Advertisement

Present and Future of Sentinel Node Lymphadenectomy in Breast Cancer

  • U. Veronesi
  • S. Zurrida
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 157)

Abstract

Up to about 1960, it was generally thought that breast cancer was mainly a local-regional disease. This concept, inherited from Halsted, led to increasingly aggressive treatments of the primary lesion and the regional lymph nodes. Total mastectomy, which in the form developed by Halsted was already an extensive operation, became enlarged to include extensive removal of skin and use of skin transplants, sacrifice of important vessels and nerves such as the thoracodorsals, and meticulous dissection of the regional nodes, sometimes including those of the internal mammary chain via thoracotomy. Radiotherapy was given to the axillary, supraclavicular and retrosternal lymph node areas, as well as to the mastectomy scar.

Keywords

Breast Cancer Sentinel Node Axillary Lymph Node Axillary Dissection Axillary Lymph Node Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Veronesi U, Saccozzi R, Del Vecchio M, et al. Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 1981; 305: 6–11PubMedCrossRefGoogle Scholar
  2. 2.
    Veronesi U, Cascinelli N, Bufalino R, et al. Risk of internal mammary lymph node metastases and its relevance on prognosis of breast cancer patients. Ann Surg 1983; 198: 681–684PubMedCrossRefGoogle Scholar
  3. 3.
    Veronesi U, Marubini E, Mariani L, et al. The dissection mammary nodes does not improve the survival of breast cancer patients. 30 years of a randomized trial. Eur J Cancer, 1999; 35:1320–1325PubMedCrossRefGoogle Scholar
  4. 4.
    Cabanas RM. An approach for the treatment of penile carcinoma. Cancer 1977; 39:456–466PubMedCrossRefGoogle Scholar
  5. 5.
    Gallico E, Giacomelli V, Pricolo V. La colorazione vitale dei linfatici nella chirurgi a dei tumori. Chirurgia 1954; 9(3):1–8Google Scholar
  6. 6.
    Cope O. Surgery of the thyroid. In: The thyroid and its diseases. By JH Means, LJ De Groot, JB Stanbury. McGraw-Hill, New York 1963:561–598Google Scholar
  7. 7.
    Morton D, Wen D, Wong JH, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 1992; 127:392–399PubMedCrossRefGoogle Scholar
  8. 8.
    Giuliano AE. Sentinel lymphadenectomy in primary breast carcinoma: an alternative to routine axillary dissection. J Surg Oncol 1996; 62(2):75–77PubMedCrossRefGoogle Scholar
  9. 9.
    Veronesi U, Paganelli G, Viale G, et al. Sentinel lymph node biopsy and axillary dissection in breast cancer: results in a large series. J Natl. Cancer Inst 1999; 91(4):368–373PubMedCrossRefGoogle Scholar
  10. 10.
    Borgstein PJ, Pijpers, Comans EF, et al. Sentinel lymph node biopsy in breast cancer: guidelines and pitfalls of lymphoscintigraphy and gamma probe detection. J Am Coll Surg 1998; 186:275–283PubMedCrossRefGoogle Scholar
  11. 11.
    Krag D, Weaver D, Ashikana T, et al. The sentinel node in breast cancer-a multicenter validation study. New Engl J Med 1998; 339(14):941–946PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • U. Veronesi
    • 1
  • S. Zurrida
    • 1
  1. 1.Istituto Europeo di OncologiaMilanItaly

Personalised recommendations