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Keratolytics

  • Chapter
Dermatopharmacology of Topical Preparations

Abstract

Stratum corneum is a tough and almost impermeable outer layer of the body, consisting of about 20 stacked layers of corneocytes. The corneocytes are the end product of the keratinocytes, which are continuously produced in the basal layer of the epidermis. The loss of single corneocytes at the skin surface (desquamation) takes place in a controlled manner, in which proteases are involved [1]. At equilibrium, the rate of epidermal cell production corresponds to the loss of desquamative cells, although the details of the link between these two parameters are obscure.

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Authors
  1. Marie Lodén
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Editors and Affiliations

  1. Abteilung Biopharmazie Spirig AG, Pharmazeutische Präparate, 4622, Egerkingen, Switzerland

    Bernard Gabard

  2. Institut für Spital-Pharmazie, Universitätskliniken/Kantonspital Basel, Spitalstraße 26, 4031, Basel, Switzerland

    Christian Surber

  3. Klinik für Hautkrankheiten, Klinikum der Friedrich Schiller-Universität Jena, Erfurter Straße 35, 07740, Jena, Germany

    Peter Elsner

  4. Laboratoires Spirig SA, 109, Boulevard d’Haussonville, 5400, Nancy, France

    Pierre Treffel

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Lodén, M. (2000). Keratolytics. In: Gabard, B., Surber, C., Elsner, P., Treffel, P. (eds) Dermatopharmacology of Topical Preparations. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57145-9_17

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  • DOI: https://doi.org/10.1007/978-3-642-57145-9_17

  • Publisher Name: Springer, Berlin, Heidelberg

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