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Chlamydia pneumoniae in atherosclerosis

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Chlamydia pneumoniae and Chronic Diseases

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Abstract

The previously proposed risk factors cannot explain the prevalence of coronary heart disease (CHD) and the most effective drugs against CHD, statins, do not prevent 70–80 % of the cases. New means to cure the leading cause of death all over the world are needed. The inflammatory nature of atherosclerosis underlying coronary heart disease is well established, and oxidized or enzymatically modified LDL have been the prime candidates as causes of this inflammation [1,2]. Recently, however, common viruses of the herpes virus group, dental infections, H. pylori infections and, first of all, infections caused by a common, obligatory intracellular, respiratory bacterial pathogen, C. pneumoniae, have been suggested to associate with CHD. Over the last years, several reviews [3–13] and numerous editorials on the subject appeared and seroepidemiological and histopathological findings were supported with results of animal experiments and preliminary intervention trials. In this review, principally the most recent findings are discussed; for earlier references, the reader is referred to the review by Mattila and others [9].

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Saikku, P. (2000). Chlamydia pneumoniae in atherosclerosis. In: L’age-Stehr, J. (eds) Chlamydia pneumoniae and Chronic Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57195-4_12

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