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Dermatopharmacology of Topical Preparations pp 179–190Cite as

Antiphlogistics (Dermocorticoids and topical immunomodulators)

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Abstract

Given that many skin disorders have an immunologic basis or involve inflammatory reactions, compounds affecting the afferent or the effector limbs of immune responses play a central role in dermatologic therapy. Topical glu-cocorticosteroids (GCs) represent the mainstay of anti-inflammatory and im-munosuppressive treatment of inflammatory skin diseases. However, despite their broad and common usage, some mechanisms by which GCs exert their functions still remain obscure. It is thought that binding of a GC to a cyto-plasmic glucocorticosteroid receptor (GCR) [65] leads to dissociation of a complex composed of a GCR and two heat-shock proteins [51]. This dissociation is followed by migration of the GCR-GC complex into the nucleus and binding to specific DNA sites called glucocorticoid response elements (GC-REs). A number of genes have been identified that are regulated by GC-REs, including lipocortin-1, an inhibitor of phospholipase A2 [22]. In addition, there is evidence that GCs can directly inhibit phospholipase A2 [51]. Both direct and indirect effects on phospholipase A2 synergistically decrease mediators of inflammation such as thromboxanes, prostaglandins, and leuko-trienes, thus inhibiting leukocyte attraction to sites of inflammation [27, 28].

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  1. Michael P. Schön
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  2. Bernhard Homey
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  3. Thomas Ruzicka
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Editors and Affiliations

  1. Abteilung Biopharmazie Spirig AG, Pharmazeutische Präparate, 4622, Egerkingen, Switzerland

    Bernard Gabard

  2. Institut für Spital-Pharmazie, Universitätskliniken/Kantonspital Basel, Spitalstraße 26, 4031, Basel, Switzerland

    Christian Surber

  3. Klinik für Hautkrankheiten, Klinikum der Friedrich Schiller-Universität Jena, Erfurter Straße 35, 07740, Jena, Germany

    Peter Elsner

  4. Laboratoires Spirig SA, 109, Boulevard d’Haussonville, 5400, Nancy, France

    Pierre Treffel

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Schön, M.P., Homey, B., Ruzicka, T. (2000). Antiphlogistics (Dermocorticoids and topical immunomodulators). In: Gabard, B., Surber, C., Elsner, P., Treffel, P. (eds) Dermatopharmacology of Topical Preparations. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57145-9_12

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