR. J Infect 19: 47–49
Holland SM, Taylor H, Gaydos CA, Kappus EW, Quinn TC. (1990) Experimental infection with Chlamydia pneumoniae in nonhuman primates. Infect Immun 58: 593–597
Kishimoto T. (1990) Studies on Chlamydia pneumoniae, strain TWAR infection. I. Experimental infection of C. pneumoniae in mice and serum antibodies against TWAR by MFA. J Jap Assoc Infect Dis 64: 124–131
Kaukoranta-Tolvanen SS, Laurila AL, Saikku P, Leinonen M, Liesirova L, Laitinen K. (1993) Experimental infection of Chlamydia pneumoniae in mice. Microb Pathog 15: 293–302
Yang ZP, Kuo CC, Grayston JT. (1993) A mouse model of Chlamydia pneumoniae strain TWAR pneumonitis. Infect Immun 61: 2037–2040
Kaukoranta-Tolvanen SS, Laurila A, Saikku P, Leinonen M, Laitinen K. (1995) Experimental Chlamydia pneumoniae infection in mice: Effect of reinfection and passive immunization. Microb Pathog 18: 279–288
Yang ZP, Cummings PK, Patton DL, Kuo CC. (1994) Ultrastructural lung pathology of experimental Chlamydia pneumoniae pneumonitis in mice. J Infect Dis 170: 464–467
Yang YS, Kuo CC, Chen WJ. (1987) Reactivation of Chlamydia trachomatis lung infection in mice by cortisone. Infect Immun 39: 655–658
Malinverni R, Kuo CC, Campbell LA, Grayston JT. (1995) Reactivation of Chlamydia pneumoniae lung infection in mice by cortisone. J Infect Dis 172: 593–594
Laitinen K, Laurila A, Leinonen M, Saikku P. (1996) Reactivation of Chlamydia pneumoniae infection in mice by cortisone treatment. Infect Immun 64: 1488–1490
Yang ZP, Kuo CC, Grayston JT. (1995) Systemic dissemination of Chlamydia pneumoniae following intranasal inoculation of mice. J Infect Dis 171: 736–738
Moazed TC, Kuo CC, Patton DL, Grayston JT, Campbell LA. (1996) Experimental rabbit models of Chlamydia pneumoniae infection. Am J Pathol 148: 667–676
Moazed TC, Kuo CC, Grayston JT, Campbell LA. (1997) Murine models of Chlamydia pneumoniae infection and atherosclerosis. J Infect Dis 175: 883–890
Hu H, Pierce GN, Zhong G. (1999) The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae. J Clin Invest 103: 747–753
Bachmaier K, Neu N, de la Maza LM, Pal S, Hassel A, Penninger JM. (1999) Chlamydia infections and heart disease linked through antigenic mimicry. Science 283: 1335–1339
Fong IW, Chiu B, Viira E, Fong MW, Jang D, Mahony J. (1997) Rabbit model for Chlamydia pneumoniae infection. J Clin Microbiol 35: 48–52
Laitinen K, Laurila A, Pyhälä L, Leinonen M, Saikku P. (1997) Chlamydia pneumoniae infection induces inflammatory changes in the aortas of rabbits. Infect Immun 65: 4832–4835
Muhlestein JB, Anderson JL, Rammond ER, Zhao L, Trehan S, Schwobe BS, Carlquist JF. (1998) Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. Circulation 97: 633–636
Malinverni R, Kuo CC, Campbell LA, Lee A, Grayston JT. (1995) Effects of two antibiotic regimens on course and persistence of experimental Chlamydia pneumoniae (TWAR) pneumonitis. Antimicrobial Agents Chemother 39: 45–49
Soejima R, Niki Y, Kishimoto T, Miyashita N, Kubota Y, Nakata K. (1995) In vitro and in vivo activities of new fluoroquinolones against Chlamydia pneumoniae. Can J Infect Dis 6 (Suppl C): 354C
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Leinonen, M., Saikku, P. (2000). Animal models for Chlamydia pneumoniae infection. In: L’age-Stehr, J. (eds) Chlamydia pneumoniae and Chronic Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57195-4_4
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DOI: https://doi.org/10.1007/978-3-642-57195-4_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-41136-9
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