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Atherosclerosis: Why the search for a causative infectious agent is not warranted

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Chlamydia pneumoniae and Chronic Diseases
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Abstract

The author contends that there is sufficient evidence to exclude a major causative role for infectious agents in the pathogenesis of atherosclerosis. The arguments are summarized as follows.

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References

  1. Bhakdi S. (1998) Complement and atherogenesis: the unknown connection. Ann Med 30: 503–507

    Article  PubMed  CAS  Google Scholar 

  2. Bhakdi S, Dorweiler B, Kirchmann R, Torzewski J, Weise E, Tranum-Jensen J, Walev I, Wieland E. (1995) On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moiety. J Exp Med 182: 1959–1971

    Article  PubMed  CAS  Google Scholar 

  3. Bhakdi S, Torzewski M, Klouche M, Hemmes M. (1999) Complement and atherogenesis: binding of CRP to degraded, non-oxidized LDL enhances complement activation. Arterioscler Thromb Vasc Biol 19: 2348–2354

    Article  PubMed  CAS  Google Scholar 

  4. Klouche M, May AE, Hemmes M, Messner M, Kanse SM, Preissner K, Bhakdi S. (1999) Enzymatically modified, non-oxidized LDL induces selective adhesion and transmigration of monocytes and T-lymphocytes through human endothelial cell monolayers. Arterioscler Thromb Vasc Biol 19: 784–793

    Article  PubMed  CAS  Google Scholar 

  5. Klouche M, Gottschling S, Gerl V, Hell W, Husmann M, Dorweiler B, Messner M, Bhakdi S. (1998) Atherogenic properties of enzymatically degraded LDL: selective induction of MCP-1 and cytotoxic effects on human macrophages. Arterioscler Thromb Vasc Biol 18: 1376–1385

    Article  PubMed  CAS  Google Scholar 

  6. Seifert PS, Hugo F, Tranum-Jensen J, Zahringer U, Muhly M, Bhakdi S. (1990) Isolation and characterization of a complement-activating lipid extracted from human atherosclerotic lesions. J Exp Med 172: 547–557

    Article  PubMed  CAS  Google Scholar 

  7. Torzewski M, Klouche M, Hock J, Messner M, Dorweiler B, Torzewski J, Gabbert HE, Bhakdi S. (1998) Immunohistochemical demonstration of enzymatically modified human LDL and its colocalization with the terminal complement complex in the early atherosclerotic lesion. Arterioscler Thromb Vasc Biol 18: 369–378

    Article  PubMed  CAS  Google Scholar 

  8. Torzewski J, Torzewski M, Bowyer DE, Frohlich M, Koenig W, Waltenberger J, Fitzsimmons C, Hombach V. (1998) C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries. Arterioscler Thromb Vasc Biol 18: 1386–1392

    Article  PubMed  CAS  Google Scholar 

  9. Seifert PS, Hugo F, Hansson GK, Bhakdi S. (1989) Prelesional complement activation in experimental atherosclerosis. Terminal C5b-9 complement deposition coincides with cholesterol accumulation in the aortic intima of hypercholesterolemic rabbits. Lab Invest 60: 747–754

    PubMed  CAS  Google Scholar 

  10. Schmiedt W, Kinscherf R, Deigner HP, Kamencic H, Nauen O, Kilo J, Oelert H, Metz J, Bhakdi S. (1998) Complement C6-deficiency protects against diet-induced atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol 18: 1790–1795

    Article  PubMed  CAS  Google Scholar 

  11. Hebert PR, Gaziano JM, Chan KS, Hennekens H. (1997) Cholesterol lowering with statin drugs, risk of stroke, and total mortality. J Am Med Ass 278: 313–320

    Article  CAS  Google Scholar 

  12. de Groot E, Jukema JW, van Swijjndregt ADM, Zwinderman AH, Ackerstaff RGA, van der Steen AFW, Born N, Lie KI, Bruschke VG. (1998) B-mode ultrasound assessment of pravastatin treatment effect on carotid and femoral artery walls and its correlations with coronary arteriographic findings: a report of the regression growth evaluation statin study (REGRESS). J Am Coll Cardiol 31: 1561–1567

    Article  PubMed  Google Scholar 

  13. Maass M, Gieffers J, Krause E, Engel PM, Bartels C, Solbach W. (1998) Poor correlation between microimmunofluorescence serology and polymerase chain reaction for detection of vascular Chlamydia pneumoniae infection in coronary artery disease patients. Med Microbiol Immunol 187: 1103–1106

    Article  Google Scholar 

  14. Bachmaier K, Neu N, de la Maza LM, Pal S, Hessel A, Penninger JM. (1999) Chlamydia infections and heart disease linked through antigenic mimicry. Science 283: 1335–1339

    Article  PubMed  CAS  Google Scholar 

  15. Hu H, Pierce GN, Zongh G. (1999) The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniae. J Clin Invest 103: 747–753

    Article  PubMed  CAS  Google Scholar 

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© 2000 Springer-Verlag Berlin Heidelberg

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Bhakdi, S. (2000). Atherosclerosis: Why the search for a causative infectious agent is not warranted. In: L’age-Stehr, J. (eds) Chlamydia pneumoniae and Chronic Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57195-4_17

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  • DOI: https://doi.org/10.1007/978-3-642-57195-4_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41136-9

  • Online ISBN: 978-3-642-57195-4

  • eBook Packages: Springer Book Archive

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